U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Lip Squamous Cell Carcinoma

MedGen UID:
1659624
•Concept ID:
C4744560
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the lip and has metastasized to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Lip Squamous Cell Carcinoma

Professional guidelines

PubMed

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Lip cancer: Reconsidering the at-risk patients with pathological assessment.
Ant A, Kilic C, Baltu Y, Duran AB, Tunccan T, Ozlugedik S, Bozdogan N
Oral Dis 2019 Apr;25(3):742-749. Epub 2019 Jan 23 doi: 10.1111/odi.13017. PMID: 30548899
Cheilitis glandularis: clinico-histopathological diagnostic criteria.
Reiter S, Vered M, Yarom N, Goldsmith C, Gorsky M
Oral Dis 2011 Apr;17(3):335-9. Epub 2010 Oct 28 doi: 10.1111/j.1601-0825.2010.01762.x. PMID: 21029266

Recent clinical studies

Etiology

Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study.
Knuutila JS, Riihilä P, Kurki S, Nissinen L, Kähäri VM
Acta Derm Venereol 2020 Sep 23;100(16):adv00266. doi: 10.2340/00015555-3628. PMID: 32930344Free PMC Article
Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England.
Venables ZC, Autier P, Nijsten T, Wong KF, Langan SM, Rous B, Broggio J, Harwood C, Henson K, Proby CM, Rashbass J, Leigh IM
JAMA Dermatol 2019 Mar 1;155(3):298-306. doi: 10.1001/jamadermatol.2018.4219. PMID: 30484823Free PMC Article
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Squamous cell carcinoma of the lip: survival analysis with long-term follow-up.
Ozturk K, Gode S, Erdogan U, Akyildiz S, Apaydin F
Eur Arch Otorhinolaryngol 2015 Nov;272(11):3545-50. Epub 2014 Dec 3 doi: 10.1007/s00405-014-3415-6. PMID: 25467011
Squamous cell carcinoma of the skin (excluding lip and oral mucosa).
Johnson TM, Rowe DE, Nelson BR, Swanson NA
J Am Acad Dermatol 1992 Mar;26(3 Pt 2):467-84. doi: 10.1016/0190-9622(92)70074-p. PMID: 1564155

Diagnosis

Aggressive squamous cell carcinoma of the lip.
Schnur J, Johnson Shaw ME, Carnio LR, Casadesus D
BMJ Case Rep 2020 Dec 17;13(12) doi: 10.1136/bcr-2020-239281. PMID: 33334769Free PMC Article
Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study.
Knuutila JS, Riihilä P, Kurki S, Nissinen L, Kähäri VM
Acta Derm Venereol 2020 Sep 23;100(16):adv00266. doi: 10.2340/00015555-3628. PMID: 32930344Free PMC Article
Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England.
Venables ZC, Autier P, Nijsten T, Wong KF, Langan SM, Rous B, Broggio J, Harwood C, Henson K, Proby CM, Rashbass J, Leigh IM
JAMA Dermatol 2019 Mar 1;155(3):298-306. doi: 10.1001/jamadermatol.2018.4219. PMID: 30484823Free PMC Article
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Lip squamous cell carcinoma in a Brazilian population: epidemiological study and clinicopathological associations.
Souza RL, Fonseca-Fonseca T, Oliveira-Santos CC, Corrêa GT, Santos FB, Cardoso CM, Sant' Ana-Haikal D, Guimarães AL, Batista-De Paula AM
Med Oral Patol Oral Cir Bucal 2011 Sep 1;16(6):e757-62. doi: 10.4317/medoral.16954. PMID: 21196879

Therapy

Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.
Powell SF, Gold KA, Gitau MM, Sumey CJ, Lohr MM, McGraw SC, Nowak RK, Jensen AW, Blanchard MJ, Fischer CD, Bykowski J, Ellison CA, Black LJ, Thompson PA, Callejas-Valera JL, Lee JH, Cohen EEW, Spanos WC
J Clin Oncol 2020 Jul 20;38(21):2427-2437. Epub 2020 Jun 1 doi: 10.1200/JCO.19.03156. PMID: 32479189Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Cervical lymph node metastases and T1 squamous cell carcinoma of the lips.
Bon-Mardion N, De Raucourt D, Babin E, Rame JP, Dehesdin D, Choussy O
B-ENT 2015;11(2):89-93. PMID: 26563007
Treatment of squamous cell carcinoma of the lip using Foscan-mediated photodynamic therapy.
Kübler AC, de Carpentier J, Hopper C, Leonard AG, Putnam G
Int J Oral Maxillofac Surg 2001 Dec;30(6):504-9. doi: 10.1054/ijom.2001.0160. PMID: 11829232
Carcinoma of the lip.
Wurman LH, Adams GL, Meyerhoff WL
Am J Surg 1975 Oct;130(4):470-4. doi: 10.1016/0002-9610(75)90486-9. PMID: 1101725

Prognosis

Aggressive squamous cell carcinoma of the lip.
Schnur J, Johnson Shaw ME, Carnio LR, Casadesus D
BMJ Case Rep 2020 Dec 17;13(12) doi: 10.1136/bcr-2020-239281. PMID: 33334769Free PMC Article
Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study.
Knuutila JS, Riihilä P, Kurki S, Nissinen L, Kähäri VM
Acta Derm Venereol 2020 Sep 23;100(16):adv00266. doi: 10.2340/00015555-3628. PMID: 32930344Free PMC Article
Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England.
Venables ZC, Autier P, Nijsten T, Wong KF, Langan SM, Rous B, Broggio J, Harwood C, Henson K, Proby CM, Rashbass J, Leigh IM
JAMA Dermatol 2019 Mar 1;155(3):298-306. doi: 10.1001/jamadermatol.2018.4219. PMID: 30484823Free PMC Article
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
Bota JP, Lyons AB, Carroll BT
Dermatol Surg 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. PMID: 28157733
Squamous cell carcinoma of the lip: survival analysis with long-term follow-up.
Ozturk K, Gode S, Erdogan U, Akyildiz S, Apaydin F
Eur Arch Otorhinolaryngol 2015 Nov;272(11):3545-50. Epub 2014 Dec 3 doi: 10.1007/s00405-014-3415-6. PMID: 25467011

Clinical prediction guides

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England.
Venables ZC, Autier P, Nijsten T, Wong KF, Langan SM, Rous B, Broggio J, Harwood C, Henson K, Proby CM, Rashbass J, Leigh IM
JAMA Dermatol 2019 Mar 1;155(3):298-306. doi: 10.1001/jamadermatol.2018.4219. PMID: 30484823Free PMC Article
Participation of hypoxia-inducible factor-1α and lymphangiogenesis in metastatic and non-metastatic lower lip squamous cell carcinoma.
de Aquino Martins ARL, Santos HBP, Mafra RP, Nonaka CFW, Souza LB, Pinto LP
J Craniomaxillofac Surg 2018 Oct;46(10):1741-1747. Epub 2018 Jul 29 doi: 10.1016/j.jcms.2018.07.020. PMID: 30119998
Squamous cell carcinoma of the lip: survival analysis with long-term follow-up.
Ozturk K, Gode S, Erdogan U, Akyildiz S, Apaydin F
Eur Arch Otorhinolaryngol 2015 Nov;272(11):3545-50. Epub 2014 Dec 3 doi: 10.1007/s00405-014-3415-6. PMID: 25467011
Lip squamous cell carcinoma in a Brazilian population: epidemiological study and clinicopathological associations.
Souza RL, Fonseca-Fonseca T, Oliveira-Santos CC, Corrêa GT, Santos FB, Cardoso CM, Sant' Ana-Haikal D, Guimarães AL, Batista-De Paula AM
Med Oral Patol Oral Cir Bucal 2011 Sep 1;16(6):e757-62. doi: 10.4317/medoral.16954. PMID: 21196879

Recent systematic reviews

Immunohistochemical analysis of epithelium adjacent to lip cancer: A meta-analysis.
Varela-Centelles P, Gonzalez-Moles MÁ, Seoane-Romero J, Leira-Feijoo Y, Takkouche B, Seoane-Romero JM
Oral Dis 2022 Jan;28(1):57-65. Epub 2020 Oct 5 doi: 10.1111/odi.13643. PMID: 32945581
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Walsh T, Macey R, Kerr AR, Lingen MW, Ogden GR, Warnakulasuriya S
Cochrane Database Syst Rev 2021 Jul 20;7(7):CD010276. doi: 10.1002/14651858.CD010276.pub3. PMID: 34282854Free PMC Article
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...