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Unresectable Nasopharyngeal Squamous Cell Carcinoma

MedGen UID:
1737201
Concept ID:
C5419760
Neoplastic Process

Definition

Nasopharyngeal squamous cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Nasopharyngeal Squamous Cell Carcinoma

Professional guidelines

PubMed

Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article
Forastiere AA
J Surg Oncol 2008 Jun 15;97(8):701-7. doi: 10.1002/jso.21012. PMID: 18493921
Lamont EB, Vokes EE
Lancet Oncol 2001 May;2(5):261-9. doi: 10.1016/S1470-2045(00)00320-X. PMID: 11905780

Recent clinical studies

Etiology

Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article
McDonald MW, Lawson J, Garg MK, Quon H, Ridge JA, Saba N, Salama JK, Smith RV, Yeung AR, Yom SS, Beitler JJ; Expert Panel on Radiation Oncology-Head and Neck Cancer
Int J Radiat Oncol Biol Phys 2011 Aug 1;80(5):1292-8. Epub 2011 Apr 27 doi: 10.1016/j.ijrobp.2011.02.014. PMID: 21530100
Forastiere AA
J Surg Oncol 2008 Jun 15;97(8):701-7. doi: 10.1002/jso.21012. PMID: 18493921
De Crevoisier R, Bourhis J, Domenge C, Wibault P, Koscielny S, Lusinchi A, Mamelle G, Janot F, Julieron M, Leridant AM, Marandas P, Armand JP, Schwaab G, Luboinski B, Eschwege F
J Clin Oncol 1998 Nov;16(11):3556-62. doi: 10.1200/JCO.1998.16.11.3556. PMID: 9817275
Vokes EE, Athanasiadis I
Ann Oncol 1996 Jan;7(1):15-29. doi: 10.1093/oxfordjournals.annonc.a010467. PMID: 9081382

Diagnosis

Omura G, Honma Y, Matsumoto Y, Shinozaki T, Itoyama M, Eguchi K, Sakai T, Yokoyama K, Watanabe T, Ohara A, Kato K, Yoshimoto S
Auris Nasus Larynx 2023 Aug;50(4):641-645. Epub 2022 Jun 29 doi: 10.1016/j.anl.2022.06.004. PMID: 35779979
Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article
Mallick S, Benson R, Bhasker S, Mohanti BK
J Cancer Res Ther 2015 Jan-Mar;11(1):73-7. doi: 10.4103/0973-1482.150349. PMID: 25879340
Xi M, Liu SL, Zhao L, Shen JX, Zhang L, Zhang P, Liu MZ
PLoS One 2013;8(12):e84586. Epub 2013 Dec 18 doi: 10.1371/journal.pone.0084586. PMID: 24367679Free PMC Article

Therapy

Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Teknos TN, Grecula J, Agrawal A, Old MO, Ozer E, Carrau R, Kang S, Rocco J, Blakaj D, Diavolitsis V, Kumar B, Kumar P, Pan Q, Palettas M, Wei L, Baiocchi R, Savvides P
Invest New Drugs 2019 Aug;37(4):702-710. Epub 2018 Dec 19 doi: 10.1007/s10637-018-0696-4. PMID: 30569244
Lamont EB, Vokes EE
Lancet Oncol 2001 May;2(5):261-9. doi: 10.1016/S1470-2045(00)00320-X. PMID: 11905780
Vokes EE, Athanasiadis I
Ann Oncol 1996 Jan;7(1):15-29. doi: 10.1093/oxfordjournals.annonc.a010467. PMID: 9081382
Dimery IW, Hong WK
J Natl Cancer Inst 1993 Jan 20;85(2):95-111. doi: 10.1093/jnci/85.2.95. PMID: 8418313

Prognosis

Wang M, Chen X, Tan P, Wang Y, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q, Wei Y, Liu Y, Chen C
Cancer Cell 2022 Sep 12;40(9):1044-1059.e8. doi: 10.1016/j.ccell.2022.08.010. PMID: 36099882
Sun Y
Mil Med Res 2019 Oct 25;6(1):32. doi: 10.1186/s40779-019-0224-7. PMID: 31651361Free PMC Article
Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article
Lamont EB, Vokes EE
Lancet Oncol 2001 May;2(5):261-9. doi: 10.1016/S1470-2045(00)00320-X. PMID: 11905780
Dimery IW, Hong WK
J Natl Cancer Inst 1993 Jan 20;85(2):95-111. doi: 10.1093/jnci/85.2.95. PMID: 8418313

Clinical prediction guides

Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Cengiz M, Özyiğit G, Yazici G, Doğan A, Yildiz F, Zorlu F, Gürkaynak M, Gullu IH, Hosal S, Akyol F
Int J Radiat Oncol Biol Phys 2011 Sep 1;81(1):104-9. Epub 2010 Aug 2 doi: 10.1016/j.ijrobp.2010.04.027. PMID: 20675075
De Crevoisier R, Bourhis J, Domenge C, Wibault P, Koscielny S, Lusinchi A, Mamelle G, Janot F, Julieron M, Leridant AM, Marandas P, Armand JP, Schwaab G, Luboinski B, Eschwege F
J Clin Oncol 1998 Nov;16(11):3556-62. doi: 10.1200/JCO.1998.16.11.3556. PMID: 9817275
Slotman GJ, Cummings FJ, Glicksman AR, Doolittle CL, Leone LA
Head Neck Surg 1986 Jan-Feb;8(3):159-64. doi: 10.1002/hed.2890080306. PMID: 3744847

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