Conserved Protein Domain Family
Rab5-bind
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pfam09311: Rab5-bind (this model, PSSM-Id:286404 is obsolete and has been replaced by 462752)
Rabaptin-like protein
Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes.
Links
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Statistics
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PSSM-Id: 286404
Aligned: 5 rows
Threshold Bit Score: 346.846
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O35550       533 CDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKEKQELEDFLRQSAEDSSHQISALVLRAQASEVLLEE 612 Norway rat
Q19088        37 CEMCQNYEVNLTALQENERKLKEEVKAAMELNERYQLDLSNERDYRKELEKKMNELSTNCLNQVNEAAKANAKSEQRLDE 116 Caenorhabditis ...
AAM80557      45 CEMCANYENGLQQYQETERRLRQQLTALQNLNERYKSELSAARLNHKELDSSVNEMMENVSKQLTDLRDIFKAVELRHTE 124 Trichinella spi...
XP_012812295 524 CDMCSNYEKQLQGIQTQEAEIRDQVKKLQSMLRQVNDQLEKTLKDKKDLEDYMKQNTEETSTQISTLTIRTNQSETLLAD 603 western clawed ...
XP_003971004 528 CDMCSNYEKQLQAIQGQEAETRDQVKKLQVMLRQANEQLERTMTDKQNLEDSVQAGNKETAAKVSTLLHRVQESETLLSS 607 torafugu

O35550       613 LQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQLAEDFILPDTVQVLRELVLKYRENIVHVR 692 Norway rat
Q19088       117 LSAKHDKSIEVFTDQLNLARDKLQQADDDFVTLGKKYKKLLGSTRKSAQELRSEKIDMPADLDQLQFICLKNREELIETR 196 Caenorhabditis ...
AAM80557     125 LEGYFKGETANIRRELSEVIASRRKIEDVYQTLSDQYDHLLGRHRQGARQLEEEKIDLPQDVEELQLLCLQLKEELIESR 204 Trichinella spi...
XP_012812295 604 LQQAFTQAKRNIQDQMAVLMHSREQVSEELLRLQRDNESLQGKHSLHVSLQQAENFSLPETSEELQNLVLKYREDIISVR 683 western clawed ...
XP_003971004 608 LQLAFSEAKRNTQENLMVLVKSREQVADELSRLQRDNESLQGKHKLHVELQQQEGFQMPDNVQELQELVVQLRDHLVALR 687 torafugu

O35550       693 TAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEI----ASISSLKAELERIKVEKGQlestlreKSQQ 768 Norway rat
Q19088       197 AAKEHTEQQLQDEITVLRAQILEERAHREDQEVTFTAEISRLQSEL----GKINTRMVVASETIADQDS-------NIRQ 265 Caenorhabditis ...
AAM80557     205 TVKEHLEETLMSEIVLLKAEIASEKQAKEEMEASLADDICHLRSQL----DC-------AQNCLLERESlykwkaeAQSQ 273 Trichinella spi...
XP_012812295 684 TAADHLEEKLKAEILFLKEQIQAEQCQKENIEETLQIEIENCKEEIdileASTSSLKLELDRVKAEREQleaslqeKTRA 763 western clawed ...
XP_003971004 688 TSFDHMEEKLKAEILFLKEQIQAEQCLKENLEDTLQVEIEGYKEEI----ASFSRLKTELEQIRVEKEQlqngvteKAEL 763 torafugu

O35550       769 LESLQEIKVNLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQAD 839 Norway rat
Q19088       266 IRDLQTTVGELETQVQQVQNERAAVEQTAQNYKQRCTSLQQELDTSEVVQRDFVKLSQSLQIQLEKIRQSE 336 Caenorhabditis elegans
AAM80557     274 FDKHRRRISELEANVKELEKDKLQAKELIQEGQRRAQVLQQELDNCVQVQRDFVKLSQSLQIQLEKIRQSE 344 Trichinella spiralis
XP_012812295 764 LQNLQTLKDSLEDQLKKETGGKASLEQLVFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQTD 834 western clawed frog
XP_003971004 764 LEKLQSMKISLEQQLKDLSDTKAALEAQVVDEKAKAQRLQTELDVSEQVQKDFVKLSQTLQVQLERIRQAD 834 torafugu
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