Abstract
Six hundred and ninety-three Chinese patients with non-metastatic nasopharyngeal carcinoma (NPC) were treated at one institution under a uniform protocol between 1984 and 1989. The tumour histology of these patients was subjected to a standardized review and classified into two distinct groups of World Health Organization (WHO) type I (keratinizing squamous cell carcinoma) (n = 13) or WHO types II and III (non-keratinizing carcinoma and undifferentiated carcinoma) (n = 662). The differentiation between the two groups was uncertain in 18 patients. The patient characteristics and clinical outcome after a uniform treatment policy of the two groups were not statistically significantly different. The low incidence of WHO type I NPC may account for the lack of prognostic significance of this histological subtype in Chinese populations.
MeSH terms
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Actuarial Analysis
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Biopsy
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Carcinoma / classification
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Carcinoma / pathology*
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Carcinoma / radiotherapy
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Carcinoma / secondary
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Carcinoma in Situ / classification
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Carcinoma in Situ / pathology
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Carcinoma in Situ / radiotherapy
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Carcinoma in Situ / secondary
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Carcinoma, Squamous Cell / classification
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Carcinoma, Squamous Cell / pathology*
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Carcinoma, Squamous Cell / radiotherapy
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Carcinoma, Squamous Cell / secondary
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Confidence Intervals
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Disease-Free Survival
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Female
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Humans
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Incidence
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Iridium Radioisotopes / therapeutic use
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Keratins
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Male
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Middle Aged
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Nasopharyngeal Neoplasms / classification
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Nasopharyngeal Neoplasms / pathology*
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Nasopharyngeal Neoplasms / radiotherapy
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Neoplasm Recurrence, Local
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Odds Ratio
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Prognosis
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Proportional Hazards Models
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Radiopharmaceuticals / therapeutic use
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Radiotherapy Dosage
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Survival Rate
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Treatment Outcome
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World Health Organization
Substances
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Iridium Radioisotopes
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Radiopharmaceuticals
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Keratins