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Recurrent Oropharyngeal Squamous Cell Carcinoma

MedGen UID:
79109
•Concept ID:
C0280376
•
Neoplastic Process
Synonyms: Recurrent Epidermoid Carcinoma of Oropharynx; Recurrent Epidermoid Carcinoma of the Oropharynx; Recurrent Oropharyngeal Epidermoid Carcinoma; Recurrent Oropharyngeal SCC; Recurrent SCC of Oropharynx; Recurrent SCC of the Oropharynx; Recurrent Squamous Cell Carcinoma of Oropharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Relapsed Epidermoid Carcinoma of Oropharynx; Relapsed Epidermoid Carcinoma of the Oropharynx; Relapsed Oropharyngeal Epidermoid Carcinoma; Relapsed Oropharyngeal SCC; Relapsed Oropharyngeal Squamous Cell Carcinoma; Relapsed SCC of Oropharynx; Relapsed SCC of the Oropharynx; Relapsed Squamous Cell Carcinoma of Oropharynx; Relapsed Squamous Cell Carcinoma of the Oropharynx

Definition

Reemergence of squamous cell carcinoma of the oropharynx after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Oropharyngeal Squamous Cell Carcinoma

Professional guidelines

PubMed

Salvage treatment for recurrent oropharyngeal squamous cell carcinoma.
Röösli C, Studer G, Stoeckli SJ
Head Neck 2010 Aug;32(8):989-96. doi: 10.1002/hed.21273. PMID: 19953618

Recent clinical studies

Etiology

Extratumoral invasion: A unique phenomenon of aggressive recurrent oropharyngeal squamous cell carcinoma.
Seo GT, Greenberg L, Xing MH, Su V, Dowling E, Mundi N, Matloob A, Khorsandi AS, Chai RL, Urken ML, Brandwein-Weber M
Am J Otolaryngol 2023 Mar-Apr;44(2):103756. Epub 2022 Dec 27 doi: 10.1016/j.amjoto.2022.103756. PMID: 36603379
Clinicopathologic characteristics and outcomes of recurrent oropharyngeal squamous cell carcinoma.
Heaton CM, Yu K, Calkins S, George JR, Ryan WR, Wang SJ
Am J Otolaryngol 2016 Nov-Dec;37(6):513-516. Epub 2016 Jul 27 doi: 10.1016/j.amjoto.2016.07.007. PMID: 27522438
Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma.
Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano JA, Ha PK, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C
Head Neck 2016 Apr;38 Suppl 1:E1501-9. Epub 2015 Nov 11 doi: 10.1002/hed.24268. PMID: 26558328
Salvage surgery for recurrent oropharyngeal cancer: post-operative oncologic and functional outcomes.
Culié D, Benezery K, Chamorey E, Ettaiche M, Fernandez J, Poissonnet G, Riss JC, Hannoun-Lévi JM, Chand ME, Leysalle A, Saada E, Sudaka A, Haudebourg J, Demard F, Santini J, Peyrade F, Dassonville O, Bozec A
Acta Otolaryngol 2015;135(12):1323-9. Epub 2015 Jul 29 doi: 10.3109/00016489.2015.1066935. PMID: 26223741
Salvage treatment for recurrent oropharyngeal squamous cell carcinoma.
Röösli C, Studer G, Stoeckli SJ
Head Neck 2010 Aug;32(8):989-96. doi: 10.1002/hed.21273. PMID: 19953618

Diagnosis

Association of HPV status with survival after surgical salvage of oropharyngeal cancers.
Patel TR, Lee S, Tajudeen BA, Stenson K, Bhayani M, Al-Khudari S
Am J Otolaryngol 2022 Jul-Aug;43(4):103491. Epub 2022 May 4 doi: 10.1016/j.amjoto.2022.103491. PMID: 35567838
Clinicopathologic characteristics and outcomes of recurrent oropharyngeal squamous cell carcinoma.
Heaton CM, Yu K, Calkins S, George JR, Ryan WR, Wang SJ
Am J Otolaryngol 2016 Nov-Dec;37(6):513-516. Epub 2016 Jul 27 doi: 10.1016/j.amjoto.2016.07.007. PMID: 27522438
Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma.
Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano JA, Ha PK, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C
Head Neck 2016 Apr;38 Suppl 1:E1501-9. Epub 2015 Nov 11 doi: 10.1002/hed.24268. PMID: 26558328
Salvage surgery for recurrent oropharyngeal cancer: post-operative oncologic and functional outcomes.
Culié D, Benezery K, Chamorey E, Ettaiche M, Fernandez J, Poissonnet G, Riss JC, Hannoun-Lévi JM, Chand ME, Leysalle A, Saada E, Sudaka A, Haudebourg J, Demard F, Santini J, Peyrade F, Dassonville O, Bozec A
Acta Otolaryngol 2015;135(12):1323-9. Epub 2015 Jul 29 doi: 10.3109/00016489.2015.1066935. PMID: 26223741
Amoebic abscess diagnosed on fluorodeoxyglucose positron emission tomography scan in patient with recurrent oropharyngeal squamous cell carcinoma.
Cacheux W, Servois V, Paulmier B, Girodet J, Farkhondeh F, Petras S
J Clin Oncol 2011 May 1;29(13):e365-6. Epub 2011 Feb 7 doi: 10.1200/JCO.2010.33.3237. PMID: 21300927

Therapy

Anti-PDL1 Immunotherapy as a Radiosensitizer on Treating Advanced Recurrent Oropharyngeal Squamous Cell Carcinoma.
Pan YA, Su NW, Leu YS
Ear Nose Throat J 2021 Sep;100(5_suppl):415S-416S. Epub 2019 Nov 6 doi: 10.1177/0145561319881565. PMID: 31690109

Prognosis

Extratumoral invasion: A unique phenomenon of aggressive recurrent oropharyngeal squamous cell carcinoma.
Seo GT, Greenberg L, Xing MH, Su V, Dowling E, Mundi N, Matloob A, Khorsandi AS, Chai RL, Urken ML, Brandwein-Weber M
Am J Otolaryngol 2023 Mar-Apr;44(2):103756. Epub 2022 Dec 27 doi: 10.1016/j.amjoto.2022.103756. PMID: 36603379
Clinicopathologic characteristics and outcomes of recurrent oropharyngeal squamous cell carcinoma.
Heaton CM, Yu K, Calkins S, George JR, Ryan WR, Wang SJ
Am J Otolaryngol 2016 Nov-Dec;37(6):513-516. Epub 2016 Jul 27 doi: 10.1016/j.amjoto.2016.07.007. PMID: 27522438
Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma.
Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano JA, Ha PK, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C
Head Neck 2016 Apr;38 Suppl 1:E1501-9. Epub 2015 Nov 11 doi: 10.1002/hed.24268. PMID: 26558328
Salvage surgery for recurrent oropharyngeal cancer: post-operative oncologic and functional outcomes.
Culié D, Benezery K, Chamorey E, Ettaiche M, Fernandez J, Poissonnet G, Riss JC, Hannoun-Lévi JM, Chand ME, Leysalle A, Saada E, Sudaka A, Haudebourg J, Demard F, Santini J, Peyrade F, Dassonville O, Bozec A
Acta Otolaryngol 2015;135(12):1323-9. Epub 2015 Jul 29 doi: 10.3109/00016489.2015.1066935. PMID: 26223741
Salvage treatment for recurrent oropharyngeal squamous cell carcinoma.
Röösli C, Studer G, Stoeckli SJ
Head Neck 2010 Aug;32(8):989-96. doi: 10.1002/hed.21273. PMID: 19953618

Clinical prediction guides

Clinicopathologic characteristics and outcomes of recurrent oropharyngeal squamous cell carcinoma.
Heaton CM, Yu K, Calkins S, George JR, Ryan WR, Wang SJ
Am J Otolaryngol 2016 Nov-Dec;37(6):513-516. Epub 2016 Jul 27 doi: 10.1016/j.amjoto.2016.07.007. PMID: 27522438
Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma.
Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano JA, Ha PK, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C
Head Neck 2016 Apr;38 Suppl 1:E1501-9. Epub 2015 Nov 11 doi: 10.1002/hed.24268. PMID: 26558328
Salvage surgery for recurrent oropharyngeal cancer: post-operative oncologic and functional outcomes.
Culié D, Benezery K, Chamorey E, Ettaiche M, Fernandez J, Poissonnet G, Riss JC, Hannoun-Lévi JM, Chand ME, Leysalle A, Saada E, Sudaka A, Haudebourg J, Demard F, Santini J, Peyrade F, Dassonville O, Bozec A
Acta Otolaryngol 2015;135(12):1323-9. Epub 2015 Jul 29 doi: 10.3109/00016489.2015.1066935. PMID: 26223741

Recent systematic reviews

Survival outcomes following salvage surgery for oropharyngeal squamous cell carcinoma: systematic review.
Kao SS, Ooi EH
J Laryngol Otol 2018 Apr;132(4):299-313. Epub 2017 May 15 doi: 10.1017/S0022215117000998. PMID: 28502256

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