|
| Status |
Public on Jul 01, 2007 |
| Title |
Genome wide analysis of placental malaria |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Chronic inflammation during placental malaria (PM) caused by Plasmodium falciparum is most frequent in first-time mothers and is associated with poor maternal and fetal outcomes. In the first genome wide analysis of the local human response to sequestered malaria parasites, we identified genes associated with chronic PM, then localized the corresponding proteins and immune cell subsets in placental cryosections.
Keywords: Disease state analysis
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| |
|
| Overall design |
Placental samples from twenty first-time mothers were selected based on placental malaria (PM) status and RNA quality. Ten had active PM-episodes, seven of which had inflammatory cells on histology. Of the ten PM-negative women, five had histological evidence of a past PM-episode, including one with inflammatory cells.
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| |
|
| Contributor(s) |
Muehlenbachs A, Duffy PE, Fried M, Mutabingwa TK |
| Citation(s) |
17579077 |
| Submission date |
Apr 23, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Atis Muehlenbachs |
| E-mail(s) |
amuehlen@u.washington.edu
|
| Organization name |
Seattle Biomedical Research Institute
|
| Street address |
307 Westlake Ave N
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (20)
|
| GSM183605 |
placenta-0449-uninflamed-uninfected-rep1 |
| GSM183606 |
placenta-0502-uninflamed-uninfected-rep1 |
| GSM183607 |
placenta-0517-uninflamed-uninfected-rep1 |
| GSM183608 |
placenta-0606-uninflamed-uninfected-rep1 |
| GSM183609 |
placenta-0735-uninflamed-uninfected-rep1 |
| GSM183610 |
placenta-0460-inflamed-infected-rep1 |
| GSM183611 |
placenta-0491-uninflamed-infected-rep1 |
| GSM183612 |
placenta-0543-inflamed-infected-rep1 |
| GSM183613 |
placenta-0545-uninflamed-infected-rep1 |
| GSM183614 |
placenta-0586-inflamed-infected-rep1 |
| GSM183615 |
placenta-0638-inflamed-infected-rep1 |
| GSM183616 |
placenta-0660-inflamed-infected-rep1 |
| GSM183617 |
placenta-0687-inflamed-infected-rep1 |
| GSM183618 |
placenta-0702-uninflamed-infected-rep1 |
| GSM183619 |
placenta-0716-inflamed-infected-rep1 |
| GSM183620 |
placenta-0409-uninflamed-past-rep1 |
| GSM183621 |
placenta-0475-uninflamed-past-rep1 |
| GSM183622 |
placenta-0482-uninflamed-past-rep1 |
| GSM183623 |
placenta-0540-inflamed-past-rep1 |
| GSM183624 |
placenta-0649-uninflamed-past-rep1 |
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| Relations |
| BioProject |
PRJNA100185 |
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