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Recurrent Pharyngeal Squamous Cell Carcinoma

MedGen UID:
1753201
•Concept ID:
C5420340
•
Neoplastic Process

Definition

The reemergence of pharyngeal squamous cell carcinoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Outcomes of Endoscopic Submucosal Dissection for Treatment of Superficial Pharyngeal Cancers: Systematic Review and Meta-Analysis.
Kamal F, Khan MA, Lee-Smith W, Sharma S, Imam Z, Jowhar D, Petryna E, Esswein J, Acharya A, Aziz M, Farooq U, Zafar U, Mcdonough S, Adler DG
Dig Dis Sci 2022 Aug;67(8):3518-3528. Epub 2021 Sep 9 doi: 10.1007/s10620-021-07225-6. PMID: 34505257
Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.
Grégoire V, Grau C, Lapeyre M, Maingon P
Oral Oncol 2018 Dec;87:131-137. Epub 2018 Nov 3 doi: 10.1016/j.oraloncology.2018.10.034. PMID: 30527228
ACR Appropriateness Criteria(®) Locoregional therapy for resectable oropharyngeal squamous cell carcinomas.
Beitler JJ, Quon H, Jones CU, Salama JK, Busse PM, Cooper JS, Koyfman SA, Ridge JA, Saba NF, Siddiqui F, Smith RV, Worden F, Yao M, Yom SS; Expert Panel on Radiation Oncology - Head and Neck
Head Neck 2016 Sep;38(9):1299-309. Epub 2016 Jun 22 doi: 10.1002/hed.24447. PMID: 27330003

Recent clinical studies

Etiology

Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
Tumour Cell Anaplasia and Multinucleation as Prognosticators in Oropharyngeal Squamous Cell Carcinoma.
Molony P, Werner R, Martin C, Callanan D, Sheahan P, Heffron C, Feeley L
Head Neck Pathol 2020 Sep;14(3):606-615. Epub 2019 Sep 24 doi: 10.1007/s12105-019-01081-7. PMID: 31552619Free PMC Article
Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.
Grégoire V, Grau C, Lapeyre M, Maingon P
Oral Oncol 2018 Dec;87:131-137. Epub 2018 Nov 3 doi: 10.1016/j.oraloncology.2018.10.034. PMID: 30527228
Pharyngotomy in head and neck squamous cell carcinoma: functional and oncological aspects.
Remmert C, Mansour N, Hofauer B, Scherer EQ, Bas M, Bier H, Knopf A
Acta Otolaryngol 2017 Dec;137(12):1281-1287. Epub 2017 Jul 25 doi: 10.1080/00016489.2017.1355564. PMID: 28743201
Oral cavity and oropharynx tumors.
Stambuk HE, Karimi S, Lee N, Patel SG
Radiol Clin North Am 2007 Jan;45(1):1-20. doi: 10.1016/j.rcl.2006.10.010. PMID: 17157621

Diagnosis

Personalizing Surveillance in Head and Neck Cancer.
Hanna GJ, Patel N, Tedla SG, Baugnon KL, Aiken A, Agrawal N
Am Soc Clin Oncol Educ Book 2023 Jan;43:e389718. doi: 10.1200/EDBK_389718. PMID: 37079869
Head and neck cancer: Current challenges and future perspectives.
Bhat GR, Hyole RG, Li J
Adv Cancer Res 2021;152:67-102. Epub 2021 Jun 16 doi: 10.1016/bs.acr.2021.05.002. PMID: 34353444
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Serum, plasma and saliva biomarkers for head and neck cancer.
Arantes LMRB, De Carvalho AC, Melendez ME, Lopes Carvalho A
Expert Rev Mol Diagn 2018 Jan;18(1):85-112. Epub 2017 Nov 20 doi: 10.1080/14737159.2017.1404906. PMID: 29134827
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Therapy

Neoadjuvant chemotherapy and transoral robotic surgery for the posterior pharyngeal wall carcinoma.
Costantino A, Meliante PG, Sampieri C, Lee K, Ralli M, De Vincentiis M, De Virgilio A, Kim SH
Eur Arch Otorhinolaryngol 2023 Oct;280(10):4649-4655. Epub 2023 Jul 3 doi: 10.1007/s00405-023-08070-1. PMID: 37395758
Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
Human papillomavirus oropharynx carcinoma: Aggressive de-escalation of adjuvant therapy.
Moore EJ, Van Abel KM, Routman DM, Lohse CM, Price KAR, Neben-Wittich M, Chintakuntlawar AV, Price DL, Kasperbauer JL, Garcia JJ, Hinni ML, Patel SH, Janus JR, Foote RL, Ma DJ
Head Neck 2021 Jan;43(1):229-237. Epub 2020 Sep 23 doi: 10.1002/hed.26477. PMID: 32969095
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Photodynamic therapy and the treatment of head and neck cancers.
Biel MA
J Clin Laser Med Surg 1996 Oct;14(5):239-44. doi: 10.1089/clm.1996.14.239. PMID: 9612189

Prognosis

Elevated LSD1 and SNAIL Expression Indicate Poor Prognosis in Hypopharynx Carcinoma.
Bottner J, Ribbat-Idel J, Klapper L, Jagomast T, Lemster AL, Perner S, Idel C, Kirfel J
Int J Mol Sci 2022 May 3;23(9) doi: 10.3390/ijms23095075. PMID: 35563463Free PMC Article
Head and neck cancer: Current challenges and future perspectives.
Bhat GR, Hyole RG, Li J
Adv Cancer Res 2021;152:67-102. Epub 2021 Jun 16 doi: 10.1016/bs.acr.2021.05.002. PMID: 34353444
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Serum, plasma and saliva biomarkers for head and neck cancer.
Arantes LMRB, De Carvalho AC, Melendez ME, Lopes Carvalho A
Expert Rev Mol Diagn 2018 Jan;18(1):85-112. Epub 2017 Nov 20 doi: 10.1080/14737159.2017.1404906. PMID: 29134827
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Clinical prediction guides

Head and neck cancer: Current challenges and future perspectives.
Bhat GR, Hyole RG, Li J
Adv Cancer Res 2021;152:67-102. Epub 2021 Jun 16 doi: 10.1016/bs.acr.2021.05.002. PMID: 34353444
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Opposing Effects of Heparanase and Heparanase-2 in Head & Neck Cancer.
Doweck I, Feibish N
Adv Exp Med Biol 2020;1221:847-856. doi: 10.1007/978-3-030-34521-1_37. PMID: 32274741
Tumour Cell Anaplasia and Multinucleation as Prognosticators in Oropharyngeal Squamous Cell Carcinoma.
Molony P, Werner R, Martin C, Callanan D, Sheahan P, Heffron C, Feeley L
Head Neck Pathol 2020 Sep;14(3):606-615. Epub 2019 Sep 24 doi: 10.1007/s12105-019-01081-7. PMID: 31552619Free PMC Article
Serum, plasma and saliva biomarkers for head and neck cancer.
Arantes LMRB, De Carvalho AC, Melendez ME, Lopes Carvalho A
Expert Rev Mol Diagn 2018 Jan;18(1):85-112. Epub 2017 Nov 20 doi: 10.1080/14737159.2017.1404906. PMID: 29134827

Recent systematic reviews

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Outcomes of Endoscopic Submucosal Dissection for Treatment of Superficial Pharyngeal Cancers: Systematic Review and Meta-Analysis.
Kamal F, Khan MA, Lee-Smith W, Sharma S, Imam Z, Jowhar D, Petryna E, Esswein J, Acharya A, Aziz M, Farooq U, Zafar U, Mcdonough S, Adler DG
Dig Dis Sci 2022 Aug;67(8):3518-3528. Epub 2021 Sep 9 doi: 10.1007/s10620-021-07225-6. PMID: 34505257
Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review.
Moumoulidis PT, Pavlopoulou A, Ünal R, Mavragani I, Georgakilas AG, Kyrodimos E
Front Biosci (Landmark Ed) 2021 Jul 30;26(7):235-245. doi: 10.52586/4937. PMID: 34340270
Impact of HPV Infection on the Immune System in Oropharyngeal and Non-Oropharyngeal Squamous Cell Carcinoma: A Systematic Review.
Lechien JR, Seminerio I, Descamps G, Mat Q, Mouawad F, Hans S, Julieron M, Dequanter D, Vanderhaegen T, Journe F, Saussez S
Cells 2019 Sep 10;8(9) doi: 10.3390/cells8091061. PMID: 31510065Free PMC Article
Sentinel node biopsy in squamous cell cancer of the oral cavity and oral pharynx: a diagnostic meta-analysis.
Paleri V, Rees G, Arullendran P, Shoaib T, Krishman S
Head Neck 2005 Sep;27(9):739-47. doi: 10.1002/hed.20228. PMID: 16047368

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