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    Wsb2 WD repeat and SOCS box-containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 59043, updated on 9-May-2024

    Summary

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    Official Symbol
    Wsb2provided by MGI
    Official Full Name
    WD repeat and SOCS box-containing 2provided by MGI
    Primary source
    MGI:MGI:2144041
    See related
    Ensembl:ENSMUSG00000029364 AllianceGenome:MGI:2144041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Swip2; WSB-2
    Summary
    Predicted to be involved in intracellular signal transduction. Is expressed in several structures, including central nervous system; gonad; lung; stomach; and urinary system. Orthologous to human WSB2 (WD repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 87.6), cortex adult (RPKM 80.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 56.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117495370..117516666)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117357305..117378601)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene 60S ribosomal protein L27a pseudogene Neighboring gene STARR-seq mESC enhancer starr_14176 Neighboring gene predicted gene, 42012 Neighboring gene replication factor C (activator 1) 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:117838823-117838932 Neighboring gene STARR-positive B cell enhancer ABC_E6370 Neighboring gene STARR-seq mESC enhancer starr_14179 Neighboring gene predicted gene 15728

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of Wsb2 in the developing and adult mouse testis. Sarraj MA, et al. Reproduction, 2007 Apr. PMID 17504919
    2. SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. Vasiliauskas D, et al. Mech Dev, 1999 Apr. PMID 10354473
    3. Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling. Erkeland SJ, et al. Oncogene, 2007 Mar 29. PMID 17001306
    4. Twenty proteins containing a C-terminal SOCS box form five structural classes. Hilton DJ, et al. Proc Natl Acad Sci U S A, 1998 Jan 6. PMID 9419338, Free PMC Article
    5. WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Pashkova N, et al. Mol Cell, 2010 Nov 12. PMID 21070969, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wsb-2 binding to the G-CSF-R reduced its cell surface expression and inhibited proliferation signaling.
      Title: Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat and SOCS box-containing protein 2
    Names
    SOCS box-containing WD protein SWiP-2
    WD-40-repeat-containing protein with a SOCS box 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021539.5 → NP_067514.2  WD repeat and SOCS box-containing protein 2

      See identical proteins and their annotated locations for NP_067514.2

      Status: VALIDATED

      Source sequence(s)
      AC110234, AC113299
      Consensus CDS
      CCDS19604.1
      UniProtKB/Swiss-Prot
      O54929, Q6GTI7, Q9R1M8
      UniProtKB/TrEMBL
      E9Q8J9
      Related
      ENSMUSP00000031309.10, ENSMUST00000031309.16
      Conserved Domains (4) summary
      cd00200
      Location:121 → 360
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd03733
      Location:364 → 402
      SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
      sd00039
      Location:157 → 195
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:30 → 182
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      117495370..117516666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254744.2 → XP_030110604.1  WD repeat and SOCS box-containing protein 2 isoform X1

      Conserved Domains (3) summary
      cd03733
      Location:154 → 192
      SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
      sd00039
      Location:32 → 73
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:1 → 150
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54929.2 GenPept UniProtKB/Swiss-Prot:O54929

    Gene LinkOut

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