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Conserved domains on  [gi|31982686|ref|NP_067514|]
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WD repeat and SOCS box-containing protein 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 1.02e-63

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 1.02e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  30 WSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSRSskndpkgrgslkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL--WDLATGLLLRTLTGHTGA---------------------VRSVAFSP-------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 110 lwarhhpqapdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 131 ------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 270 TGERLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGLCC-TFFPHGGI 347
Cdd:COG2319 277 TGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKT 344

                       330
                ....*....|...
gi 31982686 348 IATGTRDGHVQFW 360
Cdd:COG2319 345 LASGSDDGTVRLW 357
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 364-402 4.02e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239702  Cd Length: 39  Bit Score: 82.86  E-value: 4.02e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 31982686 364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 1.02e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 1.02e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  30 WSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSRSskndpkgrgslkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL--WDLATGLLLRTLTGHTGA---------------------VRSVAFSP-------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 110 lwarhhpqapdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 131 ------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 270 TGERLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGLCC-TFFPHGGI 347
Cdd:COG2319 277 TGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKT 344

                       330
                ....*....|...
gi 31982686 348 IATGTRDGHVQFW 360
Cdd:COG2319 345 LASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-360 6.86e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.92  E-value: 6.86e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 121 VSCL-------ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQIQVL 193
Cdd:cd00200  12 VTCVafspdgkLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 194 SGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGER 273
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 274 LRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGL-CCTFFPHGGIIATG 351
Cdd:cd00200 170 VATLTG------------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASG 237


                ....*....
gi 31982686 352 TRDGHVQFW 360
Cdd:cd00200 238 SEDGTIRVW 246
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 364-402 4.02e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 82.86  E-value: 4.02e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 31982686 364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 360-402 1.47e-12

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 61.54  E-value: 1.47e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 31982686    360 WTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
PTZ00421 PTZ00421
coronin; Provisional
 126-267 7.89e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.29  E-value: 7.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  126 LATGLNDGQIKIWEVQT-GLL------LLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQ 198
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeGLTqnisdpIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSD 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31982686  199 WVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS-CDFSPDSALLVTASYDTS----VIMWD 267
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWD 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 7.92e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 7.92e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 31982686    228 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
230-267 1.25e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.25e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 31982686   230 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 267
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 368-400 2.67e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.00  E-value: 2.67e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 31982686   368 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLT 400
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 1.02e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 1.02e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  30 WSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSRSskndpkgrgslkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL--WDLATGLLLRTLTGHTGA---------------------VRSVAFSP-------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 110 lwarhhpqapdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 131 ------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 270 TGERLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGLCC-TFFPHGGI 347
Cdd:COG2319 277 TGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKT 344

                       330
                ....*....|...
gi 31982686 348 IATGTRDGHVQFW 360
Cdd:COG2319 345 LASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
10-360 1.03e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.07  E-value: 1.03e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  10 LAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCVVKLvpWPLEeqfipkgfeaksrssknDPKGRGSLKEKTld 89
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--WDLA-----------------TGKLLRTLTGHS-- 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  90 cgQIVWGLAFSPWpsppSRklwarhhpqapdvsclILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiL 169
Cdd:COG2319 163 --GAVTSVAFSPD----GK----------------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-L 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 170 VSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSP 249
Cdd:COG2319 220 ASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 250 DSALLVTASYDTSVIMWDPYTGERLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA 329
Cdd:COG2319 299 DGKLLASGSDDGTVRLWDLATGKLLRTLTG------------HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                       330       340       350
                ....*....|....*....|....*....|...
gi 31982686 330 FAPMTNG--LCCTFFPHGGIIATGTRDGHVQFW 360
Cdd:COG2319 367 TLTGHTGavTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
125-370 1.05e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 1.05e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 125 ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCS 204
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVA 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 205 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHtqlep 284
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG----- 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 285 tmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGIIATGTRDGHVQFWTA 362
Cdd:COG2319 245 -------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                       250
                ....*....|
gi 31982686 363 --PRVLSSLK 370
Cdd:COG2319 318 atGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-360 6.86e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.92  E-value: 6.86e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 121 VSCL-------ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQIQVL 193
Cdd:cd00200  12 VTCVafspdgkLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 194 SGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGER 273
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 274 LRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGL-CCTFFPHGGIIATG 351
Cdd:cd00200 170 VATLTG------------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASG 237


                ....*....
gi 31982686 352 TRDGHVQFW 360
Cdd:cd00200 238 SEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-360 4.10e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 173.29  E-value: 4.10e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSI 205
Cdd:cd00200  66 LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAF 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 206 SPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHhtqlept 285
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR------- 216

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31982686 286 mddsdVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGIIATGTRDGHVQFW 360
Cdd:cd00200 217 -----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNsvTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 120-321 1.23e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 1.23e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 120 DVSCL-------ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLIlVSASRDKTLRIWDLNKhGKQIQV 192
Cdd:cd00200  95 YVSSVafspdgrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDGTIKLWDLRT-GKCVAT 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 193 LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGE 272
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 31982686 273 RLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWA 321
Cdd:cd00200 253 CVQTLSG------------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
124-371 3.18e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.54  E-value: 3.18e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 124 LILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCC 203
Cdd:COG2319  49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSV 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 204 SISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLhhtqle 283
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL------ 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 284 ptmddsDVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGIIATGTRDGHVQFW- 360
Cdd:COG2319 201 ------TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWd 274

                       250
                ....*....|..
gi 31982686 361 -TAPRVLSSLKH 371
Cdd:COG2319 275 lATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
30-270 1.65e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.92  E-value: 1.65e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  30 WSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSRSskndpkgrgslkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRL--WDLATGKLLRTLTGHSGS---------------------VRSVAFSP-------- 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 110 lwarhhpqapdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 257 ------------DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 322

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402


                .
gi 31982686 270 T 270
Cdd:COG2319 403 T 403
WD40 COG2319
WD40 repeat [General function prediction only];
126-371 1.47e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 1.47e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGsLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSI 205
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDG-ARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 206 SPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHtqlept 285
Cdd:COG2319  87 SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG------ 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 286 mddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGL-CCTFFPHGGIIATGTRDGHVQFW--T 361
Cdd:COG2319 161 ------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVrSVAFSPDGKLLASGSADGTVRLWdlA 234

                       250
                ....*....|
gi 31982686 362 APRVLSSLKH 371
Cdd:COG2319 235 TGKLLRTLTG 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-360 1.28e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.50  E-value: 1.28e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 269
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 270 TGERLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGI 347
Cdd:cd00200  82 TGECVRTLTG------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvNSVAFSPDGTF 149

                       170
                ....*....|...
gi 31982686 348 IATGTRDGHVQFW 360
Cdd:cd00200 150 VASSSQDGTIKLW 162
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 364-402 4.02e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 82.86  E-value: 4.02e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 31982686 364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 364-402 4.75e-20

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 82.64  E-value: 4.75e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 31982686 364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03745   1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 231-360 8.98e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 8.98e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 231 LIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHhtqleptmddsdVHMSSLRSVCFSPEGLYLAT 310
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK------------GHTGPVRDVAASADGTYLAS 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 31982686 311 VADDRLLRIWALELKAPVA-FAPMTNG-LCCTFFPHGGIIATGTRDGHVQFW 360
Cdd:cd00200  69 GSSDKTIRLWDLETGECVRtLTGHTSYvSSVAFSPDGRILSSSSRDKTIKVW 120
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 360-402 1.47e-12

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 61.54  E-value: 1.47e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 31982686    360 WTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 364-403 4.82e-12

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 60.21  E-value: 4.82e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 31982686 364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRT 403
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-182 4.66e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 4.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  30 WSVAFSPDGSWFAWSQGHCVVKLvpWPLEEQFIPKGFEAKSrsskndpkgrgslkektldcgQIVWGLAFSPWPsppsrk 109
Cdd:cd00200 181 NSVAFSPDGEKLLSSSSDGTIKL--WDLSTGKCLGTLRGHE---------------------NGVNSVAFSPDG------ 231

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31982686 110 lwarhhpqapdvscLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWD 182
Cdd:cd00200 232 --------------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 126-267 7.89e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.29  E-value: 7.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  126 LATGLNDGQIKIWEVQT-GLL------LLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQ 198
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeGLTqnisdpIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSD 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31982686  199 WVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS-CDFSPDSALLVTASYDTS----VIMWD 267
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWD 243
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 368-402 1.01e-08

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 50.55  E-value: 1.01e-08
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 31982686 368 SLKHLCRKALRSFL---TTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03587   4 SLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 7.92e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 7.92e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 31982686    228 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
230-267 1.25e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.25e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 31982686   230 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 267
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 367-402 2.86e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 46.44  E-value: 2.86e-07
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 31982686 367 SSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03717   4 RSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 132-267 4.25e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 4.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  132 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQwvYCCSISPDCS- 210
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQ-GVSIGTIKTKAN--ICCVQFPSESg 630

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982686  211 -MLCSAAGEKSVFLWSMRSYTL-IRKLEGHQSSVVSCDFSpDSALLVTASYDTSVIMWD 267
Cdd:PLN00181 631 rSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD 688
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 367-402 4.56e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.86  E-value: 4.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 31982686    367 SSLKHLCRKALRSFLttYQVLALPIPKKMKEFLTYR 402
Cdd:smart00969   1 RSLQHLCRLAIRRSL--GGIDKLPLPPRLKDYLLYY 34
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-182 5.15e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 31982686    142 TGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWD 182
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 138-226 1.40e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  138 WEVQTGLLL--------------LNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQ-------VLSGH 196
Cdd:PTZ00420  45 WEVEGGGLIgairlenqmrkppvIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGH 124

                         90       100       110
                 ....*....|....*....|....*....|.
gi 31982686  197 LQWVYCCSISP-DCSMLCSAAGEKSVFLWSM 226
Cdd:PTZ00420 125 KKKISIIDWNPmNYYIMCSSGFDSFVNIWDI 155
WD40 pfam00400
WD domain, G-beta repeat;
143-182 1.71e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.71e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 31982686   143 GLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWD 182
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 115-304 3.28e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  115 HPQAPDVscliLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDlNKHGKQIQVLS 194
Cdd:PTZ00421 134 HPSAMNV----LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSL-LCTTSKDKKLNIID-PRDGTIVSSVE 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  195 GHL-----QWVYCCSISPDCSMLCSAAGEKSVFLWSmrsytlIRKLEG-------HQSSVVSCD-FSPDSALLVTASYDT 261
Cdd:PTZ00421 208 AHAsaksqRCLWAKRKDLIITLGCSKSQQRQIMLWD------TRKMASpystvdlDQSSALFIPfFDEDTNLLYIGSKGE 281

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 31982686  262 SVIMWDPYTGERLRSLHhtqlepTMDDSDVHmsslRSVCFSPE 304
Cdd:PTZ00421 282 GNIRCFELMNERLTFCS------SYSSVEPH----KGLCMMPK 314
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 187-225 8.27e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 8.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31982686    187 GKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWS 225
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 368-400 2.67e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.00  E-value: 2.67e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 31982686   368 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLT 400
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
WD40 pfam00400
WD domain, G-beta repeat;
187-225 3.10e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 31982686   187 GKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWS 225
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 368-402 9.14e-05

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 39.40  E-value: 9.14e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 31982686 368 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLTYR 402
Cdd:cd03716   5 SLQHLCRLAIRRCLGRRrleLIKKLPLPPRLKDYLLYE 42
PTZ00421 PTZ00421
coronin; Provisional
 149-268 3.34e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  149 LSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQ------IQVLSGHLQWVYCCSISPDC-SMLCSAAGEKSV 221
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTqnisdpIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVV 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 31982686  222 FLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDP 268
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDP 197
PTZ00420 PTZ00420
coronin; Provisional
 125-199 5.08e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686  125 ILATGLNDGQIKIWE----------VQTGLLLLNlsGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQV-- 192
Cdd:PTZ00420  89 ILASGSEDLTIRVWEiphndesvkeIKDPQCILK--GHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQInm 166

                         90
                 ....*....|
gi 31982686  193 ---LSGhLQW 199
Cdd:PTZ00420 167 pkkLSS-LKW 175
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-320 8.07e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 8.07e-04
                           10        20
                   ....*....|....*....|....*....
gi 31982686    292 HMSSLRSVCFSPEGLYLATVADDRLLRIW 320
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 125-261 9.26e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.66  E-value: 9.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982686 125 ILATGLNDGQIKIWEVQ-TGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCC 203
Cdd:COG0823   1 LAFTLSRDGNSDIYVVDlDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31982686 204 SISPDCSMLCSAAGEKSVF-LWSMRsytlirkLEGHQSSVVSCD-----FSPDSALLVTASYDT 261
Cdd:COG0823  81 SWSPDGKRLAFVSRSDGRFdIYVLD-------LDGGAPRRLTDGpgspsWSPDGRRIVFSSDRG 137
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 368-404 3.40e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 35.21  E-value: 3.40e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 31982686 368 SLKHLCRKALRSflTTYQVLALPIPKKMKEFLTYRTF 404
Cdd:cd03736   5 SLQHLCRITINK--CTRQIQELPLPTRLKDYLTEYTY 39
WD40 pfam00400
WD domain, G-beta repeat;
292-320 4.73e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.73e-03
                          10        20
                  ....*....|....*....|....*....
gi 31982686   292 HMSSLRSVCFSPEGLYLATVADDRLLRIW 320
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 368-399 6.31e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 34.32  E-value: 6.31e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 31982686 368 SLKHLCRKALRSFLTTYQVLALPIPKKMKEFL 399
Cdd:cd03740   5 SLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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