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| Status |
Public on Oct 01, 2014 |
| Title |
Inhalation of rod-like carbon nanotubes causes unconventional asthma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Exposure to rod-shaped carbon nanotubes reveals novel innate immunity mediated asthma-like inflammation in mice. Inhalation of rCNT elicited a drastic infiltration of eosinophils into the lungs but only minor infiltration of neutrophils and lymphocytes. Transcriptomic study revealed remarkable effects of rCNT exposure, affecting almost exclusively pathways essential for innate immunity.
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| Overall design |
Mice were exposed to rCNT or tCNT for 4 h and sacrificed immediately or 24 h after the exposure. The total RNA was extracted from lung samples, hybridized to Agilent microarray and analyzed with BioConductor package Limma. Untreated mice were used as control.
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| Contributor(s) |
Rydman E, Ilves M, Koivisto J, Kinaret P, Fortino V, Savinko T, Lehto M, Pulkkinen V, Vippola M, Hämeri K, Matikainen S, Wolff H, Savolainen K, Greco D, Alenius H |
| Citation(s) |
25318534 |
| Submission date |
Aug 25, 2013 |
| Last update date |
Jun 17, 2019 |
| Contact name |
Dario Greco |
| E-mail(s) |
dario.greco@tuni.fi
|
| Organization name |
Tampere University
|
| Department |
Faculty of Medicine and Health Technology
|
| Lab |
Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE)
|
| Street address |
Arvo ylpön Katu 34
|
| City |
Tampere |
| ZIP/Postal code |
33520 |
| Country |
Finland |
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| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA216968 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE50176_Pool1+Pool2_US23502401_252800516533_S01_GE2_1100_Jul11_1_1.txt.gz |
6.0 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool11+Pool12_US23502401_252800516533_S01_GE2_1100_Jul11_2_2.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool13+Pool14_US23502401_252800516533_S01_GE2_1100_Jul11_2_3.txt.gz |
6.0 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool15+Pool16_US23502401_252800516533_S01_GE2_1100_Jul11_2_4.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool17+Pool18_US23502401_252800516534_S01_GE2_1100_Jul11_1_1.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool19+Pool20_US23502401_252800516534_S01_GE2_1100_Jul11_1_2.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool21+Pool22_US23502401_252800516534_S01_GE2_1100_Jul11_1_3.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool23+Pool24_US23502401_252800516534_S01_GE2_1100_Jul11_1_4.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool3+Pool4_US23502401_252800516533_S01_GE2_1100_Jul11_1_2.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool5+Pool6_US23502401_252800516533_S01_GE2_1100_Jul11_1_3.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool7+Pool8_US23502401_252800516533_S01_GE2_1100_Jul11_1_4.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_Pool9+Pool10_US23502401_252800516533_S01_GE2_1100_Jul11_2_1.txt.gz |
6.1 Mb |
(ftp)(http) |
TXT |
| GSE50176_RAW.tar |
7.9 Mb |
(http)(custom) |
TAR |
| Processed data included within Sample table |
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