U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma

MedGen UID:
1717441
•Concept ID:
C5234873
•
Neoplastic Process
Synonyms: Recurrent Keratinizing Epidermoid Carcinoma of Nasopharynx; Recurrent Keratinizing Epidermoid Carcinoma of the Nasopharynx; Recurrent Keratinizing Squamous Cell Carcinoma of Nasopharynx; Recurrent Keratinizing Squamous Cell Carcinoma of the Nasopharynx; Recurrent Nasopharyngeal Keratinizing Epidermoid Carcinoma; Relapsed Keratinizing Epidermoid Carcinoma of Nasopharynx; Relapsed Keratinizing Epidermoid Carcinoma of the Nasopharynx; Relapsed Keratinizing Squamous Cell Carcinoma of Nasopharynx; Relapsed Keratinizing Squamous Cell Carcinoma of the Nasopharynx; Relapsed Nasopharyngeal Keratinizing Epidermoid Carcinoma; Relapsed Nasopharyngeal Keratinizing Squamous Cell Carcinoma

Definition

The reemergence of keratinizing squamous cell carcinoma of the nasopharynx after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma

Professional guidelines

PubMed

The effect of FoxP3 on tumour stage, treatment response, recurrence and survivalability in nasopharynx cancer patients.
Kara İ, Çağlı S, Vural A, Yüce İ, Gündoğ M, Deniz K, Kökoğlu K
Clin Otolaryngol 2019 May;44(3):349-355. Epub 2019 Mar 12 doi: 10.1111/coa.13311. PMID: 30756505
Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828
Management to prevent high-sited recurrence of pharyngo-laryngeal cancers.
Remacle M, Robillard T, Deckers C, Mazy G, Hamoir M, Van de Eeckhaut J
Acta Otorhinolaryngol Belg 1984;38(5):464-73. PMID: 6535365

Recent clinical studies

Etiology

Re-irradiation with Moderate Hypo-fractionation Using Intensity Modulated Photon or Proton Radiation Therapy in Locally Recurrent Squamous Cell Carcinoma of Nasopharynx.
Nam H, Ahn YC, Yang K, Oh D, Noh JM
Cancer Res Treat 2022 Jan;54(1):96-108. Epub 2021 Mar 26 doi: 10.4143/crt.2020.1349. PMID: 33781049Free PMC Article
Prognostic value of the Epstein-Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinoma.
Liu J, Liu Y, Zhang Z, Sun H, Ji X, Li B, Zhou X, Gai P
J Cancer Res Ther 2019;15(2):426-436. doi: 10.4103/jcrt.JCRT_750_18. PMID: 30964122
Lymphoepithelioma-like carcinoma of the skin.
Cavalieri S, Feliciani C, Massi G, Addolorato G, Gasbarrini G, Amerio P, Rotoli M
Int J Immunopathol Pharmacol 2007 Oct-Dec;20(4):851-4. doi: 10.1177/039463200702000424. PMID: 18179760
The significance of keratinizing squamous cell histology in Chinese patients with nasopharyngeal carcinoma.
Chan AT, Teo ML, Lee WY, Kwan WH, Choi PH, Johnson PJ
Clin Oncol (R Coll Radiol) 1998;10(3):161-4. doi: 10.1016/s0936-6555(98)80057-5. PMID: 9704177
Salvage surgery for recurrent nasopharyngeal carcinoma.
Hsu MM, Ko JY, Sheen TS, Chang YL
Arch Otolaryngol Head Neck Surg 1997 Mar;123(3):305-9. doi: 10.1001/archotol.1997.01900030087011. PMID: 9076238

Diagnosis

Tumor-to-tumor metastasis: A case report of metastasis of nasopharyngeal carcinoma to meningioma and review of the literature.
Li X, Jing M, Dai Y, Xing X
Medicine (Baltimore) 2023 Apr 14;102(15):e33500. doi: 10.1097/MD.0000000000033500. PMID: 37058069Free PMC Article
A rare case of intracytoplasmic mucin-rich nasopharyngeal carcinoma.
Yamaguchi Y, Odate T, Nakazawa K, Oishi N, Mochizuki K, Shimizu T, Horiuchi K, Ishii H, Sakurai D, Kondo T
Diagn Cytopathol 2022 Jun;50(6):E151-E155. Epub 2022 Jan 31 doi: 10.1002/dc.24934. PMID: 35100480
Prognostic value of the Epstein-Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinoma.
Liu J, Liu Y, Zhang Z, Sun H, Ji X, Li B, Zhou X, Gai P
J Cancer Res Ther 2019;15(2):426-436. doi: 10.4103/jcrt.JCRT_750_18. PMID: 30964122
Undifferentiated nasopharyngeal cancer (UCNT): current diagnostic and therapeutic aspects.
Altun M, Fandi A, Dupuis O, Cvitkovic E, Krajina Z, Eschwege F
Int J Radiat Oncol Biol Phys 1995 Jun 15;32(3):859-77. doi: 10.1016/0360-3016(95)00516-2. PMID: 7790274
Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828

Therapy

Re-irradiation with Moderate Hypo-fractionation Using Intensity Modulated Photon or Proton Radiation Therapy in Locally Recurrent Squamous Cell Carcinoma of Nasopharynx.
Nam H, Ahn YC, Yang K, Oh D, Noh JM
Cancer Res Treat 2022 Jan;54(1):96-108. Epub 2021 Mar 26 doi: 10.4143/crt.2020.1349. PMID: 33781049Free PMC Article
Locoregional control after intensity-modulated radiotherapy for nasopharyngeal carcinoma with an anatomy-based target definition.
Kawashima M, Ariji T, Kameoka S, Ueda T, Kohno R, Nishio T, Arahira S, Motegi A, Zenda S, Akimoto T, Tahara M, Hayashi R
Jpn J Clin Oncol 2013 Dec;43(12):1218-25. Epub 2013 Sep 26 doi: 10.1093/jjco/hyt144. PMID: 24072854
The significance of keratinizing squamous cell histology in Chinese patients with nasopharyngeal carcinoma.
Chan AT, Teo ML, Lee WY, Kwan WH, Choi PH, Johnson PJ
Clin Oncol (R Coll Radiol) 1998;10(3):161-4. doi: 10.1016/s0936-6555(98)80057-5. PMID: 9704177
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma.
Chou YY, Lee WJ, Su CT, Hsu HC
J Gastroenterol Hepatol 1997 Mar;12(3):229-32. doi: 10.1111/j.1440-1746.1997.tb00413.x. PMID: 9142640
Undifferentiated nasopharyngeal cancer (UCNT): current diagnostic and therapeutic aspects.
Altun M, Fandi A, Dupuis O, Cvitkovic E, Krajina Z, Eschwege F
Int J Radiat Oncol Biol Phys 1995 Jun 15;32(3):859-77. doi: 10.1016/0360-3016(95)00516-2. PMID: 7790274

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Prognostic value of the Epstein-Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinoma.
Liu J, Liu Y, Zhang Z, Sun H, Ji X, Li B, Zhou X, Gai P
J Cancer Res Ther 2019;15(2):426-436. doi: 10.4103/jcrt.JCRT_750_18. PMID: 30964122
The significance of keratinizing squamous cell histology in Chinese patients with nasopharyngeal carcinoma.
Chan AT, Teo ML, Lee WY, Kwan WH, Choi PH, Johnson PJ
Clin Oncol (R Coll Radiol) 1998;10(3):161-4. doi: 10.1016/s0936-6555(98)80057-5. PMID: 9704177
Undifferentiated nasopharyngeal cancer (UCNT): current diagnostic and therapeutic aspects.
Altun M, Fandi A, Dupuis O, Cvitkovic E, Krajina Z, Eschwege F
Int J Radiat Oncol Biol Phys 1995 Jun 15;32(3):859-77. doi: 10.1016/0360-3016(95)00516-2. PMID: 7790274
Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828

Clinical prediction guides

Tumor-to-tumor metastasis: A case report of metastasis of nasopharyngeal carcinoma to meningioma and review of the literature.
Li X, Jing M, Dai Y, Xing X
Medicine (Baltimore) 2023 Apr 14;102(15):e33500. doi: 10.1097/MD.0000000000033500. PMID: 37058069Free PMC Article
A rare case of intracytoplasmic mucin-rich nasopharyngeal carcinoma.
Yamaguchi Y, Odate T, Nakazawa K, Oishi N, Mochizuki K, Shimizu T, Horiuchi K, Ishii H, Sakurai D, Kondo T
Diagn Cytopathol 2022 Jun;50(6):E151-E155. Epub 2022 Jan 31 doi: 10.1002/dc.24934. PMID: 35100480
Prognostic value of the Epstein-Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinoma.
Liu J, Liu Y, Zhang Z, Sun H, Ji X, Li B, Zhou X, Gai P
J Cancer Res Ther 2019;15(2):426-436. doi: 10.4103/jcrt.JCRT_750_18. PMID: 30964122
Epstein-Barr Virus-Associated Pulmonary Carcinoma: Proposing an Alternative Term and Expanding the Histologic Spectrum of Lymphoepithelioma-like Carcinoma of the Lung.
Yeh YC, Kao HL, Lee KL, Wu MH, Ho HL, Chou TY
Am J Surg Pathol 2019 Feb;43(2):211-219. doi: 10.1097/PAS.0000000000001173. PMID: 30334830
Clinical Outcomes of Several IMRT Techniques for Patients With Head and Neck Cancer: A Propensity Score-Weighted Analysis.
Bibault JE, Dussart S, Pommier P, Morelle M, Huguet M, Boisselier P, Coche-Dequeant B, Alfonsi M, Bardet E, Rives M, Calugaru V, Chajon E, Noel G, Mecellem H, Servagi Vernat S, Perrier L, Giraud P
Int J Radiat Oncol Biol Phys 2017 Nov 15;99(4):929-937. Epub 2017 Jun 27 doi: 10.1016/j.ijrobp.2017.06.2456. PMID: 28864403

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...