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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 04, 2013 |
| Title |
NLRP7 promotes trophoblast lineage differentiation, YY1 binding and alters CpG methylation |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
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| Summary |
Genome wide DNA methylation profiling of hESC in the untransduced, scrambled control and with knockdown of NLRP7 in undifferentiated and BMP4 differentiated states using the Illumina HumanMethylation 450 BeadChip. Several genomic sites exhibit altered methylation upon knocking down NLRP7.
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| Overall design |
Bisulphite converted DNA from 3 replicates of untransduced, scrambled control and NLRP7 knockdown in the undifferentiated and BMP differentiated groups were hybridised to the Illumina Human Methylation 450 Beadchip.
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| Contributor(s) |
Mahadevan S, Wen S, Wan Y, Peng H, Otta S, Liu Z, Iacovino M, Mahen EM, Kyba M, Sadikovic B, Van den Veyver IB |
| Citation(s) |
24105472 |
| Submission date |
Apr 03, 2013 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Sangeetha Kaveri Mahadevan |
| Organization name |
Baylor College of Medicine
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| Department |
Obsterics and Gynecology
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| Lab |
Ignatia Van den Veyver
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| Street address |
1250 Moursund St, Room 1025
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| City |
Houston |
| State/province |
Texas |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (18)
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| GSM1113249 |
genomic DNA from undifferentiated, untransduced H9 hESC, replicate A |
| GSM1113250 |
genomic DNA from undifferentiated, scrambled H9 hESC, replicate A |
| GSM1113251 |
genomic DNA from undifferentiated, NLRP7 knockdown H9 hESC, replicate A |
| GSM1113252 |
genomic DNA from differentiated, untransduced H9 hESC, replicate A |
| GSM1113253 |
genomic DNA from differentiated, scrambled H9 hESC, replicate A |
| GSM1113254 |
genomic DNA from differentiated, NLRP7 knockdown H9 hESC, replicate A |
| GSM1113255 |
genomic DNA from undifferentiated, untransduced H9 hESC, replicate B |
| GSM1113256 |
genomic DNA from undifferentiated, scrambled H9 hESC, replicate B |
| GSM1113257 |
genomic DNA from undifferentiated, NLRP7 knockdown H9 hESC, replicate B |
| GSM1113258 |
genomic DNA from differentiated, untransduced H9 hESC, replicate B |
| GSM1113259 |
genomic DNA from differentiated, scrambled H9 hESC, replicate B |
| GSM1113260 |
genomic DNA from differentiated, NLRP7 knockdown H9 hESC, replicate B |
| GSM1113261 |
genomic DNA from undifferentiated, untransduced H9 hESC, replicate C |
| GSM1113262 |
genomic DNA from undifferentiated, scrambled H9 hESC, replicate C |
| GSM1113263 |
genomic DNA from undifferentiated, NLRP7 knockdown H9 hESC, replicate C |
| GSM1113264 |
genomic DNA from differentiated, untransduced H9 hESC, replicate C |
| GSM1113265 |
genomic DNA from differentiated, scrambled H9 hESC, replicate C |
| GSM1113266 |
genomic DNA from differentiated, NLRP7 knockdown H9 hESC, replicate C |
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| Relations |
| BioProject |
PRJNA196136 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE45727_RAW.tar |
183.1 Mb |
(http)(custom) |
TAR |
| GSE45727_non_normalized_array1.txt.gz |
19.5 Mb |
(ftp)(http) |
TXT |
| GSE45727_non_normalized_array2.txt.gz |
33.1 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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