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| Status |
Public on Jul 29, 2016 |
| Title |
Smooth muscle cell mineralocorticoid receptor regulation of vascular microRNAs with aging |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
We used a smooth muscle cell-specific mineralocorticoid receptor knockout mouse to generate young and aged MR-intact and SMC-MR-KO aortic miRNA to examine the effect of age on vascular miRNA alterations in the presence and absence of SMC-MR.
For more information about the mouse model see: McCurley, A et al. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 2012 Sep;18(9):1429-33
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| Overall design |
Total miRNA was extracted from young (3-4 mo) and aged male (12mo) MR-intact and SMC-MR-KO mice to investigate aging-induced alterations in vascular miRNA expression
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| Contributor(s) |
Jaffe IZ, DuPont JJ |
| Citation(s) |
27683672 |
| Submission date |
Jul 28, 2016 |
| Last update date |
May 02, 2017 |
| Contact name |
Iris Jaffe |
| E-mail(s) |
ijaffe@tuftsmedicalcenter.org
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| Organization name |
Tufts Medical Center
|
| Street address |
800 Washington Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02111 |
| Country |
USA |
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| Platforms (1) |
| GPL14613 |
[miRNA-2] Affymetrix Multispecies miRNA-2 Array |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA335749 |
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