Conserved Protein Domain Family
COS
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pfam18568: COS (this model, PSSM-Id:408352 is obsolete and has been replaced by 465805)
TRIM C-terminal subgroup One Signature domain
This domain is found in the C-terminal region of the TRIM subgroup C-1 proteins such as E3 ubiquitin-protein ligase Midline-1 protein which is required for the proper development during embryogenesis. Mutations of MID1 are associated with X-linked Opitz G syndrome, characterized by midline anomalies. This domain is also found in MURF1-3 proteins that do not contain the FNIII and B30.2 domains. MUF1-3 proteins are also associated with microtubules. Deletion of the COS domain does not affect MID1 dimerization but disrupts the localization to the microtubules.
Links
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Statistics
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PSSM-Id: 408352
Aligned: 6 rows
Threshold Bit Score: 87.7169
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
OCT67208     323 SDHARFLQGAKTVAERISMTTTSSQIPMHDVnlNDAFENFALDFSREKKLLE 374 African clawed frog
EMP28237     283 TDHPCFVQAAKQLHSRILRATASLQSFRPAA--TSSFSRFQLDLGREMKLLT 332 Green sea turtle
EOB00551     318 NQAEHILK--ENDHARVAMATASSQVLIPDInfNDAFENFALDFSREKKLHQ 367 mallard
XP_026158036 343 TDHARFLQTAKSINERvsmaTASTQVLIPEIhlTDTFDTFVLDFNREKKLLE 394 zig-zag eel
XP_010843387  34 ndharflqtakniteRVSMATASSQVLIPEInlNDTFDTFALDFSREKKLLE 85  Bison bison bison
XP_024000284  57 NDHARFLQTARNVAERVAMATASSQVLIPDVnlNEAFDNFALDFSREKKILe 108 Arctic char
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