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Series GSE53192

Query DataSets for GSE53192

Status

Public on Dec 11, 2013

Title

DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women (Agilent)

Organism

Experiment type

Methylation profiling by genome tiling array

Summary

High frequency of physical aggression is the central feature of severe conduct disorder and is associated with a wide range of social, mental and physical health problems. We have previously tested the hypothesis that differential DNA methylation signatures in peripheral T cells are associated with a chronic aggression trajectory in males. Despite the fact that sex differences appear to play a pivotal role in determining the development, magnitude and frequency of aggression, most of previous studies focused on males, so little is known about female chronic physical aggression. We therefore tested here whether or not there is a signature of physical aggression in female DNA methylation and, if there is, how it relates to the signature observed in males.

Overall design

Genome-wide promoter methylation profiles of T cell DNA from adult females on a Chronic Physical Aggression (CPA, n=5) trajectory during childhood and adolescence were compared to those on normative physical aggression trajectories (NPA, n=14). Two technical replicates were generated for each individual.

Contributor(s)

Guillemin C, Provencal N, Suderman M, Cote SM, Vitaro F, Hallett M, Tremblay RE, Moshe S

Citation(s)

Submission date

Dec 10, 2013

Last update date

Jun 04, 2021

Contact name

Moshe Szyf

E-mail(s)

moshe.szyf@mcgill.ca

Organization name

McGill University

Department

Pharmacology

Street address

McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 1309

City

Montreal

State/province

Quebec

ZIP/Postal code

H3G 1Y6

Country

Canada

Platforms (1)

Agilent-027346 human hg18 promoters 180K

Samples (38)

More...

GSM1286188	T cell (CD3 positive)_medip_chronic_aggressivity.1
GSM1286189	T cell (CD3 positive)_medip_chronic_aggressivity.2
GSM1286190	T cell (CD3 positive)_medip_control_aggressivity.1

GSM1286191	T cell (CD3 positive)_medip_control_aggressivity.2
GSM1286192	T cell (CD3 positive)_medip_control_aggressivity.3
GSM1286193	T cell (CD3 positive)_medip_control_aggressivity.4
GSM1286194	T cell (CD3 positive)_medip_control_aggressivity.5
GSM1286195	T cell (CD3 positive)_medip_control_aggressivity.6
GSM1286196	T cell (CD3 positive)_medip_chronic_aggressivity.3
GSM1286197	T cell (CD3 positive)_medip_chronic_aggressivity.4
GSM1286198	T cell (CD3 positive)_medip_chronic_aggressivity.5
GSM1286199	T cell (CD3 positive)_medip_chronic_aggressivity.6
GSM1286200	T cell (CD3 positive)_medip_control_aggressivity.7
GSM1286201	T cell (CD3 positive)_medip_control_aggressivity.8
GSM1286202	T cell (CD3 positive)_medip_control_aggressivity.9
GSM1286203	T cell (CD3 positive)_medip_control_aggressivity.10
GSM1286204	T cell (CD3 positive)_medip_control_aggressivity.11
GSM1286205	T cell (CD3 positive)_medip_control_aggressivity.12
GSM1286206	T cell (CD3 positive)_medip_chronic_aggressivity.7
GSM1286207	T cell (CD3 positive)_medip_chronic_aggressivity.8
GSM1286208	T cell (CD3 positive)_medip_control_aggressivity.13
GSM1286209	T cell (CD3 positive)_medip_control_aggressivity.14
GSM1286210	T cell (CD3 positive)_medip_control_aggressivity.15
GSM1286211	T cell (CD3 positive)_medip_control_aggressivity.16
GSM1286212	T cell (CD3 positive)_medip_control_aggressivity.17
GSM1286213	T cell (CD3 positive)_medip_control_aggressivity.18
GSM1286214	T cell (CD3 positive)_medip_control_aggressivity.19
GSM1286215	T cell (CD3 positive)_medip_control_aggressivity.20
GSM1286216	T cell (CD3 positive)_medip_chronic_aggressivity.9
GSM1286217	T cell (CD3 positive)_medip_chronic_aggressivity.10
GSM1286218	T cell (CD3 positive)_medip_control_aggressivity.21
GSM1286219	T cell (CD3 positive)_medip_control_aggressivity.22
GSM1286220	T cell (CD3 positive)_medip_control_aggressivity.23
GSM1286221	T cell (CD3 positive)_medip_control_aggressivity.24
GSM1286222	T cell (CD3 positive)_medip_control_aggressivity.25
GSM1286223	T cell (CD3 positive)_medip_control_aggressivity.26
GSM1286224	T cell (CD3 positive)_medip_control_aggressivity.27
GSM1286225	T cell (CD3 positive)_medip_control_aggressivity.28

This SubSeries is part of SuperSeries:

DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women

Relations

BioProject

Download family	Format
SOFT formatted family file(s)	SOFT
MINiML formatted family file(s)	MINiML
Series Matrix File(s)	TXT

Supplementary file	Size	Download	File type/resource
GSE53192_RAW.tar	798.1 Mb	(http)(custom)	TAR (of TXT)
Processed data included within Sample table

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