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    Mettl6 methyltransferase 6, methylcytidine [ Mus musculus (house mouse) ]

    Gene ID: 67011, updated on 7-May-2024

    Summary

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    Official Symbol
    Mettl6provided by MGI
    Official Full Name
    methyltransferase 6, methylcytidineprovided by MGI
    Primary source
    MGI:MGI:1914261
    See related
    Ensembl:ENSMUSG00000021891 AllianceGenome:MGI:1914261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1600013P15Rik
    Summary
    Enables tRNA (cytosine-3-)-methyltransferase activity. Involved in tRNA methylation. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human METTL6 (methyltransferase 6, methylcytidine). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.3), CNS E11.5 (RPKM 4.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 B; 14 19.12 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31180775..31217007, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31463715..31495059, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32149566-32149675 Neighboring gene calpain 7 Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene STARR-seq mESC enhancer starr_36314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:32229701-32230002 Neighboring gene predicted gene, 35907 Neighboring gene STARR-positive B cell enhancer ABC_E7303 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36316 Neighboring gene ELL associated factor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32345029-32345265 Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32369012-32369287 Neighboring gene STARR-seq mESC enhancer starr_36317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth. Ignatova VV, et al. Sci Adv, 2020 Aug. PMID 32923617, Free PMC Article
    2. Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. Xu L, et al. J Biol Chem, 2017 Sep 1. PMID 28655767, Free PMC Article
    3. Loss of maternal Trim28 causes male-predominant early embryonic lethality. Sampath Kumar A, et al. Genes Dev, 2017 Jan 1. PMID 28115466, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine-3-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA (cytidine-3-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA N(3)-methylcytidine methyltransferase METTL6
    Names
    methyltransferase like 6
    methyltransferase-like protein 6
    NP_001346775.1
    NP_001346776.1
    NP_001346777.1
    NP_001346778.1
    NP_001346779.1
    NP_001361702.1
    NP_080183.1
    XP_011243456.1
    XP_030103822.1
    XP_030103823.1
    XP_030103824.1
    XP_030103826.1
    XP_030103828.1
    XP_036014717.1
    XP_036014718.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359846.1 → NP_001346775.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AV241644
      Consensus CDS
      CCDS26913.1
      UniProtKB/Swiss-Prot
      Q8BVH9, Q9D9M6, Q9DAX6
      Conserved Domains (1) summary
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain

    2. NM_001359847.1 → NP_001346776.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK133735
      Consensus CDS
      CCDS88619.1
      UniProtKB/TrEMBL
      A0A2I3BRX7
      Related
      ENSMUSP00000154767.2, ENSMUST00000227777.2
      Conserved Domains (1) summary
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain

    3. NM_001359848.1 → NP_001346777.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AK006715, AV241644
      Consensus CDS
      CCDS88617.1
      Related
      ENSMUSP00000154580.2, ENSMUST00000227595.2
      Conserved Domains (1) summary
      pfam13649
      Location:70 → 137
      Methyltransf_25; Methyltransferase domain

    4. NM_001359849.1 → NP_001346778.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AV241644
      UniProtKB/TrEMBL
      A0A2I3BQ54
      Related
      ENSMUSP00000153931.2, ENSMUST00000228181.2
      Conserved Domains (2) summary
      COG2227
      Location:29 → 124
      UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
      pfam08242
      Location:84 → 177
      Methyltransf_12; Methyltransferase domain

    5. NM_001359850.1 → NP_001346779.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AV241644
      Conserved Domains (1) summary
      pfam08242
      Location:133 → 231
      Methyltransf_12; Methyltransferase domain

    6. NM_001374773.1 → NP_001361702.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK078185
      Consensus CDS
      CCDS88618.1
      Related
      ENSMUSP00000154679.2, ENSMUST00000228727.2
      Conserved Domains (1) summary
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain

    7. NM_025907.4 → NP_080183.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 1

      See identical proteins and their annotated locations for NP_080183.1

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AV241644
      Consensus CDS
      CCDS26913.1
      UniProtKB/Swiss-Prot
      Q8BVH9, Q9D9M6, Q9DAX6
      Related
      ENSMUSP00000077138.3, ENSMUST00000055303.5
      Conserved Domains (1) summary
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31180775..31217007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247966.2 → XP_030103826.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X5

      Conserved Domains (1) summary
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain

    2. XM_030247968.2 → XP_030103828.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X6

      Conserved Domains (1) summary
      pfam13649
      Location:70 → 137
      Methyltransf_25; Methyltransferase domain

    3. XM_030247962.2 → XP_030103822.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X2

      Conserved Domains (1) summary
      pfam08242
      Location:133 → 231
      Methyltransf_12; Methyltransferase domain

    4. XM_036158825.1 → XP_036014718.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X7

      Conserved Domains (1) summary
      cl17173
      Location:76 → 132
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_036158824.1 → XP_036014717.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X1

      Conserved Domains (1) summary
      pfam08242
      Location:134 → 232
      Methyltransf_12; Methyltransferase domain

    6. XM_030247963.2 → XP_030103823.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X3

      Conserved Domains (1) summary
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain

    7. XM_011245154.3 → XP_011243456.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X3

      Conserved Domains (1) summary
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain

    8. XM_030247964.2 → XP_030103824.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X4

      Conserved Domains (1) summary
      pfam08242
      Location:134 → 232
      Methyltransf_12; Methyltransferase domain

    RNA

    1. XR_874361.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVH9.2 GenPept UniProtKB/Swiss-Prot:Q8BVH9

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