The Oligo GEArray® Human DNA Damage Signaling Pathway Microarray profiles the expression of 113 genes involved in DNA damage signaling pathways. The genes associated with the ATR / ATM signaling network and transcriptional targets of DNA damage response are included on this array. Genes related to cell cycle arrest, apoptosis, and the stabilization and repair of the cellular genome as a result of DNA damage signaling are represented as well. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples with this array.Total genomic DNA was spotted on 13 spots for positive control. Nothing was spotted on 2 spot with the aim of negative control. Therefore, a total of 15 spot data were already eliminated from the whole 128 spot data on this array. HybTube Format. >>> Functional Gene Grouping <<< Apoptosis Genes: ABL1, BRCA1, CIDEA, CIDEB, GADD45A, GADD45G, GML, IHPK3, PCBP4, PDCD8, PPP1R15A, RAD21, TP53, TP73. Cell Cycle Genes: Cell Cycle Arrest: CHEK1, CHEK2, DDIT3, GADD45A, GML, GTSE1, HUS1, MAP2K6, MAPK12, PCBP4, PPP1R15A, RAD17, RAD9A, SESN1, ZAK. Cell Cycle Checkpoint: ATR, BRCA1, FANCG, NBS1, RAD1, RBBP8, SMC1L1, TP53. DNA Repair: Damaged DNA Binding: ANKRD17, BRCA1, DDB1, DDB2, DMC1, ERCC1, ERCC3, FANCG, FEN1, GTF2H3, MPG, MSH2, MSH3, MSH4, MSH5, MSH6, N4BP2, NBS1, OGG1, PMS2L4, PMS2L9, PNKP, RAD1, RAD18, RAD51, RAD51C, RAD51L1, RAD51L3, REV1L, SEMA4A, XPA, XPC, XRCC1, XRCC2, XRCC3. Base-excision Repair: APEX1, MBD4, MPG, MUTYH, NTHL1, OGG1, RAD51L3, UNG, UNG2. Double-strand Break Repair: BRCA2, CIB1, FEN1, G22P1, KUB3, MRE11A, NBS1, PRKDC, RAD21, RAD50, RAD52, XRCC4, XRCC5. Mismatch Repair: ABL1, ANKRD17, EXO1, MLH1, MLH3, MSH2, MSH3, MSH4, MSH5, MSH6, MUTYH, N4BP2, PMS1, PMS2, PMS2L4, PMS2L9, TP73, TREX1. Other Genes Involved in DNA Repair: APEX2, ATM, ATRX, BTG2, CCNH, CDK7, CKN1, CRY1, CRY2, ERCC2, ERCC4, ERCC5, GTF2H1, GTF2H2, IGHMBP2, INPPL1, LIG1, LIG3, LIG4, MNAT1, NUDT1, PCNA, RAD23A, RAD23B, RAD54L, RPA1, RPA3, SUMO1, TREX2.
