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| Status |
Public on Nov 30, 2014 |
| Title |
DNA methylation study in breast cancer [aCGH] |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
Addressing the still unresolved question of the existence of CIMP in breast cancer DNA methylation alterations among histological breast cancer subtypes were examined by applying the HM450K BeadChip of Illumina Inc., covering about 480,000 single CpG sites. In addition to the occurrence of the hypermethylator phenotype in breast cancer, its relation to genetic instability and histological subtypes was investigated.
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| Overall design |
Bisulfite converted DNA from 32 fresh-frozen primary breast tissue samples and 4 breast cancer cell lines were hybridized onto the HumanMethylation 450K BeadChip from Illumina Inc. Additionally, 28 of these primary samples were analyzed by array-based comparative hybdridization (aCGH).
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| Contributor(s) |
Rößler J, Lehmann U, Ammerpohl O, Gutwein J, Steinemann D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 30, 2014 |
| Last update date |
Nov 30, 2014 |
| Contact name |
Jessica Rößler |
| Organization name |
Medical School Hannover
|
| Department |
Pathology
|
| Street address |
Carl-Neuberg Str. 1
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| City |
Hannover |
| ZIP/Postal code |
30625 |
| Country |
Germany |
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| Platforms (1) |
| GPL10123 |
Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version) |
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| Samples (28)
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| This SubSeries is part of SuperSeries: |
| GSE59903 |
DNA methylation study in breast cancer |
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| Relations |
| BioProject |
PRJNA257040 |
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