Mid1 midline 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mid1provided by MGI
Official Full Name: midline 1provided by MGI
Primary source: MGI:MGI:1100537
See related: Ensembl:ENSMUSG00000035299 AllianceGenome:MGI:1100537
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fxy; 61B3-R; Trim18; DXHXS1141
Summary: Predicted to enable several functions, including microtubule binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Located in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; genitourinary system; and sensory organ. Used to study Opitz-GBBB syndrome and microphthalmia. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome type I. Orthologous to human MID1 (midline 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.3), cerebellum adult (RPKM 4.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F5; X 79.19 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (168468178..168773692)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (169685199..169990798)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway.
Title: Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway.
Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
Title: Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.
Title: Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.
E3 Ubiquitin Ligase Midline 1 Regulates Endothelial Cell ICAM-1 Expression and Neutrophil Adhesion in Abdominal Sepsis.
Title: E3 Ubiquitin Ligase Midline 1 Regulates Endothelial Cell ICAM-1 Expression and Neutrophil Adhesion in Abdominal Sepsis.
TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Title: TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy.
Title: Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy.
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Title: Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
lncRNA 5430416N02Rik Promotes the Proliferation of Mouse Embryonic Stem Cells by Activating Mid1 Expression through 3D Chromatin Architecture.
Title: lncRNA 5430416N02Rik Promotes the Proliferation of Mouse Embryonic Stem Cells by Activating Mid1 Expression through 3D Chromatin Architecture.
MID1 levels were inversely associated while PP2A activity levels correlated with DLco. Tnfsf10(-/-) and mice treated with the protein phosphatase 2A (PP2A) activator AAL(s) were largely protected against bleomycin-induced reductions in lung function and fibrotic changes. TRAIL signalling through MID1 deactivates PP2A and promotes fibrosis with corresponding lung function decline.
Title: TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis.
Study shows that pharmacological disruption of the MID1/alpha4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.
Title: Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC311143P1 (e-PCR)
- UniSTS:272896

Mid1 (e-PCR), detects polymorphism
- UniSTS:532240

DXCbl1 (e-PCR), detects polymorphism
- UniSTS:142888

DXUsc2 (e-PCR), detects polymorphism
- UniSTS:142926

DXYCbl1 (e-PCR), detects polymorphism
- UniSTS:142929

Mid1 (e-PCR), detects polymorphism
- UniSTS:259695

Mid1 (e-PCR), detects polymorphism
- UniSTS:259696

Mid1 (e-PCR), detects polymorphism
- UniSTS:259697

px-64h6 (e-PCR)
- UniSTS:258447

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in protein localization to microtubule	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Midline-1

Names: RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; midin; tripartite motif-containing protein 18

NP_001277433.1

EC 2.3.2.27

NP_001277434.1

EC 2.3.2.27

NP_001277435.1

EC 2.3.2.27

NP_001277441.1

EC 2.3.2.27

NP_001412811.1

EC 2.3.2.27

NP_001412812.1

EC 2.3.2.27

NP_001412814.1

EC 2.3.2.27

NP_001412815.1

EC 2.3.2.27

NP_034927.2

EC 2.3.2.27

XP_006528799.1

EC 2.3.2.27

XP_006528800.1

EC 2.3.2.27

XP_017173899.1

EC 2.3.2.27

XP_017173900.1

EC 2.3.2.27

XP_017173901.1

EC 2.3.2.27

XP_017173902.1

EC 2.3.2.27

XP_030107101.1

EC 2.3.2.27

XP_030107103.1

EC 2.3.2.27

XP_030107104.1

EC 2.3.2.27

XP_036017723.1

EC 2.3.2.27

XP_036017724.1

EC 2.3.2.27

XP_036017725.1

EC 2.3.2.27

XP_036017726.1

EC 2.3.2.27

XP_036017727.1

EC 2.3.2.27

XP_036017728.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290504.2 → NP_001277433.1 E3 ubiquitin-protein ligase Midline-1 isoform 2

See identical proteins and their annotated locations for NP_001277433.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 3, 4, and 9 all encode the same isoform (2).

Source sequence(s)

AL672015, CR478112

UniProtKB/Swiss-Prot

O70583

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:395 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:485 → 661

SPRY; SPRY domain
NM_001290505.2 → NP_001277434.1 E3 ubiquitin-protein ligase Midline-1 isoform 2

See identical proteins and their annotated locations for NP_001277434.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 3, 4, and 9 all encode the same isoform (2).

Source sequence(s)

AL672015, CR478112

UniProtKB/Swiss-Prot

O70583

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:395 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:485 → 661

SPRY; SPRY domain
NM_001290506.2 → NP_001277435.1 E3 ubiquitin-protein ligase Midline-1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and uses two alternate in-frame splice sites, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AL672015, CR478112

UniProtKB/Swiss-Prot

O70583

Conserved Domains (6) summary

smart00502
Location:182 → 306

BBC; B-Box C-terminal domain

cd00063
Location:357 → 443

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

pfam18568
Location:285 → 336

COS; TRIM C-terminal subgroup One Signature domain

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

cl02614
Location:447 → 623

SPRY; SPRY domain
NM_001290512.2 → NP_001277441.1 E3 ubiquitin-protein ligase Midline-1 isoform 4

See identical proteins and their annotated locations for NP_001277441.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate in-frame splice site, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AL671865, AL672015, CR478112

UniProtKB/TrEMBL

B1AUZ9, Q3TVH5

Related

ENSMUSP00000107735.2, ENSMUST00000112107.8

Conserved Domains (3) summary

cd00063
Location:189 → 275

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl02614
Location:279 → 455

SPRY; SPRY domain

cl23765
Location:17 → 138

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001425882.1 → NP_001412811.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

Status: VALIDATED

Source sequence(s)

AL672015, CR478112

UniProtKB/Swiss-Prot

B1AV00, O35418, O70583, Q7TPT6
NM_001425883.1 → NP_001412812.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

Status: VALIDATED

Source sequence(s)

AL672015, CR478112

UniProtKB/Swiss-Prot

B1AV00, O35418, O70583, Q7TPT6
NM_001425885.1 → NP_001412814.1 E3 ubiquitin-protein ligase Midline-1 isoform 2

Status: VALIDATED

Source sequence(s)

AL671865, AL672015, CR478112
NM_001425886.1 → NP_001412815.1 E3 ubiquitin-protein ligase Midline-1 isoform 5

Status: VALIDATED

Source sequence(s)

AL672015, CR478112
NM_010797.4 → NP_034927.2 E3 ubiquitin-protein ligase Midline-1 isoform 1

See identical proteins and their annotated locations for NP_034927.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 7, and 8 all encode the same isoform (1).

Source sequence(s)

AL671865, AL672015, CR478112

Consensus CDS

CCDS41215.1

UniProtKB/Swiss-Prot

B1AV00, O35418, O70583, Q7TPT6

Related

ENSMUSP00000107732.2, ENSMUST00000112104.8

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:395 → 494

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

cl02614
Location:498 → 674

SPRY; SPRY domain

RNA

NR_189632.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL672015, CR478112

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

168468178..168773692

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161833.1 → XP_036017726.1 E3 ubiquitin-protein ligase Midline-1 isoform X7

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00162
Location:10 → 59

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:383 → 559

SPRY; SPRY domain

cl17238
Location:8 → 61

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_036161832.1 → XP_036017725.1 E3 ubiquitin-protein ligase Midline-1 isoform X7

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00162
Location:10 → 59

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:383 → 559

SPRY; SPRY domain

cl17238
Location:8 → 61

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_030251243.2 → XP_030107103.1 E3 ubiquitin-protein ligase Midline-1 isoform X5

Conserved Domains (8) summary

smart00502
Location:191 → 308

BBC; B-Box C-terminal domain

cd00063
Location:359 → 445

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00162
Location:10 → 59

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam18568
Location:287 → 338

COS; TRIM C-terminal subgroup One Signature domain

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

cl02614
Location:449 → 625

SPRY; SPRY domain

cl17238
Location:8 → 61

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_030251244.2 → XP_030107104.1 E3 ubiquitin-protein ligase Midline-1 isoform X6

Conserved Domains (6) summary

smart00502
Location:182 → 306

BBC; B-Box C-terminal domain

cd00063
Location:357 → 443

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

pfam18568
Location:285 → 336

COS; TRIM C-terminal subgroup One Signature domain

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

cl02614
Location:447 → 623

SPRY; SPRY domain
XM_036161835.1 → XP_036017728.1 E3 ubiquitin-protein ligase Midline-1 isoform X9

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:395 → 494

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00162
Location:10 → 59

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cl17238
Location:8 → 61

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_036161834.1 → XP_036017727.1 E3 ubiquitin-protein ligase Midline-1 isoform X8

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:395 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:485 → 552

SPRY; SPRY domain
XM_036161831.1 → XP_036017724.1 E3 ubiquitin-protein ligase Midline-1 isoform X7

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00162
Location:10 → 59

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:383 → 559

SPRY; SPRY domain

cl17238
Location:8 → 61

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_017318411.3 → XP_017173900.1 E3 ubiquitin-protein ligase Midline-1 isoform X3

Conserved Domains (8) summary

smart00502
Location:191 → 308

BBC; B-Box C-terminal domain

cd00063
Location:359 → 458

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00162
Location:10 → 59

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam18568
Location:287 → 338

COS; TRIM C-terminal subgroup One Signature domain

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

cl02614
Location:462 → 638

SPRY; SPRY domain

cl17238
Location:8 → 61

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_017318412.3 → XP_017173901.1 E3 ubiquitin-protein ligase Midline-1 isoform X4

UniProtKB/TrEMBL

B1AV01

Related

ENSMUSP00000077974.6, ENSMUST00000078947.12

Conserved Domains (6) summary

smart00502
Location:182 → 306

BBC; B-Box C-terminal domain

cd00063
Location:357 → 456

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:285 → 336

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:460 → 636

SPRY; SPRY domain
XM_017318410.3 → XP_017173899.1 E3 ubiquitin-protein ligase Midline-1 isoform X1

UniProtKB/Swiss-Prot

B1AV00, O35418, O70583, Q7TPT6

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:395 → 494

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

cl02614
Location:498 → 674

SPRY; SPRY domain
XM_036161830.1 → XP_036017723.1 E3 ubiquitin-protein ligase Midline-1 isoform X4

UniProtKB/TrEMBL

B1AV01

Conserved Domains (6) summary

smart00502
Location:182 → 306

BBC; B-Box C-terminal domain

cd00063
Location:357 → 456

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:285 → 336

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:460 → 636

SPRY; SPRY domain
XM_030251241.2 → XP_030107101.1 E3 ubiquitin-protein ligase Midline-1 isoform X2

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:395 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:485 → 661

SPRY; SPRY domain
XM_017318413.3 → XP_017173902.1 E3 ubiquitin-protein ligase Midline-1 isoform X13

Conserved Domains (8) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:472 → 520

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00162
Location:10 → 59

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

cl02614
Location:524 → 700

SPRY; SPRY domain

cl17238
Location:8 → 61

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006528736.5 → XP_006528799.1 E3 ubiquitin-protein ligase Midline-1 isoform X10

UniProtKB/TrEMBL

B1AUZ9

Conserved Domains (4) summary

smart00502
Location:24 → 77

BBC; B-Box C-terminal domain

cd00063
Location:128 → 227

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18568
Location:56 → 107

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:231 → 407

SPRY; SPRY domain
XM_006528737.5 → XP_006528800.1 E3 ubiquitin-protein ligase Midline-1 isoform X12

See identical proteins and their annotated locations for XP_006528800.1

UniProtKB/TrEMBL

B1AUZ9, Q6PD02

Related

ENSMUSP00000078412.6, ENSMUST00000079443.6

Conserved Domains (4) summary

smart00502
Location:24 → 77

BBC; B-Box C-terminal domain

cd00063
Location:128 → 214

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18568
Location:56 → 107

COS; TRIM C-terminal subgroup One Signature domain

cl02614
Location:218 → 394

SPRY; SPRY domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_183151.1: Suppressed sequence

Description

NM_183151.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.