|
Status |
Public on Dec 17, 2009 |
Title |
DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
|
Summary |
[original title] Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays.
The aim of the study was to obtain stable radioresistant sub-lines from the human cervical cancer cell line HeLa by prolonged exposure to 252Cf neutron and X-rays. Radioresistance mechanisms were investigated in the resulting cells using SuperArray Oligo GEArray® Human DNA Damage Signaling Pathway Microarray.
|
|
|
Overall design |
HeLa cells were treated with fractionated 252Cf neutron and X-rays, with a cumulative dose of 75 Gy each, over 8 months, yielding the sub-lines HeLaNR and HeLaXR.Gene expression patterns of the radioresistant sub-lines were studied through microarray analysis
|
|
|
Contributor(s) |
Yi Q, Dong W |
Citation(s) |
20184742 |
Submission date |
Dec 17, 2009 |
Last update date |
Mar 21, 2012 |
Contact name |
yi qing |
E-mail(s) |
qywxbb@hotmail.com
|
Organization name |
Third Military Medical University
|
Department |
Daping Hospital and Research Institute of Surgery
|
Lab |
Cancer Center
|
Street address |
No.10 Changjiangzhi Rd
|
City |
Chongqing |
State/province |
Chongqing |
ZIP/Postal code |
400042 |
Country |
China |
|
|
Platforms (1) |
GPL9811 |
Oligo GEArray Human DNA Damage Signaling Pathway Microarray |
|
Samples (3) |
|
Relations |
BioProject |
PRJNA122241 |