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Head and neck carcinoma

MedGen UID:
854345
•Concept ID:
C3887461
•
Neoplastic Process
Synonyms: carcinoma of craniocervical region; Carcinoma of Head and Neck; carcinoma of head and neck; carcinoma of neck; Carcinoma of the Head and Neck; carcinoma of the head and neck; craniocervical region carcinoma; head and neck cancer; Head and Neck Carcinoma; head and neck carcinoma; neck carcinoma
 
Monarch Initiative: MONDO:0002038

Definition

A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHead and neck carcinoma

Professional guidelines

PubMed

Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
Oligometastases in head and neck carcinoma and their impact on management.
Mat Lazim N, Elliott M, Wykes J, Clark J
ANZ J Surg 2021 Dec;91(12):2617-2623. Epub 2021 Feb 26 doi: 10.1111/ans.16622. PMID: 33634950
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

Head and neck radiotherapy-induced carotid toxicity: Pathophysiological concepts and clinical syndromes.
Leboucher A, Sotton S, Gambin Flandrin I, Magné N
Oral Oncol 2022 Jun;129:105868. Epub 2022 May 2 doi: 10.1016/j.oraloncology.2022.105868. PMID: 35512488
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Head and neck cancer: causes, prevention and treatment.
Galbiatti AL, Padovani-Junior JA, Maníglia JV, Rodrigues CD, Pavarino ÉC, Goloni-Bertollo EM
Braz J Otorhinolaryngol 2013 Mar-Apr;79(2):239-47. doi: 10.5935/1808-8694.20130041. PMID: 23670332Free PMC Article
Human papillomavirus, smoking, and head and neck cancer.
Sinha P, Logan HL, Mendenhall WM
Am J Otolaryngol 2012 Jan-Feb;33(1):130-6. Epub 2011 May 5 doi: 10.1016/j.amjoto.2011.02.001. PMID: 21546122Free PMC Article
Re-irradiation of head and neck carcinoma.
Mendenhall WM, Mendenhall CM, Malyapa RS, Palta JR, Mendenhall NP
Am J Clin Oncol 2008 Aug;31(4):393-8. doi: 10.1097/COC.0b013e3181637398. PMID: 18846001

Diagnosis

Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Exosomes in head and neck cancer: Roles, mechanisms and applications.
Cao J, Zhang M, Xie F, Lou J, Zhou X, Zhang L, Fang M, Zhou F
Cancer Lett 2020 Dec 1;494:7-16. Epub 2020 Aug 8 doi: 10.1016/j.canlet.2020.07.005. PMID: 32781015
Head and neck carcinoma of unknown primary.
Kennel T, Garrel R, Costes V, Boisselier P, Crampette L, Favier V
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Jun;136(3):185-192. Epub 2019 Apr 17 doi: 10.1016/j.anorl.2019.04.002. PMID: 31005456
Referred otalgia.
Yanagisawa K, Kveton JF
Am J Otolaryngol 1992 Nov-Dec;13(6):323-7. doi: 10.1016/0196-0709(92)90072-2. PMID: 1443387

Therapy

Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment.
Derry JMJ, Burns C, Frazier JP, Beirne E, Grenley M, DuFort CC, Killingbeck E, Leon M, Williams C, Gregory M, Houlton J, Clayburgh D, Swiecicki P, Huszar D, Berger A, Klinghoffer RA
Clin Cancer Res 2023 Sep 15;29(18):3813-3825. doi: 10.1158/1078-0432.CCR-23-0827. PMID: 37389981Free PMC Article
Human papillomavirus-related oropharyngeal carcinoma.
Saito Y, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R
Jpn J Clin Oncol 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049. PMID: 35383359
Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial.
Bourhis J, Sire C, Graff P, Grégoire V, Maingon P, Calais G, Gery B, Martin L, Alfonsi M, Desprez P, Pignon T, Bardet E, Rives M, Geoffrois L, Daly-Schveitzer N, Sen S, Tuchais C, Dupuis O, Guerif S, Lapeyre M, Favrel V, Hamoir M, Lusinchi A, Temam S, Pinna A, Tao YG, Blanchard P, Aupérin A
Lancet Oncol 2012 Feb;13(2):145-53. Epub 2012 Jan 18 doi: 10.1016/S1470-2045(11)70346-1. PMID: 22261362
Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system.
Levin VA, Bidaut L, Hou P, Kumar AJ, Wefel JS, Bekele BN, Grewal J, Prabhu S, Loghin M, Gilbert MR, Jackson EF
Int J Radiat Oncol Biol Phys 2011 Apr 1;79(5):1487-95. doi: 10.1016/j.ijrobp.2009.12.061. PMID: 20399573Free PMC Article

Prognosis

Human papillomavirus-related oropharyngeal carcinoma.
Saito Y, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R
Jpn J Clin Oncol 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049. PMID: 35383359
PD-L1 expression in recurrent head and neck squamous cell carcinoma.
Delafoy A, Uguen A, Lemasson G, Conan-Charlet V, Pradier O, Lucia F, Schick U
Eur Arch Otorhinolaryngol 2022 Jan;279(1):343-351. Epub 2021 Apr 1 doi: 10.1007/s00405-021-06777-7. PMID: 33796940
Exosomes in head and neck cancer: Roles, mechanisms and applications.
Cao J, Zhang M, Xie F, Lou J, Zhou X, Zhang L, Fang M, Zhou F
Cancer Lett 2020 Dec 1;494:7-16. Epub 2020 Aug 8 doi: 10.1016/j.canlet.2020.07.005. PMID: 32781015
The 5-Ws of immunotherapy in head and neck cancer.
Botticelli A, Mezi S, Pomati G, Cerbelli B, Di Rocco C, Amirhassankhani S, Sirgiovanni G, Occhipinti M, Napoli V, Emiliani A, Mazzuca F, Tomao S, Nuti M, Marchetti P
Crit Rev Oncol Hematol 2020 Sep;153:103041. Epub 2020 Jun 30 doi: 10.1016/j.critrevonc.2020.103041. PMID: 32629362
Head and Neck Carcinoma Immunotherapy: Facts and Hopes.
Whiteside TL
Clin Cancer Res 2018 Jan 1;24(1):6-13. Epub 2017 Jul 27 doi: 10.1158/1078-0432.CCR-17-1261. PMID: 28751445Free PMC Article

Clinical prediction guides

Prediction of Necroptosis-Related Markers in Head and Neck Carcinoma by Bioinformatics.
Zheng L, Li M, Gu R, Zhang H, Qi X, Dong H
J Immunol Res 2022;2022:1993023. Epub 2022 Jun 22 doi: 10.1155/2022/1993023. PMID: 35785035Free PMC Article
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
The 5-Ws of immunotherapy in head and neck cancer.
Botticelli A, Mezi S, Pomati G, Cerbelli B, Di Rocco C, Amirhassankhani S, Sirgiovanni G, Occhipinti M, Napoli V, Emiliani A, Mazzuca F, Tomao S, Nuti M, Marchetti P
Crit Rev Oncol Hematol 2020 Sep;153:103041. Epub 2020 Jun 30 doi: 10.1016/j.critrevonc.2020.103041. PMID: 32629362
Immunotherapy of solid tumors: safety of treatment.
Domagała-Kulawik J, Leszek P, Owczarek W, Rawa T, Stelmachowska-Banaś M, Rutkowski P
Pol Arch Intern Med 2020 Sep 30;130(9):766-778. Epub 2020 Apr 24 doi: 10.20452/pamw.15314. PMID: 32329982
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent systematic reviews

Pharmacological PI3K inhibition in head and neck squamous cell carcinoma: A systematic review.
Alves LB, Moura AC, Amorim Dos Santos J, Borges GA, Guerra ENS
Toxicol In Vitro 2023 Apr;88:105558. Epub 2023 Jan 18 doi: 10.1016/j.tiv.2023.105558. PMID: 36681288
Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment.
Wang T, Liu X, Ng YY, Tarleton K, Tran A, Tran T, Xue WY, Youssef P, Yuan P, Zhang D, Paolini R, Celentano A
Biomolecules 2022 Feb 10;12(2) doi: 10.3390/biom12020290. PMID: 35204791Free PMC Article
Anti-PD-1 and Anti-PD-L1 in Head and Neck Cancer: A Network Meta-Analysis.
Botticelli A, Cirillo A, Strigari L, Valentini F, Cerbelli B, Scagnoli S, Cerbelli E, Zizzari IG, Rocca CD, D'Amati G, Polimeni A, Nuti M, Merlano MC, Mezi S, Marchetti P
Front Immunol 2021;12:705096. Epub 2021 Aug 9 doi: 10.3389/fimmu.2021.705096. PMID: 34434192Free PMC Article
Chemotherapy and immunotherapy for recurrent and metastatic head and neck cancer: a systematic review.
Guidi A, Codecà C, Ferrari D
Med Oncol 2018 Feb 13;35(3):37. doi: 10.1007/s12032-018-1096-5. PMID: 29441454
In vivo and in vitro effects of curcumin on head and neck carcinoma: a systematic review.
Borges GÁ, Rêgo DF, Assad DX, Coletta RD, De Luca Canto G, Guerra EN
J Oral Pathol Med 2017 Jan;46(1):3-20. Epub 2016 May 24 doi: 10.1111/jop.12455. PMID: 27219631

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