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Conserved domains on  [gi|1720380507|ref|XP_030103826|]
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tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X5 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549439)

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.-.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-182 1.29e-17

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


:

Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 75.10  E-value: 1.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  84 LEAGCGVGNCLFPLLEEDLNLFAYACDFSPRAVDYVKQH----PLYNAERCKVFQCDLTRDDlldhvpPESVDAVTLIFV 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaalGLLNAVRVELFQLDLGELD------PGSFDVVVASNV 74

                          90       100
                  ....*....|....*....|...
gi 1720380507 160 LSavHPEKMRLVLLNVYKVLKPG 182
Cdd:pfam08242  75 LH--HLADPRAVLRNIRRLLKPG 95
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-182 1.29e-17

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 75.10  E-value: 1.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  84 LEAGCGVGNCLFPLLEEDLNLFAYACDFSPRAVDYVKQH----PLYNAERCKVFQCDLTRDDlldhvpPESVDAVTLIFV 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaalGLLNAVRVELFQLDLGELD------PGSFDVVVASNV 74

                          90       100
                  ....*....|....*....|...
gi 1720380507 160 LSavHPEKMRLVLLNVYKVLKPG 182
Cdd:pfam08242  75 LH--HLADPRAVLRNIRRLLKPG 95
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 82-187 7.86e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.45  E-value: 7.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  82 TLLEAGCGVGNCLFPLLeEDLNLFAYACDFSPRAVDYVKQ-HPLYNAERCKVFQCDLTRddlLDHVPPESVDAVTLIFVL 160
Cdd:cd02440     1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKaAAALLADNVEVLKGDAEE---LPPEADESFDVIISDPPL 76

                          90       100
                  ....*....|....*....|....*..
gi 1720380507 161 SAVHPEKMRlVLLNVYKVLKPGRSVLF 187
Cdd:cd02440    77 HHLVEDLAR-FLEEARRLLKPGGVLVL 102
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 54-190 2.74e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 61.57  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  54 TNFFKDRHWTTREFEELRscrEYEGQKLTLLEAGCGVGNCLFPLLEEDLNlfAYACDFSPRAVDYVKQHplYNAERCKVF 133
Cdd:COG2227     2 SDPDARDFWDRRLAALLA---RLLPAGGRVLDVGCGTGRLALALARRGAD--VTGVDISPEALEIARER--AAELNVDFV 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720380507 134 QCDLTRDDLldhvPPESVDAVTLIFVLSavHPEKMRLVLLNVYKVLKPGRSVLFRDY 190
Cdd:COG2227    75 QGDLEDLPL----EDGSFDLVICSEVLE--HLPDPAALLRELARLLKPGGLLLLSTP 125
PRK06202 PRK06202
hypothetical protein; Provisional
 77-219 7.64e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 39.60  E-value: 7.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  77 EGQKLTLLEAGCGVGNCLFPLL----EEDLNLFAYACDFSPRAVDYVKQHPLYNAERCKVFqcdlTRDDLLDHvpPESVD 152
Cdd:PRK06202   58 ADRPLTLLDIGCGGGDLAIDLArwarRDGLRLEVTAIDPDPRAVAFARANPRRPGVTFRQA----VSDELVAE--GERFD 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720380507 153 AVTLIFVLSAVHPEKMRlVLLNVYKVLKPgRSVLFRDYGLNDHAMLRFKAGSK-LGENFYVRQDGTRS 219
Cdd:PRK06202  132 VVTSNHFLHHLDDAEVV-RLLADSAALAR-RLVLHNDLIRSRLAYALFWAGTRlLSRSSFVHTDGLLS 197
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-182 1.29e-17

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 75.10  E-value: 1.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  84 LEAGCGVGNCLFPLLEEDLNLFAYACDFSPRAVDYVKQH----PLYNAERCKVFQCDLTRDDlldhvpPESVDAVTLIFV 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaalGLLNAVRVELFQLDLGELD------PGSFDVVVASNV 74

                          90       100
                  ....*....|....*....|...
gi 1720380507 160 LSavHPEKMRLVLLNVYKVLKPG 182
Cdd:pfam08242  75 LH--HLADPRAVLRNIRRLLKPG 95
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 84-182 2.42e-17

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 74.14  E-value: 2.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  84 LEAGCGVGNCLFPLLEEdLNLFAYACDFSPRAVDYVKQHPLYNAERCKVFQCDLTRDDLLDhvppESVDAVTLIFVLSAV 163
Cdd:pfam13649   2 LDLGCGTGRLTLALARR-GGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPD----GSFDLVVSSGVLHHL 76

                          90
                  ....*....|....*....
gi 1720380507 164 HPEKMRLVLLNVYKVLKPG 182
Cdd:pfam13649  77 PDPDLEAALREIARVLKPG 95
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 82-187 7.86e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.45  E-value: 7.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  82 TLLEAGCGVGNCLFPLLeEDLNLFAYACDFSPRAVDYVKQ-HPLYNAERCKVFQCDLTRddlLDHVPPESVDAVTLIFVL 160
Cdd:cd02440     1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKaAAALLADNVEVLKGDAEE---LPPEADESFDVIISDPPL 76

                          90       100
                  ....*....|....*....|....*..
gi 1720380507 161 SAVHPEKMRlVLLNVYKVLKPGRSVLF 187
Cdd:cd02440    77 HHLVEDLAR-FLEEARRLLKPGGVLVL 102
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 54-190 2.74e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 61.57  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  54 TNFFKDRHWTTREFEELRscrEYEGQKLTLLEAGCGVGNCLFPLLEEDLNlfAYACDFSPRAVDYVKQHplYNAERCKVF 133
Cdd:COG2227     2 SDPDARDFWDRRLAALLA---RLLPAGGRVLDVGCGTGRLALALARRGAD--VTGVDISPEALEIARER--AAELNVDFV 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720380507 134 QCDLTRDDLldhvPPESVDAVTLIFVLSavHPEKMRLVLLNVYKVLKPGRSVLFRDY 190
Cdd:COG2227    75 QGDLEDLPL----EDGSFDLVICSEVLE--HLPDPAALLRELARLLKPGGLLLLSTP 125
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 82-199 7.01e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 60.78  E-value: 7.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  82 TLLEAGCGVGNCLFPLLEEDLNLfaYACDFSPRAVDYVKQHPLYNAERCKVFQCDLTRDDLldhvPPESVDAVTLIFVLS 161
Cdd:COG2226    25 RVLDLGCGTGRLALALAERGARV--TGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPF----PDGSFDLVISSFVLH 98

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1720380507 162 AV-HPEKmrlVLLNVYKVLKPGRSVLFRDYGLNDHAMLR 199
Cdd:COG2226    99 HLpDPER---ALAEIARVLKPGGRLVVVDFSPPDLAELE 134
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 79-193 5.10e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.85  E-value: 5.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  79 QKLTLLEAGCGVGNCLFPLLEEDLNLFaYACDFSPRAVDYVKQ-HPLYNAERCKVFQCDLTRddlLDHVPPESVDAVTLI 157
Cdd:COG0500    26 KGGRVLDLGCGTGRNLLALAARFGGRV-IGIDLSPEAIALARArAAKAGLGNVEFLVADLAE---LDPLPAESFDLVVAF 101

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1720380507 158 FVLSAVHPEKMRLVLLNVYKVLKPGRSVLFRDYGLN 193
Cdd:COG0500   102 GVLHHLPPEEREALLRELARALKPGGVLLLSASDAA 137
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-182 1.05e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 51.13  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  84 LEAGCGVGNCLFPLLEedLNLFAYACDFSPRAVDYVKQHplYNAERCKVFQCDLTRDDLLDhvppESVDAVTLIFVLSAV 163
Cdd:pfam08241   1 LDVGCGTGLLTELLAR--LGARVTGVDISPEMLELAREK--APREGLTFVVGDAEDLPFPD----NSFDLVLSSEVLHHV 72

                          90       100
                  ....*....|....*....|
gi 1720380507 164 H-PEKmrlVLLNVYKVLKPG 182
Cdd:pfam08241  73 EdPER---ALREIARVLKPG 89
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
81-182 2.77e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.92  E-value: 2.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  81 LTLLEAGCGVGNCLFPLLEEDLNLfaYACDFSPRAVDYVKQHPLYNAerckVFQCDLTRDDlldhVPPESVDAVTLIFVL 160
Cdd:COG4976    48 GRVLDLGCGTGLLGEALRPRGYRL--TGVDLSEEMLAKAREKGVYDR----LLVADLADLA----EPDGRFDLIVAADVL 117

                          90       100
                  ....*....|....*....|..
gi 1720380507 161 SavHPEKMRLVLLNVYKVLKPG 182
Cdd:COG4976   118 T--YLGDLAAVFAGVARALKPG 137
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 82-182 3.84e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.00  E-value: 3.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  82 TLLEAGCGVGNCLFPLLEEdLNLFAYACDFSPRAVDYVKQ----HPLynAERCKVFQCDLTrddllDHVPPESVDAVTLI 157
Cdd:COG2230    54 RVLDIGCGWGGLALYLARR-YGVRVTGVTLSPEQLEYAREraaeAGL--ADRVEVRLADYR-----DLPADGQFDAIVSI 125

                          90       100
                  ....*....|....*....|....*
gi 1720380507 158 FVLSAVHPEKMRLVLLNVYKVLKPG 182
Cdd:COG2230   126 GMFEHVGPENYPAYFAKVARLLKPG 150
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 81-190 2.25e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 40.09  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  81 LTLLEAGCGVGNCLFPLLEEDL-NLFAYACDFSPRAVDYVKQH-PLYNAERCKVFQCDLTrdDLLDHVPPESVDAVTLIF 158
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEELGpNAEVVGIDISEEAIEKARENaQKLGFDNVEFEQGDIE--ELPELLEDDKFDVVISNC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1720380507 159 VLSAV-HPEKmrlVLLNVYKVLKPGRSVLFRDY 190
Cdd:pfam13847  83 VLNHIpDPDK---VLQEILRVLKPGGRLIISDP 112
PRK06202 PRK06202
hypothetical protein; Provisional
 77-219 7.64e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 39.60  E-value: 7.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  77 EGQKLTLLEAGCGVGNCLFPLL----EEDLNLFAYACDFSPRAVDYVKQHPLYNAERCKVFqcdlTRDDLLDHvpPESVD 152
Cdd:PRK06202   58 ADRPLTLLDIGCGGGDLAIDLArwarRDGLRLEVTAIDPDPRAVAFARANPRRPGVTFRQA----VSDELVAE--GERFD 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720380507 153 AVTLIFVLSAVHPEKMRlVLLNVYKVLKPgRSVLFRDYGLNDHAMLRFKAGSK-LGENFYVRQDGTRS 219
Cdd:PRK06202  132 VVTSNHFLHHLDDAEVV-RLLADSAALAR-RLVLHNDLIRSRLAYALFWAGTRlLSRSSFVHTDGLLS 197
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 60-223 9.81e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 35.48  E-value: 9.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507  60 RHWTTREFEELRS-CREYEGQKLTLLEAGCGVGNCLFPLLEEDLNLFAYacDFSPRAVDYVKQHPLYnaercKVFqcdlt 138
Cdd:pfam13489   2 AHQRERLLADLLLrLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGV--DPSPIAIERALLNVRF-----DQF----- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380507 139 rDDLLDHVPPESVDAVTLIFVLSAVHPekMRLVLLNVYKVLKPGRSVLFRDYGLNDHamlrfkAGSKLGENFYVRQDGTR 218
Cdd:pfam13489  70 -DEQEAAVPAGKFDVIVAREVLEHVPD--PPALLRQIAALLKPGGLLLLSTPLASDE------ADRLLLEWPYLRPRNGH 140


                  ....*
gi 1720380507 219 SYFFT 223
Cdd:pfam13489 141 ISLFS 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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