Rabep1 rabaptin, RAB GTPase binding effector protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rabep1provided by RGD
Official Full Name: rabaptin, RAB GTPase binding effector protein 1provided by RGD
Primary source: RGD:708568
See related: Ensembl:ENSRNOG00000005015 AllianceGenome:RGD:708568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein domain specific binding activity and protein homodimerization activity. Predicted to be involved in Golgi to plasma membrane transport and protein localization to ciliary membrane. Predicted to be located in early endosome and recycling endosome. Predicted to be part of protein-containing complex. Predicted to be active in endocytic vesicle and endosome. Orthologous to human RABEP1 (rabaptin, RAB GTPase binding effector protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 248.6), Liver (RPKM 125.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (56064742..56168778)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55566156..55667595)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (57462272..57579901)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in protein localization to ciliary membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to ciliary membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to ciliary membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab GTPase-binding effector protein 1

Names: rabaptin-5; rabaptin-5alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019124.2 → NP_061997.2 rab GTPase-binding effector protein 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O35550, P70609

UniProtKB/TrEMBL

A6HGA2

Related

ENSRNOP00000050017.4, ENSRNOT00000041443.4

Conserved Domains (2) summary

pfam03528
Location:9 → 495

Rabaptin

pfam09311
Location:533 → 839

Rab5-bind; Rabaptin-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

56064742..56168778

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269681.1 → XP_063125751.1 rab GTPase-binding effector protein 1 isoform X1
XM_006246795.5 → XP_006246857.1 rab GTPase-binding effector protein 1 isoform X2

UniProtKB/Swiss-Prot

O35550, P70609

Conserved Domains (3) summary

pfam03528
Location:9 → 495

Rabaptin; Rabaptin

pfam09311
Location:518 → 804

Rab5-bind; Rabaptin-like protein

pfam10267
Location:613 → 749

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
XM_063269682.1 → XP_063125752.1 rab GTPase-binding effector protein 1 isoform X3
XM_006246796.5 → XP_006246858.1 rab GTPase-binding effector protein 1 isoform X4

UniProtKB/Swiss-Prot

O35550, P70609

Conserved Domains (2) summary

pfam03528
Location:9 → 495

Rabaptin; Rabaptin

pfam10267
Location:574 → 710

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
XM_008767861.4 → XP_008766083.1 rab GTPase-binding effector protein 1 isoform X5

See identical proteins and their annotated locations for XP_008766083.1

UniProtKB/TrEMBL

A0A8I5ZKK4, A6HGA4, A6HGA5

Conserved Domains (3) summary

pfam03528
Location:1 → 411

Rabaptin; Rabaptin

pfam09311
Location:449 → 755

Rab5-bind; Rabaptin-like protein

pfam10267
Location:564 → 700

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein