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Conserved domains on  [gi|1907104995|ref|XP_036014718|]
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tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X7 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 76-132 7.74e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam08242:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 98  Bit Score: 33.88  E-value: 7.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907104995  76 QHPLYNAERCKVFQCDLTRDDlldhvpPESVDAVTLIFVLSavHPEKMRLVLLNVYK 132
Cdd:pfam08242  42 ALGLLNAVRVELFQLDLGELD------PGSFDVVVASNVLH--HLADPRAVLRNIRR 90
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 76-132 7.74e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 33.88  E-value: 7.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907104995  76 QHPLYNAERCKVFQCDLTRDDlldhvpPESVDAVTLIFVLSavHPEKMRLVLLNVYK 132
Cdd:pfam08242  42 ALGLLNAVRVELFQLDLGELD------PGSFDVVVASNVLH--HLADPRAVLRNIRR 90
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 76-132 7.74e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 33.88  E-value: 7.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907104995  76 QHPLYNAERCKVFQCDLTRDDlldhvpPESVDAVTLIFVLSavHPEKMRLVLLNVYK 132
Cdd:pfam08242  42 ALGLLNAVRVELFQLDLGELD------PGSFDVVVASNVLH--HLADPRAVLRNIRR 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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