Tecta tectorin alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tectaprovided by MGI
Official Full Name: tectorin alphaprovided by MGI
Primary source: MGI:MGI:109575
See related: Ensembl:ENSMUSG00000037705 AllianceGenome:MGI:109575
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tctna
Summary: An extracellular matrix structural constituent. Predicted to be involved in cell-matrix adhesion. Predicted to act upstream of or within sensory perception of sound. Located in extracellular matrix. Is expressed in inner ear. Used to study autosomal dominant nonsyndromic deafness 12. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Orthologous to human TECTA (tectorin alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 2.7), CNS E14 (RPKM 0.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.1; 9 23.63 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (42240918..42312986, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (42329622..42401690, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The release of surface-anchored alpha-tectorin, an apical extracellular matrix protein, mediates tectorial membrane organization.
Title: The release of surface-anchored α-tectorin, an apical extracellular matrix protein, mediates tectorial membrane organization.
This study demonstrated that the Tecta(Y1870C/+) Mice Reflect Changes in Cochlear Amplification and How It Is Controlled by the Tectorial Membrane.
Title: Spontaneous Otoacoustic Emissions in Tecta(Y1870C/+) Mice Reflect Changes in Cochlear Amplification and How It Is Controlled by the Tectorial Membrane.
These results highlight the importance of the tectorin-based matrix and epithelial signals for precise collagen organisation in the tectorial membrane.
Title: A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane.
Alpha-tectorin and beta-tectorin crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus.
Title: Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus.
Tecta mutant mice all exhibit an enhanced tendency to have audiogenic seizures in response to white noise stimuli.
Title: Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane.
CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin and influences the physical properties of the tectorial membrane
Title: Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.
The morphology and mechanical properties of wild-type, heterozygous, and homozygous Tecta tecta membrane, were analysed.
Title: Structural and mechanical analysis of tectorial membrane Tecta mutants.
In Tecta(Y)(1870C/+) mice, the tectorin content of the tectorial membrane was reduced, as was the content of glycoconjugates reacting with the lectin wheat germ agglutinin.
Title: Tectorial membrane material properties in Tecta(Y)(1870C/+) heterozygous mice.
The Tecta (A349D/A349D) mouse reveals that missense mutations in Tecta can be recessive and lead to tectorial membrane detachment
Title: Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (8) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495427

Tecta (e-PCR), detects polymorphism
- UniSTS:256876

Tecta (e-PCR), detects polymorphism
- UniSTS:144600

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix structural constituent	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sound	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-tectorin

Names: [a]-tectorin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324548.2 → NP_001311477.1 alpha-tectorin isoform 2 preproprotein

Status: VALIDATED

Source sequence(s)

AC156631

Consensus CDS

CCDS85660.1

UniProtKB/TrEMBL

B7ZWA6

Related

ENSMUSP00000125370.2, ENSMUST00000160940.2

Conserved Domains (10) summary

smart00216
Location:703 → 865

VWD; von Willebrand factor (vWF) type D domain

smart00241
Location:1800 → 2054

ZP; Zona pellucida (ZP) domain

smart00539
Location:98 → 254

NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins

smart00832
Location:517 → 591

C8; This domain contains 8 conserved cysteine residues

pfam00094
Location:322 → 478

VWD; von Willebrand factor type D domain

pfam00100
Location:1932 → 2052

Zona_pellucida; Zona pellucida-like domain

pfam01826
Location:597 → 650

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:1298 → 1368

C8; C8 domain

pfam14670
Location:2084 → 2116

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl17735
Location:652 → 706

VWC; von Willebrand factor type C domain
NM_001378602.1 → NP_001365531.1 alpha-tectorin isoform 1 prepreprotein precursor

Status: VALIDATED

Source sequence(s)

AC156631

UniProtKB/Swiss-Prot

E9QNR3, O08523

UniProtKB/TrEMBL

B7ZWA6

Conserved Domains (9) summary

smart00216
Location:703 → 865

VWD; von Willebrand factor (vWF) type D domain

smart00241
Location:1805 → 2059

ZP; Zona pellucida (ZP) domain

smart00539
Location:98 → 254

NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins

smart00832
Location:517 → 591

C8; This domain contains 8 conserved cysteine residues

cl17735
Location:652 → 706

VWC; von Willebrand factor type C domain

pfam00094
Location:322 → 478

VWD; von Willebrand factor type D domain

pfam08742
Location:1300 → 1368

C8; C8 domain

pfam14670
Location:2089 → 2121

FXa_inhibition; Coagulation Factor Xa inhibitory site

cd19941
Location:597 → 650

TIL; trypsin inhibitor-like cysteine rich domain
NM_009347.4 → NP_033373.2 alpha-tectorin isoform 1 preproprotein

See identical proteins and their annotated locations for NP_033373.2

Status: VALIDATED

Source sequence(s)

AC156631

Consensus CDS

CCDS23087.1

UniProtKB/Swiss-Prot

E9QNR3, O08523

UniProtKB/TrEMBL

B7ZWA6

Related

ENSMUSP00000040262.8, ENSMUST00000042190.14

Conserved Domains (9) summary

smart00216
Location:703 → 865

VWD; von Willebrand factor (vWF) type D domain

smart00241
Location:1805 → 2059

ZP; Zona pellucida (ZP) domain

smart00539
Location:98 → 254

NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins

smart00832
Location:517 → 591

C8; This domain contains 8 conserved cysteine residues

cl17735
Location:652 → 706

VWC; von Willebrand factor type C domain

pfam00094
Location:322 → 478

VWD; von Willebrand factor type D domain

pfam08742
Location:1300 → 1368

C8; C8 domain

pfam14670
Location:2089 → 2121

FXa_inhibition; Coagulation Factor Xa inhibitory site

cd19941
Location:597 → 650

TIL; trypsin inhibitor-like cysteine rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

42240918..42312986 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154833.1 → XP_036010726.1 alpha-tectorin isoform X1

UniProtKB/TrEMBL

B7ZWA6

Conserved Domains (9) summary

smart00216
Location:676 → 838

VWD; von Willebrand factor (vWF) type D domain

smart00241
Location:1778 → 2032

ZP; Zona pellucida (ZP) domain

smart00539
Location:71 → 227

NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins

smart00832
Location:490 → 564

C8; This domain contains 8 conserved cysteine residues

cl17735
Location:625 → 679

VWC; von Willebrand factor type C domain

pfam00094
Location:295 → 451

VWD; von Willebrand factor type D domain

pfam08742
Location:1273 → 1341

C8; C8 domain

pfam14670
Location:2062 → 2094

FXa_inhibition; Coagulation Factor Xa inhibitory site

cd19941
Location:570 → 623

TIL; trypsin inhibitor-like cysteine rich domain
XM_006510152.3 → XP_006510215.1 alpha-tectorin isoform X2

UniProtKB/TrEMBL

B7ZWA6

Conserved Domains (7) summary

smart00216
Location:703 → 865

VWD; von Willebrand factor (vWF) type D domain

smart00539
Location:98 → 254

NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins

smart00832
Location:517 → 591

C8; This domain contains 8 conserved cysteine residues

cl17735
Location:652 → 706

VWC; von Willebrand factor type C domain

pfam00094
Location:322 → 476

VWD; von Willebrand factor type D domain

pfam01826
Location:597 → 650

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:1301 → 1368

C8; C8 domain