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| Status |
Public on Sep 02, 2015 |
| Title |
Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
|
| Summary |
The aim of this study was to characterise the genome-wide DNA methylation profile of osteoathritis (OA) chondrocytes from both knee and hip cartilage, providing the first comparison of DNA methylation between OA and non-OA hip cartilage, and between OA hip and OA knee cartilage. The study was performed using the Illumina Infinium HumanMethylation450 BeadChip array. Genome-wide methylation was assesed in chondrocyte DNA extracted from 23 OA hip, 73 OA knee and 21 healthy hip controls (NOF - neck of femure samples).
Keywords: Methylation profiling by array
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| |
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| Overall design |
Bisulphite converted DNA from the 97 samples were hybridised to the Illumina Infinium HumanMethylation450 BeadChip array.
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| |
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| Contributor(s) |
Skelton AJ, Reynard LN, Loughlin J, Rushton MD |
| Citation(s) |
24838673 |
| Submission date |
Sep 01, 2015 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Andrew James Skelton |
| E-mail(s) |
andrew.skelton@ncl.ac.uk
|
| Organization name |
Newcastle University
|
| Department |
Bioinformatics
|
| Lab |
Musculoskeletal Research Group
|
| Street address |
Framlington Place
|
| City |
Newcastle upon Tyne |
| State/province |
Tyne and Wear |
| ZIP/Postal code |
NE2 4HH |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (97)
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| Relations |
| BioProject |
PRJNA294636 |
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