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| Status |
Public on Feb 01, 2024 |
| Title |
Transcriptome profiles of malignant peritoneal mesotheliomas of rats induced by multiwalled carbon nanotubes (MWCNTs) and amosite asbestos |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Malignant mesothelioma is an aggressive cancer that often originates in the pleural and peritoneal mesothelium. Exposure to asbestos is a frequent cause. But studies in rodents showed that certain multiwalled carbon nanotubes (MWCNTs) can induce malignant mesotheliomas. This study aimed to understand molecular pathways leading to the development of malignant mesotheliomas induced by MWCNTs and amosite asbestos in Wistar rats.
Using Affymetrix microarrays, we carried out genome-wide transcriptome analysis on malignant peritoneal meosotheliomas induced by MWCNTs and amosite asbestos. The transcriptome of MWCNTs and amosite asbestos-induced mesotheliomas exhibited commonalities, but also differences pertaining to differentially-expressed genes (DEGs), regulated canonical pathways, and molecular functions.
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| Overall design |
Malignant mesotheliomas were induced by peritoneal treatments of MWCNTs and amosite asbestos in Wistar rats. Tumor and control peritoneal tissues were part of an in vivo study to determine carcinogenic effects of various MWCNTs (Rittinghausen et al 2014, Particle and fibre toxicology 11, 59). Genome-wide transcriptome analysis using Affymetrix microarrays was undertaken in n =11 tumors from different rats induced by MWCNTs and amosite asbestos, and n = 3 control peritoneal tissues.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/38297314/
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| Contributor(s) |
Reamon-Buettner SM |
| Citation(s) |
38297314 |
| Submission date |
May 31, 2023 |
| Last update date |
Feb 02, 2024 |
| Contact name |
Stella Marie Reamon-Buettner |
| E-mail(s) |
stella.reamon-buettner@item.fraunhofer.de
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| Phone |
+49 511 5350 527
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| Organization name |
Fraunhofer-ITEM
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| Department |
Preclinical Pharmacology & In Vitro Toxicology
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| Street address |
Nikolai-Fuchs Strasse1
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| City |
Hannover |
| ZIP/Postal code |
30625 |
| Country |
Germany |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (14)
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| GSM7437099 |
MWCNT D-induced rat mesothelioma, biological rep 1 |
| GSM7437100 |
MWCNT D-induced rat mesothelioma, biological rep 2 |
| GSM7437101 |
MWCNT D-induced rat mesothelioma, biological rep 3 |
| GSM7437102 |
MWCNT C-induced rat mesothelioma, biological rep 1 |
| GSM7437103 |
MWCNT C-induced rat mesothelioma, biological rep 2 |
| GSM7437104 |
MWCNT C-induced rat mesothelioma, biological rep 3 |
| GSM7437105 |
MWCNT B-inducedd rat mesothelioma, biological rep 1 |
| GSM7437106 |
MWCNT B-induced rat mesothelioma, biological rep 2 |
| GSM7437107 |
Amosite-induced rat mesothelioma, biological rep 1 |
| GSM7437108 |
Amosite-induced rat mesothelioma, biological rep 2 |
| GSM7437109 |
Amosite-induced rat mesothelioma, biological rep 3 |
| GSM7437110 |
sham-treated rat peritoneal tissue, biological rep 1 |
| GSM7437111 |
sham-treated rat peritoneal tissue, biological rep 2 |
| GSM7437112 |
sham-treated rat peritoneal tissue, biological rep 3 |
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| Relations |
| BioProject |
PRJNA978013 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE233803_RAW.tar |
40.0 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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