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Series GSE59157 Query DataSets for GSE59157
Status Public on Jul 08, 2014
Title Methylome analysis of normal kidney, nephrogenic rest and Wilms tumor
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Genome wide DNA methylation profiling of normal kidney (n=36), nephrogenic rest (n=22) and Wilms tumour (n=37) was performed using the Illumina 450k array. Two papers were composed after analysis of this data (1) describes comparative analysis of 22 matched normal kidney-Wilms tumour pairs which identified biomarker differentially methylated regions (DMRs) that could be detected in patient blood; (2) describes comparative analysis of 20 matched trios which identified changes in methylation associated with progression from the precursor lesion towards tumourigenesis.
 
Overall design Bisulfte converted DNA from 95 samples of normal kidney, nephrogenic rest and Wilms tumour was hybridised to Illumina HumanMethylation450 bead chips.
 
Contributor(s) Charlton J, Williams RD, Weeks M, Sebire NJ, Popov S, Vujanic G, Mifsud W, Chagtai T, Maschietto M, Alcaide-German M, Morris T, Butcher LM, Guilhamon P, Beck S, Pritchard-Jones K
Citation(s) 25134821
Submission date Jul 07, 2014
Last update date Mar 22, 2019
Contact name Jocelyn Charlton
E-mail(s) jocelyn.charlton.11@ucl.ac.uk
Phone 07969338982
Organization name University College London
Department Institute of Child Health
Street address 30 Guilford Street
City London
ZIP/Postal code WC1N 1EH
Country United Kingdom
 
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (95)
GSM1429528 genomic DNA from formalin fixed paraffin embedded normal kidney 1
GSM1429529 genomic DNA from formalin fixed paraffin embedded normal kidney 2
GSM1429530 genomic DNA from formalin fixed paraffin embedded normal kidney 3
Relations
BioProject PRJNA254506

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE59157_RAW.tar 183.1 Mb (http)(custom) TAR
GSE59157_signal_intensities.txt.gz 212.8 Mb (ftp)(http) TXT
Processed data included within Sample table
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