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Conserved domains on  [gi|117938312|ref|NP_031798|]
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zinc finger protein 40 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 2275-2668 3.06e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 3.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2275 PPADTPRSPGHQLSVHSSESDVLRSPAAGNPAAGSPGA-AVQDSSVGLPPAVAQLNPQPAARisssvSPHPDSQDQKQQI 2353
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDpRGPAPPSPLPPDTHAPDPPPPSP-----SPAANEPDPHPPP 2644

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2354 ILQPPPGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVTAGLTYSTFVPIQAGPMQLTIPAVSVIHRTVGTSGDTI 2433
Cdd:PHA03247 2645 TVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPG 2724

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2434 TEASGAPNRPTGVAELSSVVPCIPIgqihVPGLQNlsPPALQSLTSLGMETvnlvglANATVGPQGHPPGLALNAVGLQV 2513
Cdd:PHA03247 2725 PAAARQASPALPAAPAPPAVPAGPA----TPGGPA--RPARPPTTAGPPAP------APPAAPAAGPPRRLTRPAVASLS 2792

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2514 LANAPAQSSPAPPAHIQGLQILNIALPTLIPSVGPVAVGTTGTPETTAPNSKAMELQMPAGQGHSAEPP---QGSPEGPQ 2590
Cdd:PHA03247 2793 ESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrRPPSRSPA 2872

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117938312 2591 ETPQTVSGPSADH-ARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPTPEALQKVATSAPPSLPTDRAAPRPPVPHRQP 2668
Cdd:PHA03247 2873 AKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951
zf-H2C2_2 pfam13465
Zinc-finger double domain;
2088-2113 1.04e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.04e-05
                           10        20
                   ....*....|....*....|....*.
gi 117938312  2088 MLKKHIRTHTDVRPYHCSYCNFSFKT 2113
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
422-446 8.61e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 8.61e-05
                           10        20
                   ....*....|....*....|....*
gi 117938312   422 LLKHIRSHTGERPYPCVTCGFSFKT 446
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 2074-2096 2.16e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 2.16e-04
                           10        20
                   ....*....|....*....|...
gi 117938312  2074 YICEECGIRCKKPSMLKKHIRTH 2096
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 2099-2130 1.08e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.77  E-value: 1.08e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 117938312   2099 VRPYHCSYCNFSFKTKGNLTKHMKSKAHSKKC 2130
Cdd:smart00451    1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
zf-C2H2_2 super family cl20464
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 2102-2167 4.20e-03

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


The actual alignment was detected with superfamily member pfam12756:

Pssm-ID: 463690  Cd Length: 98  Bit Score: 38.81  E-value: 4.20e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117938312  2102 YHCSYCNFSFKTKGNLTKHMKSKAHSKkcvdlgvsvglIDEQDTEESDEKQRFgcersgYDLEESD 2167
Cdd:pfam12756   50 NECLYCGKQFKSLEALRQHMRDKGHCK-----------IPYESEEEWLEIAEF------YDFSSSY 98
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2275-2668 3.06e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 3.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2275 PPADTPRSPGHQLSVHSSESDVLRSPAAGNPAAGSPGA-AVQDSSVGLPPAVAQLNPQPAARisssvSPHPDSQDQKQQI 2353
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDpRGPAPPSPLPPDTHAPDPPPPSP-----SPAANEPDPHPPP 2644

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2354 ILQPPPGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVTAGLTYSTFVPIQAGPMQLTIPAVSVIHRTVGTSGDTI 2433
Cdd:PHA03247 2645 TVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPG 2724

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2434 TEASGAPNRPTGVAELSSVVPCIPIgqihVPGLQNlsPPALQSLTSLGMETvnlvglANATVGPQGHPPGLALNAVGLQV 2513
Cdd:PHA03247 2725 PAAARQASPALPAAPAPPAVPAGPA----TPGGPA--RPARPPTTAGPPAP------APPAAPAAGPPRRLTRPAVASLS 2792

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2514 LANAPAQSSPAPPAHIQGLQILNIALPTLIPSVGPVAVGTTGTPETTAPNSKAMELQMPAGQGHSAEPP---QGSPEGPQ 2590
Cdd:PHA03247 2793 ESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrRPPSRSPA 2872

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117938312 2591 ETPQTVSGPSADH-ARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPTPEALQKVATSAPPSLPTDRAAPRPPVPHRQP 2668
Cdd:PHA03247 2873 AKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951
zf-H2C2_2 pfam13465
Zinc-finger double domain;
2088-2113 1.04e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.04e-05
                           10        20
                   ....*....|....*....|....*.
gi 117938312  2088 MLKKHIRTHTDVRPYHCSYCNFSFKT 2113
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
422-446 8.61e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 8.61e-05
                           10        20
                   ....*....|....*....|....*
gi 117938312   422 LLKHIRSHTGERPYPCVTCGFSFKT 446
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 2074-2096 2.16e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 2.16e-04
                           10        20
                   ....*....|....*....|...
gi 117938312  2074 YICEECGIRCKKPSMLKKHIRTH 2096
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2260-2664 4.20e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 4.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2260 AKARQSTEKDEHEQAPPADTPRSPGHQLSVHSSESDvlrspaagNPAAGSPGAAVQDSSVGLPPAVAQLNPQPAARISSS 2339
Cdd:pfam03154   80 AKRQREKGASDTEEPERATAKKSKTQEISRPNSPSE--------GEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSP 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2340 VSPHPDSQDQKQQIILQPPPGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVTAGLTYSTFVPIQAgpmQLTIPAV 2419
Cdd:pfam03154  152 QDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT---QSTAAPH 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2420 SVIHRTVGTSGDTITeASGAPNRPTGVAELSSVVPCIPIGQIHVPGLQNLSPPALQSLTSLGMETVNLVGLANATVGPQG 2499
Cdd:pfam03154  229 TLIQQTPTLHPQRLP-SPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQS 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2500 H---PPGLALNAVGLQVLANAPAQSSPAP--PAHIQGLQILNIALPTLIPSvgpvavgttgtPETTAPnskamelQMPAG 2574
Cdd:pfam03154  308 QvppGPSPAAPGQSQQRIHTPPSQSQLQSqqPPREQPLPPAPLSMPHIKPP-----------PTTPIP-------QLPNP 369

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2575 QGHSaEPPQGSPEGPQETPQTVSGPSADHARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPTP-----EALQKVATSAP 2649
Cdd:pfam03154  370 QSHK-HPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPvltqsQSLPPPAASHP 448

                          410
                   ....*....|....*
gi 117938312  2650 PSLPTDRAAPRPPVP 2664
Cdd:pfam03154  449 PTSGLHQVPSQSPFP 463
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 2099-2130 1.08e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.77  E-value: 1.08e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 117938312   2099 VRPYHCSYCNFSFKTKGNLTKHMKSKAHSKKC 2130
Cdd:smart00451    1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
ZnF_C2H2 smart00355
zinc finger;
2102-2123 2.41e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 37.45  E-value: 2.41e-03
                            10        20
                    ....*....|....*....|..
gi 117938312   2102 YHCSYCNFSFKTKGNLTKHMKS 2123
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRT 22
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 2102-2167 4.20e-03

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 38.81  E-value: 4.20e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117938312  2102 YHCSYCNFSFKTKGNLTKHMKSKAHSKkcvdlgvsvglIDEQDTEESDEKQRFgcersgYDLEESD 2167
Cdd:pfam12756   50 NECLYCGKQFKSLEALRQHMRDKGHCK-----------IPYESEEEWLEIAEF------YDFSSSY 98
ZnF_C2H2 smart00355
zinc finger;
435-457 6.96e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 6.96e-03
                            10        20
                    ....*....|....*....|...
gi 117938312    435 YPCVTCGFSFKTKSNLYKHKKSH 457
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
2074-2096 9.44e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 9.44e-03
                            10        20
                    ....*....|....*....|...
gi 117938312   2074 YICEECGIRCKKPSMLKKHIRTH 2096
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2275-2668 3.06e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 3.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2275 PPADTPRSPGHQLSVHSSESDVLRSPAAGNPAAGSPGA-AVQDSSVGLPPAVAQLNPQPAARisssvSPHPDSQDQKQQI 2353
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDpRGPAPPSPLPPDTHAPDPPPPSP-----SPAANEPDPHPPP 2644

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2354 ILQPPPGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVTAGLTYSTFVPIQAGPMQLTIPAVSVIHRTVGTSGDTI 2433
Cdd:PHA03247 2645 TVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPG 2724

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2434 TEASGAPNRPTGVAELSSVVPCIPIgqihVPGLQNlsPPALQSLTSLGMETvnlvglANATVGPQGHPPGLALNAVGLQV 2513
Cdd:PHA03247 2725 PAAARQASPALPAAPAPPAVPAGPA----TPGGPA--RPARPPTTAGPPAP------APPAAPAAGPPRRLTRPAVASLS 2792

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2514 LANAPAQSSPAPPAHIQGLQILNIALPTLIPSVGPVAVGTTGTPETTAPNSKAMELQMPAGQGHSAEPP---QGSPEGPQ 2590
Cdd:PHA03247 2793 ESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrRPPSRSPA 2872

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117938312 2591 ETPQTVSGPSADH-ARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPTPEALQKVATSAPPSLPTDRAAPRPPVPHRQP 2668
Cdd:PHA03247 2873 AKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2269-2660 2.10e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 2.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2269 DEHEQAPPADTPRSPGHQLSVHSSESDVLRSPAAGNPAAG---------SPGAAVQDSSVGLPPAVAQLNPqPAARISSS 2339
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarRLGRAAQASSPPQRPRRRAARP-TVGSLTSL 2698

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2340 VSPHPDSQDQkqqiilQPPPGLPSPQTHLFSHLPLHSQQQSRTPYNMVP--VGGIHVVTAGLTYSTFVPIQAGPMQLTIP 2417
Cdd:PHA03247 2699 ADPPPPPPTP------EPAPHALVSATPLPPGPAAARQASPALPAAPAPpaVPAGPATPGGPARPARPPTTAGPPAPAPP 2772

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2418 AVSVihrtvGTSGDTITEASGAPNRPTGVAELSSVVPCIPigQIHVPGLQNLSPPALQSLTSLGMETVNLVGLANATVGP 2497
Cdd:PHA03247 2773 AAPA-----AGPPRRLTRPAVASLSESRESLPSPWDPADP--PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2498 QghPPGLALN---AVGLQVLANAPAQSSPAPPAHIQGLQILNIALPTLIPSVGPVAVGTTG-----TPETTAPNSKAMEL 2569
Cdd:PHA03247 2846 P--PPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQperppQPQAPPPPQPQPQP 2923

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2570 QMPAgQGHSAEPPQGSPEGP-QETPQTVSGPSADHARPEdstkmdtkkgPSAGHVLPGRSPAQAQPAPTPEALQKVATSA 2648
Cdd:PHA03247 2924 PPPP-QPQPPPPPPPRPQPPlAPTTDPAGAGEPSGAVPQ----------PWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992

                         410
                  ....*....|..
gi 117938312 2649 PPSlPTDRAAPR 2660
Cdd:PHA03247 2993 TPP-LTGHSLSR 3003
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2293-2668 1.80e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 53.84  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2293 ESDVLRSPAAGNPAAGSPGAAVQDSSVGLPPAVAQLNPQPAARISSSVSPHPDSQDQkqqiilQPPPGLPSPQTHLFSHL 2372
Cdd:PRK07764  382 ERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPA------PAPPSPAGNAPAGGAPS 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2373 PLHSQQQSRTPynmvpvggihvvtagltystfVPIQAGPMQLTIPAvsvihrtvgtsgdtitEASGAPNRPTGVAELSSV 2452
Cdd:PRK07764  456 PPPAAAPSAQP---------------------APAPAAAPEPTAAP----------------APAPPAAPAPAAAPAAPA 498

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2453 VPCIPIGQIHVPGLQNLSPPALQSLTSLGMETVNLVgLANATVGPQ-------GHPPGLALNAVGLQ----VLANAPAQs 2521
Cdd:PRK07764  499 APAAPAGADDAATLRERWPEILAAVPKRSRKTWAIL-LPEATVLGVrgdtlvlGFSTGGLARRFASPgnaeVLVTALAE- 576

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2522 spappahiqglqILNIAL-PTLIPSVGPVAVGTTGTPETTAPNSKAMELQmPAGQGHSAEPPQGSPEGPQETPQTVSGPS 2600
Cdd:PRK07764  577 ------------ELGGDWqVEAVVGPAPGAAGGEGPPAPASSGPPEEAAR-PAAPAAPAAPAAPAPAGAAAAPAEASAAP 643

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117938312 2601 A-DHARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPTPEALQKVATSAPPSLPTDRAAPRPPVPHRQP 2668
Cdd:PRK07764  644 ApGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG 712
zf-H2C2_2 pfam13465
Zinc-finger double domain;
2088-2113 1.04e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.04e-05
                           10        20
                   ....*....|....*....|....*.
gi 117938312  2088 MLKKHIRTHTDVRPYHCSYCNFSFKT 2113
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2298-2668 2.14e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2298 RSPAAGNPAAGSPGAAvqdSSVGLPPAvAQLNPQPAARISSSVSPHPDSQDQKQQ-IILQPPPGLPSPQTHLFSHLPLHS 2376
Cdd:PRK07764  384 RLGVAGGAGAPAAAAP---SAAAAAPA-AAPAPAAAAPAAAAAPAPAAAPQPAPApAPAPAPPSPAGNAPAGGAPSPPPA 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2377 QQQSRTPynmVPVGGIHVVTAGLTYSTFVPIQAG------PMQLTIPAVSVIHRTVGTSGDTITEASGAPNRPTGVAELS 2450
Cdd:PRK07764  460 AAPSAQP---APAPAAAPEPTAAPAPAPPAAPAPaaapaaPAAPAAPAGADDAATLRERWPEILAAVPKRSRKTWAILLP 536

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2451 SVVPCIPIGQI-----HVPGLQNL--SPPALQSLTSLGMETVNLVGLANATVGPQGHPPGLAlNAVGLQVLANAPAQSSP 2523
Cdd:PRK07764  537 EATVLGVRGDTlvlgfSTGGLARRfaSPGNAEVLVTALAEELGGDWQVEAVVGPAPGAAGGE-GPPAPASSGPPEEAARP 615

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2524 APPAHiqglqilnialPTliPSVGPVAVGTTGTPETTAPNSKAMELQMPAGQGHSAEPPQGSPEGPQETPQTVSGPSADH 2603
Cdd:PRK07764  616 AAPAA-----------PA--APAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPP 682

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117938312 2604 ARPED--STKMDTKKGPSAGHVLPGRSPAQAQPAPTPEALQKVATSAPPSLPTDRAAPRPPVPHRQP 2668
Cdd:PRK07764  683 PAPAPaaPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPP 749
zf-H2C2_2 pfam13465
Zinc-finger double domain;
422-446 8.61e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 8.61e-05
                           10        20
                   ....*....|....*....|....*
gi 117938312   422 LLKHIRSHTGERPYPCVTCGFSFKT 446
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2297-2664 1.51e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2297 LRSPAAGNPAAGSPGA---AVQDSSVGlPPAVAQLNPQPAARISS---SVSPHPDS----QDQKQQIILQPPPGLPSPQT 2366
Cdd:PHA03247 2543 LASDDAGDPPPPLPPAappAAPDRSVP-PPRPAPRPSEPAVTSRArrpDAPPQSARprapVDDRGDPRGPAPPSPLPPDT 2621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2367 HlfshlPLHSQQQSRTPYNMVPVGGIHVVTagltystfvPIQAGPMQLTIPAVSVIHRTVGTSGDTiTEASGAPNRPTGV 2446
Cdd:PHA03247 2622 H-----APDPPPPSPSPAANEPDPHPPPTV---------PPPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRRR 2686

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2447 AelssvvpcipigqihvpglqnlSPPALQSLTSLgmetvnlvglanATVGPQGHPP----GLALNAVGLQVLANAPAQSS 2522
Cdd:PHA03247 2687 A----------------------ARPTVGSLTSL------------ADPPPPPPTPepapHALVSATPLPPGPAAARQAS 2732

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2523 PAPPAHiqglqilNIALPTLIPSVGPVAVGTTGTPETTAPNSkamelqmpagqghSAEPPQGSPEGPQETPQTVSGPSAD 2602
Cdd:PHA03247 2733 PALPAA-------PAPPAVPAGPATPGGPARPARPPTTAGPP-------------APAPPAAPAAGPPRRLTRPAVASLS 2792

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117938312 2603 HARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPtpealqkvaTSAPPSLPTDRAAPRPPVP 2664
Cdd:PHA03247 2793 ESRESLPSPWDPADPPAAVLAPAAALPPAASPAG---------PLPPPTSAQPTAPPPPPGP 2845
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 2074-2096 2.16e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 2.16e-04
                           10        20
                   ....*....|....*....|...
gi 117938312  2074 YICEECGIRCKKPSMLKKHIRTH 2096
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2497-2662 4.08e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2497 PQGHPPGLALNAVGLQVLANAPAQSSPAP---PAHIQGLQILNIALPTLIPSVGPVAVGTTGTPETTAPNSKAMELQMPA 2573
Cdd:PRK12323  402 PPAAPAAAPAAAAAARAVAAAPARRSPAPealAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPA 481

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2574 GQGHSAEPPQGSPEGP--QETPQTVSGPSADharpedstkmDTKKGPSAGHVLPGRSPAQAQPAPTPEALQKVATSAP-- 2649
Cdd:PRK12323  482 RAAPAAAPAPADDDPPpwEELPPEFASPAPA----------QPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPap 551

                         170
                  ....*....|....*
gi 117938312 2650 --PSLPTDRAAPRPP 2662
Cdd:PRK12323  552 raAAATEPVVAPRPP 566
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2260-2664 4.20e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 4.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2260 AKARQSTEKDEHEQAPPADTPRSPGHQLSVHSSESDvlrspaagNPAAGSPGAAVQDSSVGLPPAVAQLNPQPAARISSS 2339
Cdd:pfam03154   80 AKRQREKGASDTEEPERATAKKSKTQEISRPNSPSE--------GEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSP 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2340 VSPHPDSQDQKQQIILQPPPGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVTAGLTYSTFVPIQAgpmQLTIPAV 2419
Cdd:pfam03154  152 QDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT---QSTAAPH 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2420 SVIHRTVGTSGDTITeASGAPNRPTGVAELSSVVPCIPIGQIHVPGLQNLSPPALQSLTSLGMETVNLVGLANATVGPQG 2499
Cdd:pfam03154  229 TLIQQTPTLHPQRLP-SPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQS 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2500 H---PPGLALNAVGLQVLANAPAQSSPAP--PAHIQGLQILNIALPTLIPSvgpvavgttgtPETTAPnskamelQMPAG 2574
Cdd:pfam03154  308 QvppGPSPAAPGQSQQRIHTPPSQSQLQSqqPPREQPLPPAPLSMPHIKPP-----------PTTPIP-------QLPNP 369

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312  2575 QGHSaEPPQGSPEGPQETPQTVSGPSADHARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPTP-----EALQKVATSAP 2649
Cdd:pfam03154  370 QSHK-HPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPvltqsQSLPPPAASHP 448

                          410
                   ....*....|....*
gi 117938312  2650 PSLPTDRAAPRPPVP 2664
Cdd:pfam03154  449 PTSGLHQVPSQSPFP 463
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 2102-2123 7.49e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 7.49e-04
                           10        20
                   ....*....|....*....|..
gi 117938312  2102 YHCSYCNFSFKTKGNLTKHMKS 2123
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRT 22
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 2099-2130 1.08e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.77  E-value: 1.08e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 117938312   2099 VRPYHCSYCNFSFKTKGNLTKHMKSKAHSKKC 2130
Cdd:smart00451    1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
2491-2668 1.13e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.46  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2491 ANATVGPQGHPPGLALNAVGLQVLANAPAQSSPAPPAHIQglqilnialptlipsvgPVAVGTTGTPETTAPNSKAMELQ 2570
Cdd:PRK07003  392 GASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPA-----------------PPATADRGDDAADGDAPVPAKAN 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2571 MPAGqghSAEPPQGSPEGPQETPQTVSGPSADhaRPEDSTKMDTkkgPSAGHVLPGRSPAQAQPAPtPEALQKVATSAPP 2650
Cdd:PRK07003  455 ARAS---ADSRCDERDAQPPADSGSASAPASD--APPDAAFEPA---PRAAAPSAATPAAVPDARA-PAAASREDAPAAA 525

                         170
                  ....*....|....*...
gi 117938312 2651 SLPTDRAAPRPPVPHRQP 2668
Cdd:PRK07003  526 APPAPEARPPTPAAAAPA 543
ZnF_C2H2 smart00355
zinc finger;
2102-2123 2.41e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 37.45  E-value: 2.41e-03
                            10        20
                    ....*....|....*....|..
gi 117938312   2102 YHCSYCNFSFKTKGNLTKHMKS 2123
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRT 22
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 2272-2390 3.35e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.78  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2272 EQAPPADTPRSPGHQLSVhssesdVLRSPAAGNPAAGSPGAAVQDSSVGLPPAVAQLNPQPAARISSSVSPHPDSQDQKQ 2351
Cdd:PRK14951  385 EAAAPAAAPVAQAAAAPA------PAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPE 458

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 117938312 2352 QIIL----QPPPGLPSPQthlfshlPLHSQQQSRTPYNMVPVG 2390
Cdd:PRK14951  459 TVAIpvrvAPEPAVASAA-------PAPAAAPAAARLTPTEEG 494
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 2102-2167 4.20e-03

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 38.81  E-value: 4.20e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117938312  2102 YHCSYCNFSFKTKGNLTKHMKSKAHSKkcvdlgvsvglIDEQDTEESDEKQRFgcersgYDLEESD 2167
Cdd:pfam12756   50 NECLYCGKQFKSLEALRQHMRDKGHCK-----------IPYESEEEWLEIAEF------YDFSSSY 98
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2493-2664 4.64e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2493 ATVGPQGHPPGLALNAVGLQVLANAPAQSSPAPPAHIQGLQilniALPTLIPSVGPVAVGTTGTPETTAPNSKAmelqmP 2572
Cdd:PRK07764  627 PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD----GWPAKAGGAAPAAPPPAPAPAAPAAPAGA-----A 697

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2573 AGQGHSAEPPQGSPEGPQETPQTVSGPSADHARPEDSTKMDTKKgPSAGHVLPGRSPAQAQPAPTPEALQKVATSAPPSl 2652
Cdd:PRK07764  698 PAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL-PPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPP- 775

                         170
                  ....*....|..
gi 117938312 2653 PTDRAAPRPPVP 2664
Cdd:PRK07764  776 PSPPSEEEEMAE 787
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2511-2668 5.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2511 LQVLANAPAQS----SPAPPAHIqglqilnialptliPSVGPVAVGTTGTPETTAPNSKAMELQMPAGQGHSAEPPQGSP 2586
Cdd:PRK12323  358 LRMLAFRPGQSgggaGPATAAAA--------------PVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAP 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938312 2587 EGPQETPQTVSGpsadhARPEDSTKMDTKKGPSAGhvlPGRSPAQAQPAPTPEALQKVATSAPPSLPTDRAAPRPPVPHR 2666
Cdd:PRK12323  424 ARRSPAPEALAA-----ARQASARGPGGAPAPAPA---PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDD 495


                  ..
gi 117938312 2667 QP 2668
Cdd:PRK12323  496 PP 497
ZnF_C2H2 smart00355
zinc finger;
435-457 6.96e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 6.96e-03
                            10        20
                    ....*....|....*....|...
gi 117938312    435 YPCVTCGFSFKTKSNLYKHKKSH 457
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
2074-2096 9.44e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 9.44e-03
                            10        20
                    ....*....|....*....|...
gi 117938312   2074 YICEECGIRCKKPSMLKKHIRTH 2096
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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