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| Status |
Public on Nov 08, 2012 |
| Title |
Gene Expression Levels in PiZ mice Compared to Wild-type (Wt)C57Bl/6 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Individuals expressing alpha-1-antitrypsin mutant Z protein accumulate misfolded, mutant protein in the liver and are at risk for liver diseases including cirrhosis and hepatocellular carcinoma. Transgenic PiZ mice, a model for this liver disease, display similar pathologies to humans, including inflammation, increases in proliferation, autophagy and apoptosis, accumulation of globules and develop fibrosis and hepatocellular carcinoma with age. Microarrays were used to compare the gene expressions of PiZ mice to wild-type mice in order to identify the pathways that are altered in this disorder.
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| Overall design |
Pooled samples from 4 mice, 3-4 months old were used for each of 4 categories. PiZ males, PiZ females, C57Bl/6 males, C57Bl/6 females
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| Contributor(s) |
Teckman JH, Rudnick DA, Blomenkamp K |
| Citation(s) |
23104507 |
| Submission date |
Mar 13, 2012 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Nancy Marcus |
| E-mail(s) |
nmarcus@slu.edu
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| Organization name |
St. Louis University
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| Department |
Pediatrics
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| Lab |
Teckman
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| Street address |
1100 S. Grand,Doisy Research Center
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| City |
St. Louis |
| State/province |
Missouri |
| ZIP/Postal code |
63104 |
| Country |
USA |
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| Platforms (2) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
| GPL340 |
[MOE430B] Affymetrix Mouse Expression 430B Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA153511 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE36478_RAW.tar |
27.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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