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Nasopharyngeal Keratinizing Squamous Cell Carcinoma

MedGen UID:
1708895
•Concept ID:
C5234872
•
Neoplastic Process
Synonyms: Keratinizing Epidermoid Carcinoma of Nasopharynx; Keratinizing Epidermoid Carcinoma of the Nasopharynx; Keratinizing Squamous Cell Carcinoma of Nasopharynx; Keratinizing squamous cell carcinoma of nasopharynx; Keratinizing Squamous Cell Carcinoma of the Nasopharynx; Nasopharyngeal Keratinizing Epidermoid Carcinoma
SNOMED CT: Keratinizing squamous cell carcinoma of nasopharynx (698011002)

Definition

A squamous cell carcinoma that arises from the nasopharynx and is characterized by prominent production of keratin. [from NCI]

Professional guidelines

PubMed

Cystic form of cervical lymphadenopathy in adults. Guidelines of the French Society of Otorhinolaryngology (short version). Part 2-etiological diagnosis procedure: Clinical and imaging assessment.
Santini L, Favier V, Benoudiba F, Garcia G, Abgral R, Zerdoud S, Russ G, Bozec A, Tronche S, Pondaven S, Garrel R, de Monès E
Eur Ann Otorhinolaryngol Head Neck Dis 2020 Mar;137(2):117-121. Epub 2020 Feb 26 doi: 10.1016/j.anorl.2019.11.003. PMID: 32114087
Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma.
Singh L, Ranjan R, Arava S, Singh MK
Ann Diagn Pathol 2014 Oct;18(5):261-5. Epub 2014 Jan 13 doi: 10.1016/j.anndiagpath.2014.01.003. PMID: 25017972
Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828

Recent clinical studies

Etiology

Comprehensive single-cell transcriptomic and proteomic analysis reveals NK cell exhaustion and unique tumor cell evolutionary trajectory in non-keratinizing nasopharyngeal carcinoma.
Chen C, Wang C, Pang R, Liu H, Yin W, Chen J, Tao L
J Transl Med 2023 Apr 25;21(1):278. doi: 10.1186/s12967-023-04112-8. PMID: 37098551Free PMC Article
Infectious Agents Associated with Head and Neck Carcinomas.
Hettmann A, Demcsák A, Decsi G, Bach Á, Pálinkó D, Rovó L, Nagy K, Takács M, Minarovits J
Adv Exp Med Biol 2016;897:63-80. doi: 10.1007/5584_2015_5005. PMID: 26563307
Nasopharyngeal squamous cell carcinoma: a comparative analysis of keratinizing and nonkeratinizing subtypes.
Vazquez A, Khan MN, Govindaraj S, Baredes S, Eloy JA
Int Forum Allergy Rhinol 2014 Aug;4(8):675-83. Epub 2014 Apr 14 doi: 10.1002/alr.21332. PMID: 24733735
Morphologic features of conventional squamous cell carcinoma of the oropharynx: 'keratinizing' and 'nonkeratinizing' histologic types as the basis for a consistent classification system.
Chernock RD
Head Neck Pathol 2012 Jul;6 Suppl 1(Suppl 1):S41-7. Epub 2012 Jul 3 doi: 10.1007/s12105-012-0373-4. PMID: 22782222Free PMC Article
Histopathological classification of nasopharyngeal carcinoma.
Wei KR, Xu Y, Liu J, Zhang WJ, Liang ZH
Asian Pac J Cancer Prev 2011;12(5):1141-7. PMID: 21875256

Diagnosis

MDM2 is a useful diagnostic marker for nasopharyngeal carcinoma.
Taverna C, Agaimy A, Franchi A
Pathol Res Pract 2022 Aug;236:153978. Epub 2022 Jun 11 doi: 10.1016/j.prp.2022.153978. PMID: 35714490
Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in the United States.
Xu Y, Huang T, Mao M, Zhai J, Chen J
Laryngoscope 2021 Apr;131(4):E1130-E1138. Epub 2020 Aug 24 doi: 10.1002/lary.28983. PMID: 32833262
Nasopharyngeal squamous cell carcinoma: a comparative analysis of keratinizing and nonkeratinizing subtypes.
Vazquez A, Khan MN, Govindaraj S, Baredes S, Eloy JA
Int Forum Allergy Rhinol 2014 Aug;4(8):675-83. Epub 2014 Apr 14 doi: 10.1002/alr.21332. PMID: 24733735
Histopathological classification of nasopharyngeal carcinoma.
Wei KR, Xu Y, Liu J, Zhang WJ, Liang ZH
Asian Pac J Cancer Prev 2011;12(5):1141-7. PMID: 21875256
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Therapy

Re-irradiation with Moderate Hypo-fractionation Using Intensity Modulated Photon or Proton Radiation Therapy in Locally Recurrent Squamous Cell Carcinoma of Nasopharynx.
Nam H, Ahn YC, Yang K, Oh D, Noh JM
Cancer Res Treat 2022 Jan;54(1):96-108. Epub 2021 Mar 26 doi: 10.4143/crt.2020.1349. PMID: 33781049Free PMC Article
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article
Locally advanced nasopharyngeal cancer.
Ensley JF, Youssef E, Kim H, Yoo G
Curr Treat Options Oncol 2001 Feb;2(1):15-23. doi: 10.1007/s11864-001-0013-9. PMID: 12057137
The significance of keratinizing squamous cell histology in Chinese patients with nasopharyngeal carcinoma.
Chan AT, Teo ML, Lee WY, Kwan WH, Choi PH, Johnson PJ
Clin Oncol (R Coll Radiol) 1998;10(3):161-4. doi: 10.1016/s0936-6555(98)80057-5. PMID: 9704177
Undifferentiated nasopharyngeal cancer (UCNT): current diagnostic and therapeutic aspects.
Altun M, Fandi A, Dupuis O, Cvitkovic E, Krajina Z, Eschwege F
Int J Radiat Oncol Biol Phys 1995 Jun 15;32(3):859-77. doi: 10.1016/0360-3016(95)00516-2. PMID: 7790274

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in the United States.
Xu Y, Huang T, Mao M, Zhai J, Chen J
Laryngoscope 2021 Apr;131(4):E1130-E1138. Epub 2020 Aug 24 doi: 10.1002/lary.28983. PMID: 32833262
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223
Nasopharyngeal squamous cell carcinoma: a comparative analysis of keratinizing and nonkeratinizing subtypes.
Vazquez A, Khan MN, Govindaraj S, Baredes S, Eloy JA
Int Forum Allergy Rhinol 2014 Aug;4(8):675-83. Epub 2014 Apr 14 doi: 10.1002/alr.21332. PMID: 24733735
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Clinical prediction guides

Construction of Prognostic Nomogram in Patients with N3-Stage Nasopharyngeal Carcinoma.
Cao W, Li X, Yang J, Xing E, Wu W, Ge Y, Wang B
ORL J Otorhinolaryngol Relat Spec 2023;85(4):195-207. Epub 2023 May 5 doi: 10.1159/000530053. PMID: 37232012
Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in the United States.
Xu Y, Huang T, Mao M, Zhai J, Chen J
Laryngoscope 2021 Apr;131(4):E1130-E1138. Epub 2020 Aug 24 doi: 10.1002/lary.28983. PMID: 32833262
Nonkeratinizing Nasopharyngeal Carcinoma, Undifferentiated Type With Trisomy 2: A Case Report and Short Review of Cytogenetic and Molecular Literature.
Pontoriero F, Silverman AM, Pascasio JM, Bajaj R
Pediatr Dev Pathol 2020 Nov-Dec;23(6):448-452. Epub 2020 Aug 5 doi: 10.1177/1093526620945861. PMID: 32755442
Immunotherapy in head and neck cancers: A new challenge for immunologists, pathologists and clinicians.
Outh-Gauer S, Alt M, Le Tourneau C, Augustin J, Broudin C, Gasne C, Denize T, Mirghani H, Fabre E, Ménard M, Scotte F, Tartour E, Badoual C
Cancer Treat Rev 2018 Apr;65:54-64. Epub 2018 Mar 1 doi: 10.1016/j.ctrv.2018.02.008. PMID: 29547766
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223

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