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Recurrent Nasopharyngeal Undifferentiated Carcinoma

MedGen UID:
83645
•Concept ID:
C0280387
•
Neoplastic Process
Synonyms: Recurrent Lymphoepithelioma of Nasopharynx; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Nasopharyngeal Lymphoepithelioma; Recurrent Undifferentiated Carcinoma of Nasopharynx; Recurrent Undifferentiated Carcinoma of the Nasopharynx; Relapsed Lymphoepithelioma of Nasopharynx; Relapsed Lymphoepithelioma of the Nasopharynx; Relapsed Nasopharyngeal Lymphoepithelioma; Relapsed Nasopharyngeal Undifferentiated Carcinoma; Relapsed Undifferentiated Carcinoma of Nasopharynx; Relapsed Undifferentiated Carcinoma of the Nasopharynx

Definition

The reemergence of undifferentiated carcinoma of the nasopharynx after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Nasopharyngeal Undifferentiated Carcinoma

Professional guidelines

PubMed

Recurrent/Metastatic Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Heading?
Juarez-Vignon Whaley JJ, Afkhami M, Onyshchenko M, Massarelli E, Sampath S, Amini A, Bell D, Villaflor VM
Curr Treat Options Oncol 2023 Sep;24(9):1138-1166. Epub 2023 Jun 15 doi: 10.1007/s11864-023-01101-3. PMID: 37318724Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng WT, Soong YL, Ahn YC, AlHussain H, Choi HCW, Corry J, Grégoire V, Harrington KJ, Hu CS, Jensen K, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Pan JJ, Peters LJ, Poh SS, Rosenthal DI, Sanguineti G, Tao Y, Wee JT, Yom SS, Chua MLK, Lee AWM
Int J Radiat Oncol Biol Phys 2021 Jul 1;110(3):682-695. Epub 2021 Feb 9 doi: 10.1016/j.ijrobp.2021.01.041. PMID: 33571626
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Nasopharyngeal carcinoma.
Chan AT
Ann Oncol 2010 Oct;21 Suppl 7:vii308-12. doi: 10.1093/annonc/mdq277. PMID: 20943634
Nasopharyngeal carcinoma.
Wei WI, Sham JS
Lancet 2005 Jun 11-17;365(9476):2041-54. doi: 10.1016/S0140-6736(05)66698-6. PMID: 15950718

Diagnosis

Immunotherapy for nasopharyngeal carcinoma: Current status and prospects (Review).
Huang H, Yao Y, Deng X, Huang Z, Chen Y, Wang Z, Hong H, Huang H, Lin T
Int J Oncol 2023 Aug;63(2) Epub 2023 Jul 7 doi: 10.3892/ijo.2023.5545. PMID: 37417358Free PMC Article
Immunotherapeutic approaches in EBV-associated nasopharyngeal carcinoma.
Li W, Duan X, Chen X, Zhan M, Peng H, Meng Y, Li X, Li XY, Pang G, Dou X
Front Immunol 2022;13:1079515. Epub 2023 Jan 11 doi: 10.3389/fimmu.2022.1079515. PMID: 36713430Free PMC Article
Chemotherapy and chemo-resistance in nasopharyngeal carcinoma.
Guan S, Wei J, Huang L, Wu L
Eur J Med Chem 2020 Dec 1;207:112758. Epub 2020 Aug 20 doi: 10.1016/j.ejmech.2020.112758. PMID: 32858472
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Therapy

Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma: The JUPITER-02 Randomized Clinical Trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi Y, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Wang S, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Luo X, Wang X, Tang X, Feng H, Yao S, Keegan P, Xu RH
JAMA 2023 Nov 28;330(20):1961-1970. doi: 10.1001/jama.2023.20181. PMID: 38015220Free PMC Article
Immunotherapy for nasopharyngeal carcinoma: Current status and prospects (Review).
Huang H, Yao Y, Deng X, Huang Z, Chen Y, Wang Z, Hong H, Huang H, Lin T
Int J Oncol 2023 Aug;63(2) Epub 2023 Jul 7 doi: 10.3892/ijo.2023.5545. PMID: 37417358Free PMC Article
Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Prognosis

International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng WT, Soong YL, Ahn YC, AlHussain H, Choi HCW, Corry J, Grégoire V, Harrington KJ, Hu CS, Jensen K, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Pan JJ, Peters LJ, Poh SS, Rosenthal DI, Sanguineti G, Tao Y, Wee JT, Yom SS, Chua MLK, Lee AWM
Int J Radiat Oncol Biol Phys 2021 Jul 1;110(3):682-695. Epub 2021 Feb 9 doi: 10.1016/j.ijrobp.2021.01.041. PMID: 33571626
Salvage Endoscopic Nasopharyngectomy in Recurrent Nasopharyngeal Carcinoma: Prognostic Factors and Treatment Outcomes.
Li W, Lu H, Wang H, Zhang H, Sun X, Hu L, Zhao W, Gu Y, Li H, Wang D
Am J Rhinol Allergy 2021 Jul;35(4):458-466. Epub 2020 Oct 5 doi: 10.1177/1945892420964054. PMID: 33019819
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).
Ma BBY, Lim WT, Goh BC, Hui EP, Lo KW, Pettinger A, Foster NR, Riess JW, Agulnik M, Chang AYC, Chopra A, Kish JA, Chung CH, Adkins DR, Cullen KJ, Gitlitz BJ, Lim DW, To KF, Chan KCA, Lo YMD, King AD, Erlichman C, Yin J, Costello BA, Chan ATC
J Clin Oncol 2018 May 10;36(14):1412-1418. Epub 2018 Mar 27 doi: 10.1200/JCO.2017.77.0388. PMID: 29584545Free PMC Article
Nasopharyngeal carcinoma.
Al-Sarraf M, Reddy MS
Curr Treat Options Oncol 2002 Feb;3(1):21-32. doi: 10.1007/s11864-002-0038-8. PMID: 12057084

Clinical prediction guides

Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma.
Lim DW, Kao HF, Suteja L, Li CH, Quah HS, Tan DS, Tan SH, Tan EH, Tan WL, Lee JN, Wee FY, Jain A, Goh BC, Chua MLK, Liao BC, Ng QS, Hong RL, Ang MK, Yeong JP, Iyer NG
Nat Commun 2023 May 15;14(1):2781. doi: 10.1038/s41467-023-38407-7. PMID: 37188668Free PMC Article
Gemcitabine combined with apatinib and toripalimab in recurrent or metastatic nasopharyngeal carcinoma.
You R, Zou X, Ding X, Zhang WJ, Zhang MX, Wang X, Xu HS, Liu YL, Ouyang YF, Duan CY, Gu CM, Wang ZQ, Liu YP, Hua YJ, Huang PY, Chen MY
Med 2022 Oct 14;3(10):664-681.e6. Epub 2022 Aug 29 doi: 10.1016/j.medj.2022.07.009. PMID: 36041429
Maintenance metronomic chemotherapy for metastatic/recurrent nasopharyngeal carcinoma.
Twu CW, Lin PJ, Tsou HH, Liu YC, Jiang RS, Liang KL, Lin TY, Wang WY, Lin JC
Head Neck 2022 Jun;44(6):1453-1461. Epub 2022 Apr 1 doi: 10.1002/hed.27044. PMID: 35362634
Head and neck cancer: Current challenges and future perspectives.
Bhat GR, Hyole RG, Li J
Adv Cancer Res 2021;152:67-102. Epub 2021 Jun 16 doi: 10.1016/bs.acr.2021.05.002. PMID: 34353444
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article

Recent systematic reviews

Salvage treatments for locally recurrent nasopharyngeal cancer: Systematic review and meta-analysis.
Wang D, Liao M, Wu J, Luo W, Qi S, Liu B, Li J
Head Neck 2023 Feb;45(2):503-520. Epub 2022 Nov 24 doi: 10.1002/hed.27253. PMID: 36420965
Induction chemotherapy in nasopharyngeal carcinoma- A systematic review of phase III clinical trials.
Nazeer F, Poulose JV, Kainickal CT
Cancer Treat Res Commun 2022;32:100589. Epub 2022 Jun 12 doi: 10.1016/j.ctarc.2022.100589. PMID: 35724627
International Guideline on Dose Prioritization and Acceptance Criteria in Radiation Therapy Planning for Nasopharyngeal Carcinoma.
Lee AW, Ng WT, Pan JJ, Chiang CL, Poh SS, Choi HC, Ahn YC, AlHussain H, Corry J, Grau C, Grégoire V, Harrington KJ, Hu CS, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Peters LJ, Rosenthal DI, Sanguineti G, Soong YL, Tao Y, Yom SS, Wee JT
Int J Radiat Oncol Biol Phys 2019 Nov 1;105(3):567-580. Epub 2019 Jul 2 doi: 10.1016/j.ijrobp.2019.06.2540. PMID: 31276776
Systemic therapies for recurrent or metastatic nasopharyngeal carcinoma: a systematic review.
Prawira A, Oosting SF, Chen TW, Delos Santos KA, Saluja R, Wang L, Siu LL, Chan KKW, Hansen AR
Br J Cancer 2017 Dec 5;117(12):1743-1752. Epub 2017 Oct 24 doi: 10.1038/bjc.2017.357. PMID: 29065104Free PMC Article
Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: A systematic review and meta-analysis.
Su L, Zhang M, Zhang W, Cai C, Hong J
Medicine (Baltimore) 2017 Mar;96(11):e6364. doi: 10.1097/MD.0000000000006364. PMID: 28296774Free PMC Article

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