NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1331036840|ref|NP_001346778|]
View 

tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 4 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549439)

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.-.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-177 3.72e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


:

Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 67.78  E-value: 3.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  84 LEAGCGVGNCLFPLLEEDLNLFAYACDFSPRAVDYVKQH----PLYNAERCKVFQCDLTRDDlldhvpPESVDAVTLIFV 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaalGLLNAVRVELFQLDLGELD------PGSFDVVVASNV 74

                          90
                  ....*....|....*...
gi 1331036840 160 LSavHPEKMRLVLLNVYK 177
Cdd:pfam08242  75 LH--HLADPRAVLRNIRR 90
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-177 3.72e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 67.78  E-value: 3.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  84 LEAGCGVGNCLFPLLEEDLNLFAYACDFSPRAVDYVKQH----PLYNAERCKVFQCDLTRDDlldhvpPESVDAVTLIFV 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaalGLLNAVRVELFQLDLGELD------PGSFDVVVASNV 74

                          90
                  ....*....|....*...
gi 1331036840 160 LSavHPEKMRLVLLNVYK 177
Cdd:pfam08242  75 LH--HLADPRAVLRNIRR 90
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 82-171 1.99e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.82  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  82 TLLEAGCGVGNCLFPLLeEDLNLFAYACDFSPRAVDYVKQ-HPLYNAERCKVFQCDLTRddlLDHVPPESVDAVTLIFVL 160
Cdd:cd02440     1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKaAAALLADNVEVLKGDAEE---LPPEADESFDVIISDPPL 76

                          90
                  ....*....|.
gi 1331036840 161 SAVHPEKMRLV 171
Cdd:cd02440    77 HHLVEDLARFL 87
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 54-160 6.60e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 51.94  E-value: 6.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  54 TNFFKDRHWTTReFEELrsCREYEGQKLTLLEAGCGVGNCLFPLLEEDLNlfAYACDFSPRAVDYVKQHplYNAERCKVF 133
Cdd:COG2227     2 SDPDARDFWDRR-LAAL--LARLLPAGGRVLDVGCGTGRLALALARRGAD--VTGVDISPEALEIARER--AAELNVDFV 74

                          90       100
                  ....*....|....*....|....*..
gi 1331036840 134 QCDLTRDDLldhvPPESVDAVTLIFVL 160
Cdd:COG2227    75 QGDLEDLPL----EDGSFDLVICSEVL 97
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-177 3.72e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 67.78  E-value: 3.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  84 LEAGCGVGNCLFPLLEEDLNLFAYACDFSPRAVDYVKQH----PLYNAERCKVFQCDLTRDDlldhvpPESVDAVTLIFV 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaalGLLNAVRVELFQLDLGELD------PGSFDVVVASNV 74

                          90
                  ....*....|....*...
gi 1331036840 160 LSavHPEKMRLVLLNVYK 177
Cdd:pfam08242  75 LH--HLADPRAVLRNIRR 90
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 84-177 1.31e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 61.04  E-value: 1.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  84 LEAGCGVGNCLFPLLEEdLNLFAYACDFSPRAVDYVKQHPLYNAERCKVFQCDLTRDDLLDhvppESVDAVTLIFVLSAV 163
Cdd:pfam13649   2 LDLGCGTGRLTLALARR-GGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPD----GSFDLVVSSGVLHHL 76

                          90
                  ....*....|....
gi 1331036840 164 HPEKMRLVLLNVYK 177
Cdd:pfam13649  77 PDPDLEAALREIAR 90
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 82-171 1.99e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.82  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  82 TLLEAGCGVGNCLFPLLeEDLNLFAYACDFSPRAVDYVKQ-HPLYNAERCKVFQCDLTRddlLDHVPPESVDAVTLIFVL 160
Cdd:cd02440     1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKaAAALLADNVEVLKGDAEE---LPPEADESFDVIISDPPL 76

                          90
                  ....*....|.
gi 1331036840 161 SAVHPEKMRLV 171
Cdd:cd02440    77 HHLVEDLARFL 87
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 54-160 6.60e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 51.94  E-value: 6.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  54 TNFFKDRHWTTReFEELrsCREYEGQKLTLLEAGCGVGNCLFPLLEEDLNlfAYACDFSPRAVDYVKQHplYNAERCKVF 133
Cdd:COG2227     2 SDPDARDFWDRR-LAAL--LARLLPAGGRVLDVGCGTGRLALALARRGAD--VTGVDISPEALEIARER--AAELNVDFV 74

                          90       100
                  ....*....|....*....|....*..
gi 1331036840 134 QCDLTRDDLldhvPPESVDAVTLIFVL 160
Cdd:COG2227    75 QGDLEDLPL----EDGSFDLVICSEVL 97
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 82-168 1.87e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 48.07  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  82 TLLEAGCGVGNCLFPLLEEDLNLfaYACDFSPRAVDYVKQHPLYNAERCKVFQCDLTRDDLldhvPPESVDAVTLIFVLS 161
Cdd:COG2226    25 RVLDLGCGTGRLALALAERGARV--TGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPF----PDGSFDLVISSFVLH 98


                  ....*...
gi 1331036840 162 AV-HPEKM 168
Cdd:COG2226    99 HLpDPERA 106
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
81-177 6.54e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 44.60  E-value: 6.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  81 LTLLEAGCGVGNCLFPLLEEDLNLfaYACDFSPRAVDYVKQHPLYNAerckVFQCDLTRDDlldhVPPESVDAVTLIFVL 160
Cdd:COG4976    48 GRVLDLGCGTGLLGEALRPRGYRL--TGVDLSEEMLAKAREKGVYDR----LLVADLADLA----EPDGRFDLIVAADVL 117

                          90
                  ....*....|....*..
gi 1331036840 161 SavHPEKMRLVLLNVYK 177
Cdd:COG4976   118 T--YLGDLAAVFAGVAR 132
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-160 1.06e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 42.27  E-value: 1.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1331036840  84 LEAGCGVGNCLFPLLEedLNLFAYACDFSPRAVDYVKQHplYNAERCKVFQCDLTRDDLLDhvppESVDAVTLIFVL 160
Cdd:pfam08241   1 LDVGCGTGLLTELLAR--LGARVTGVDISPEMLELAREK--APREGLTFVVGDAEDLPFPD----NSFDLVLSSEVL 69
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 82-172 6.52e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.37  E-value: 6.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331036840  82 TLLEAGCGVGNCLFPLLEEdLNLFAYACDFSPRAVDYVKQ----HPLynAERCKVFQCDLTrddllDHVPPESVDAVTLI 157
Cdd:COG2230    54 RVLDIGCGWGGLALYLARR-YGVRVTGVTLSPEQLEYAREraaeAGL--ADRVEVRLADYR-----DLPADGQFDAIVSI 125

                          90
                  ....*....|....*
gi 1331036840 158 FVLSAVHPEKMRLVL 172
Cdd:COG2230   126 GMFEHVGPENYPAYF 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH