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    Hivep1 human immunodeficiency virus type I enhancer binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 110521, updated on 9-May-2024

    Summary

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    Official Symbol
    Hivep1provided by MGI
    Official Full Name
    human immunodeficiency virus type I enhancer binding protein 1provided by MGI
    Primary source
    MGI:MGI:96100
    See related
    Ensembl:ENSMUSG00000021366 AllianceGenome:MGI:96100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cryabp1
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and musculoskeletal system. Orthologous to human HIVEP1 (HIVEP zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 7.2), colon adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A4; 13 20.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (42205304..42338504)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (42051899..42185030)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32555 Neighboring gene STARR-positive B cell enhancer ABC_E925 Neighboring gene STARR-positive B cell enhancer ABC_E5390 Neighboring gene predicted gene 28707 Neighboring gene STARR-positive B cell enhancer mm9_chr13:42189027-42189327 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:42196875-42197076 Neighboring gene predicted gene, 32778 Neighboring gene STARR-seq mESC enhancer starr_34312 Neighboring gene VISTA enhancer mm235 Neighboring gene STARR-seq mESC enhancer starr_34313 Neighboring gene STARR-seq mESC enhancer starr_34315 Neighboring gene endothelin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine transcription factor alpha A-crystallin binding protein I. Complete sequence, gene structure, expression, and functional inhibition via antisense RNA. Brady JP, et al. J Biol Chem, 1995 Jan 20. PMID 7836383
    2. The alpha A-crystallin gene: conserved features of the 5'-flanking regions in human, mouse, and chicken. Jaworski CJ, et al. J Mol Evol, 1991 Dec. PMID 1779432
    3. Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. Nakamura T, et al. Mol Cell Biol, 1990 Jul. PMID 1694016, Free PMC Article
    4. Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter. Chong SS, et al. Am J Physiol, 1995 Jun. PMID 7611445
    5. Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. Yang X, et al. J Biol Chem, 2005 May 13. PMID 15778499

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MINT is involved in CRYBP1-mediated Col2a1 gene repression and may play a role in regulation of cartilage development
      Title: Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables HMG box domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 40
    Names
    HIV type I enhancer binding protein 1
    alpha A-CRYBP1
    alpha A-crystallin-binding protein 1
    alpha A-crystallin-binding protein I
    alphaA-CRYBP1
    crystallin, alpha binding protein 1
    transcription factor alphaA-CRYBP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007772.2 → NP_031798.2  zinc finger protein 40

      See identical proteins and their annotated locations for NP_031798.2

      Status: VALIDATED

      Source sequence(s)
      AC159258
      Consensus CDS
      CCDS36643.1
      UniProtKB/Swiss-Prot
      Q03172
      UniProtKB/TrEMBL
      F8VPM9
      Related
      ENSMUSP00000056147.6, ENSMUST00000060148.6
      Conserved Domains (5) summary
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:2076 → 2096
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:2074 → 2096
      zf-C2H2; Zinc finger, C2H2 type
      pfam12756
      Location:2102 → 2167
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:422 → 446
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      42205304..42338504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516839.5 → XP_006516902.1  zinc finger protein 40 isoform X1

      See identical proteins and their annotated locations for XP_006516902.1

      UniProtKB/Swiss-Prot
      Q03172
      Conserved Domains (6) summary
      smart00451
      Location:2099 → 2130
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:2298 → 2691
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:2076 → 2096
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:2074 → 2096
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:422 → 446
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006516840.5 → XP_006516903.1  zinc finger protein 40 isoform X1

      See identical proteins and their annotated locations for XP_006516903.1

      UniProtKB/Swiss-Prot
      Q03172
      Conserved Domains (6) summary
      smart00451
      Location:2099 → 2130
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:2298 → 2691
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:2076 → 2096
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:2074 → 2096
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:422 → 446
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017315358.3 → XP_017170847.1  zinc finger protein 40 isoform X1

      UniProtKB/Swiss-Prot
      Q03172
      Conserved Domains (6) summary
      smart00451
      Location:2099 → 2130
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:2298 → 2691
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:2076 → 2096
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:2074 → 2096
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:422 → 446
      zf-H2C2_2; Zinc-finger double domain

    4. XM_030247127.2 → XP_030102987.1  zinc finger protein 40 isoform X2

      UniProtKB/Swiss-Prot
      Q03172
      Conserved Domains (6) summary
      smart00451
      Location:1982 → 2013
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:2181 → 2574
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:292 → 312
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1959 → 1979
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1957 → 1979
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305 → 329
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03172.1 GenPept UniProtKB/Swiss-Prot:Q03172

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