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Recurrent Laryngeal Squamous Cell Carcinoma

MedGen UID:
79114
•Concept ID:
C0280401
•
Neoplastic Process
Synonyms: Recurrent Epidermoid Carcinoma of Larynx; Recurrent Epidermoid Carcinoma of the Larynx; Recurrent Laryngeal Epidermoid Carcinoma; Recurrent Larynx Epidermoid Carcinoma; Recurrent Larynx Squamous Cell Carcinoma; Recurrent Squamous Cell Carcinoma of Larynx; Recurrent Squamous Cell Carcinoma of the Larynx; Relapsed Epidermoid Carcinoma of Larynx; Relapsed Epidermoid Carcinoma of the Larynx; Relapsed Laryngeal Epidermoid Carcinoma; Relapsed Laryngeal Squamous Cell Carcinoma; Relapsed Larynx Epidermoid Carcinoma; Relapsed Larynx Squamous Cell Carcinoma; Relapsed Squamous Cell Carcinoma of Larynx; Relapsed Squamous Cell Carcinoma of the Larynx

Definition

The reemergence of squamous cell carcinoma of the larynx after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Laryngeal Squamous Cell Carcinoma

Professional guidelines

PubMed

Salvage carbon dioxide transoral laser microsurgery for laryngeal cancer after (chemo)radiotherapy: a European Laryngological Society consensus statement.
Piazza C, Paderno A, Sjogren EV, Bradley PJ, Eckel HE, Mäkitie A, Matar N, Paleri V, Peretti G, Puxeddu R, Quer M, Remacle M, Vander Poorten V, Vilaseca I, Simo R
Eur Arch Otorhinolaryngol 2021 Nov;278(11):4373-4381. Epub 2021 Jul 5 doi: 10.1007/s00405-021-06957-5. PMID: 34226992Free PMC Article
Boron Neutron Capture Therapy in the Treatment of Recurrent Laryngeal Cancer.
Haapaniemi A, Kankaanranta L, Saat R, Koivunoro H, Saarilahti K, Mäkitie A, Atula T, Joensuu H
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):404-410. Epub 2015 Nov 10 doi: 10.1016/j.ijrobp.2015.11.010. PMID: 26797537
Management of the N0 neck in recurrent laryngeal squamous cell carcinoma.
Bohannon IA, Desmond RA, Clemons L, Magnuson JS, Carroll WR, Rosenthal EL
Laryngoscope 2010 Jan;120(1):58-61. doi: 10.1002/lary.20675. PMID: 19877259

Recent clinical studies

Etiology

Prognostic value of CD103(+) tumor-infiltrating lymphocytes and programmed death ligand-1 (PD-L1) combined positive score in recurrent laryngeal squamous cell carcinoma.
Smith JD, Bellile EL, Ellsperman SE, Heft-Neal ME, Mann JE, Birkeland AC, Hoesli RC, Swiecicki PL, Worden FP, Schonewolf C, Shah JL, Mierzwa ML, Rosko AJ, Stucken CL, Chinn SB, Shuman AG, Casper KA, Malloy KM, Prince MEP, Wolf GT, Thomas DG, McHugh JB, Chad Brenner J, Spector ME
Oral Oncol 2022 Dec;135:106226. Epub 2022 Oct 28 doi: 10.1016/j.oraloncology.2022.106226. PMID: 36323071Free PMC Article
Mutational profiles of persistent/recurrent laryngeal squamous cell carcinoma.
Smith JD, Birkeland AC, Rosko AJ, Hoesli RC, Foltin SK, Swiecicki P, Mierzwa M, Chinn SB, Shuman AG, Malloy KM, Casper KA, McLean SA, Wolf GT, Bradford CR, Prince ME, Brenner JC, Spector ME
Head Neck 2019 Feb;41(2):423-428. Epub 2018 Dec 12 doi: 10.1002/hed.25444. PMID: 30548484Free PMC Article
Salvage total laryngectomy after conservation laryngeal surgery for recurrent laryngeal squamous cell carcinoma.
De Virgilio A, Greco A, Bussu F, Gallo A, Rosati D, Kim SH, Wang CC, Conte M, Pagliuca G, De Vincentiis M
Acta Otorhinolaryngol Ital 2016 Oct;36(5):373-380. doi: 10.14639/0392-100X-749. PMID: 27958597Free PMC Article
Intraoperative opioids use for laryngeal squamous cell carcinoma surgery and recurrence: a retrospective study.
Cata JP, Zafereo M, Villarreal J, Unruh BD, Truong A, Truong DT, Feng L, Gottumukkala V
J Clin Anesth 2015 Dec;27(8):672-9. Epub 2015 Sep 12 doi: 10.1016/j.jclinane.2015.07.012. PMID: 26371714
Recurrent laryngeal squamous cell carcinoma: rTNM versus composite laryngeal recurrence staging system. Proposal for a modification of the CLRSS to improve patient classification.
León X, López M, García J, Viza I, Gich I, Quer M
Head Neck 2008 Jul;30(7):939-45. doi: 10.1002/hed.20798. PMID: 18302258

Diagnosis

Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy.
Birkeland AC, Rosko AJ, Issa MR, Shuman AG, Prince ME, Wolf GT, Bradford CR, McHugh JB, Brenner JC, Spector ME
Otolaryngol Head Neck Surg 2016 Mar;154(3):473-9. Epub 2016 Feb 16 doi: 10.1177/0194599815627811. PMID: 26884365Free PMC Article
Which is the most reliable diagnostic modality for detecting locally residual or recurrent laryngeal squamous cell carcinoma after (chemo)radiotherapy?
Zbären P, de Bree R, Takes RP, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2013 Nov;270(11):2787-91. Epub 2013 May 21 doi: 10.1007/s00405-013-2564-3. PMID: 23689805
Recurrent laryngeal squamous cell carcinoma: rTNM versus composite laryngeal recurrence staging system. Proposal for a modification of the CLRSS to improve patient classification.
León X, López M, García J, Viza I, Gich I, Quer M
Head Neck 2008 Jul;30(7):939-45. doi: 10.1002/hed.20798. PMID: 18302258
Urinary N-acetyl-beta-D-glucosaminidase levels in patients with laryngeal squamous cell carcinoma.
Oktem F, Yazicilar O, Güvenç MG, Toprak M, Uzun H, Aydin S, Uslu E
J Otolaryngol 2007 Aug;36(4):233-9. PMID: 17942038
Validation of the Composite Laryngeal Recurrence Staging System.
Lacy PD, Kennedy JT, Piccirillo JF
Cancer 2004 Aug 15;101(4):761-7. doi: 10.1002/cncr.20438. PMID: 15305407

Therapy

Elective Paratracheal Lymph Node Dissection in Salvage Laryngectomy.
Farlow JL, Birkeland AC, Rosko AJ, VanKoevering K, Haring CT, Smith JD, Brenner JC, Shuman AG, Chinn SB, Stucken CL, Malloy KM, Moyer JS, Casper KA, McLean SA, Prince MEP, Bradford CR, Wolf GT, Chepeha DB, Spector ME
Ann Surg Oncol 2019 Aug;26(8):2542-2548. Epub 2019 Mar 4 doi: 10.1245/s10434-019-07270-6. PMID: 30830535Free PMC Article
Hypothyroidism and Wound Healing After Salvage Laryngectomy.
Rosko AJ, Birkeland AC, Bellile E, Kovatch KJ, Miller AL, Jaffe CC, Shuman AG, Chinn SB, Stucken CL, Malloy KM, Moyer JS, Casper KA, Prince MEP, Bradford CR, Wolf GT, Chepeha DB, Spector ME
Ann Surg Oncol 2018 May;25(5):1288-1295. Epub 2017 Dec 20 doi: 10.1245/s10434-017-6278-4. PMID: 29264671Free PMC Article
Open partial horizontal laryngectomy for salvage after failure of CO₂ laser-assisted surgery for glottic carcinoma.
Lucioni M, Bertolin A, Lionello M, Giacomelli L, Rizzotto G, Marioni G
Eur Arch Otorhinolaryngol 2016 Jan;273(1):169-75. Epub 2015 Aug 21 doi: 10.1007/s00405-015-3734-2. PMID: 26294221
Intraoperative opioids use for laryngeal squamous cell carcinoma surgery and recurrence: a retrospective study.
Cata JP, Zafereo M, Villarreal J, Unruh BD, Truong A, Truong DT, Feng L, Gottumukkala V
J Clin Anesth 2015 Dec;27(8):672-9. Epub 2015 Sep 12 doi: 10.1016/j.jclinane.2015.07.012. PMID: 26371714
LOH detected by microsatellite markers reveals the clonal origin of recurrent laryngeal squamous cell carcinoma.
Cui Z, Pan X, Wang Q
PLoS One 2014;9(11):e111857. Epub 2014 Nov 3 doi: 10.1371/journal.pone.0111857. PMID: 25365429Free PMC Article

Prognosis

Prognostic value of CD103(+) tumor-infiltrating lymphocytes and programmed death ligand-1 (PD-L1) combined positive score in recurrent laryngeal squamous cell carcinoma.
Smith JD, Bellile EL, Ellsperman SE, Heft-Neal ME, Mann JE, Birkeland AC, Hoesli RC, Swiecicki PL, Worden FP, Schonewolf C, Shah JL, Mierzwa ML, Rosko AJ, Stucken CL, Chinn SB, Shuman AG, Casper KA, Malloy KM, Prince MEP, Wolf GT, Thomas DG, McHugh JB, Chad Brenner J, Spector ME
Oral Oncol 2022 Dec;135:106226. Epub 2022 Oct 28 doi: 10.1016/j.oraloncology.2022.106226. PMID: 36323071Free PMC Article
Salvage surgery for residual or recurrent laryngeal squamous cell carcinoma after (Chemo)radiotherapy: Oncological outcomes and prognostic factors.
Vander Poorten V, Meulemans J, Beitler JJ, Piazza C, Kowalski LP, Mäkitie AA, Paleri V, Rinaldo A, Robbins KT, Rodrigo JP, Silver CE, Sjögren EV, Strojan P, Takes RP, Ferlito A
Eur J Surg Oncol 2021 Nov;47(11):2711-2721. Epub 2021 May 26 doi: 10.1016/j.ejso.2021.05.035. PMID: 34059377
Mutational profiles of persistent/recurrent laryngeal squamous cell carcinoma.
Smith JD, Birkeland AC, Rosko AJ, Hoesli RC, Foltin SK, Swiecicki P, Mierzwa M, Chinn SB, Shuman AG, Malloy KM, Casper KA, McLean SA, Wolf GT, Bradford CR, Prince ME, Brenner JC, Spector ME
Head Neck 2019 Feb;41(2):423-428. Epub 2018 Dec 12 doi: 10.1002/hed.25444. PMID: 30548484Free PMC Article
Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma.
Mann JE, Smith JD, Birkeland AC, Bellile E, Swiecicki P, Mierzwa M, Chinn SB, Shuman AG, Malloy KM, Casper KA, McLean SA, Moyer JS, Wolf GT, Bradford CR, Prince ME, Carey TE, McHugh JB, Spector ME, Brenner JC
Cancer Immunol Immunother 2019 Feb;68(2):213-220. Epub 2018 Oct 25 doi: 10.1007/s00262-018-2256-3. PMID: 30361882Free PMC Article
Recurrent laryngeal squamous cell carcinoma: rTNM versus composite laryngeal recurrence staging system. Proposal for a modification of the CLRSS to improve patient classification.
León X, López M, García J, Viza I, Gich I, Quer M
Head Neck 2008 Jul;30(7):939-45. doi: 10.1002/hed.20798. PMID: 18302258

Clinical prediction guides

Prognostic value of CD103(+) tumor-infiltrating lymphocytes and programmed death ligand-1 (PD-L1) combined positive score in recurrent laryngeal squamous cell carcinoma.
Smith JD, Bellile EL, Ellsperman SE, Heft-Neal ME, Mann JE, Birkeland AC, Hoesli RC, Swiecicki PL, Worden FP, Schonewolf C, Shah JL, Mierzwa ML, Rosko AJ, Stucken CL, Chinn SB, Shuman AG, Casper KA, Malloy KM, Prince MEP, Wolf GT, Thomas DG, McHugh JB, Chad Brenner J, Spector ME
Oral Oncol 2022 Dec;135:106226. Epub 2022 Oct 28 doi: 10.1016/j.oraloncology.2022.106226. PMID: 36323071Free PMC Article
Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma.
Mann JE, Smith JD, Birkeland AC, Bellile E, Swiecicki P, Mierzwa M, Chinn SB, Shuman AG, Malloy KM, Casper KA, McLean SA, Moyer JS, Wolf GT, Bradford CR, Prince ME, Carey TE, McHugh JB, Spector ME, Brenner JC
Cancer Immunol Immunother 2019 Feb;68(2):213-220. Epub 2018 Oct 25 doi: 10.1007/s00262-018-2256-3. PMID: 30361882Free PMC Article
Proportion of CD4 and CD8 tumor infiltrating lymphocytes predicts survival in persistent/recurrent laryngeal squamous cell carcinoma.
Hoesli R, Birkeland AC, Rosko AJ, Issa M, Chow KL, Michmerhuizen NL, Mann JE, Chinn SB, Shuman AG, Prince ME, Wolf GT, Bradford CR, McHugh JB, Brenner JC, Spector ME
Oral Oncol 2018 Feb;77:83-89. Epub 2017 Dec 23 doi: 10.1016/j.oraloncology.2017.12.003. PMID: 29362129Free PMC Article
Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy.
Birkeland AC, Rosko AJ, Issa MR, Shuman AG, Prince ME, Wolf GT, Bradford CR, McHugh JB, Brenner JC, Spector ME
Otolaryngol Head Neck Surg 2016 Mar;154(3):473-9. Epub 2016 Feb 16 doi: 10.1177/0194599815627811. PMID: 26884365Free PMC Article
Intraoperative opioids use for laryngeal squamous cell carcinoma surgery and recurrence: a retrospective study.
Cata JP, Zafereo M, Villarreal J, Unruh BD, Truong A, Truong DT, Feng L, Gottumukkala V
J Clin Anesth 2015 Dec;27(8):672-9. Epub 2015 Sep 12 doi: 10.1016/j.jclinane.2015.07.012. PMID: 26371714

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