U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha [ Mus musculus (house mouse) ]

    Gene ID: 52551, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sgtaprovided by MGI
    Official Full Name
    small glutamine-rich tetratricopeptide repeat (TPR)-containing, alphaprovided by MGI
    Primary source
    MGI:MGI:1098703
    See related
    Ensembl:ENSMUSG00000004937 AllianceGenome:MGI:1098703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sgt; Stg; D10Ertd190e; 5330427H01Rik
    Summary
    Predicted to enable several functions, including BAT3 complex binding activity; protein dimerization activity; and protein self-association. Predicted to be involved in several processes, including establishment of protein localization to membrane; regulation of ER-associated ubiquitin-dependent protein catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to be located in cytosol and nucleus. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and skin. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 191.2), mammary gland adult (RPKM 106.5) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80879905..80896105, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81044071..81060271, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DIRAS family, GTP-binding RAS-like 1 Neighboring gene predicted gene 16099 Neighboring gene solute carrier family 39 (zinc transporter), member 3 Neighboring gene STARR-positive B cell enhancer ABC_E2952 Neighboring gene STARR-positive B cell enhancer ABC_E1808 Neighboring gene STARR-positive B cell enhancer ABC_E462 Neighboring gene thimet oligopeptidase 1 Neighboring gene cAMP responsive element binding protein 3-like 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice. Philp LK, et al. Sci Rep, 2016 Jun 30. PMID 27358191, Free PMC Article
    2. SGTA associates with intracellular aggregates in neurodegenerative diseases. Kubota S, et al. Mol Brain, 2021 Mar 23. PMID 33757575, Free PMC Article
    3. A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. Tobaben S, et al. J Biol Chem, 2003 Oct 3. PMID 12878599
    4. Binding of SGTA to Rpn13 selectively modulates protein quality control. Leznicki P, et al. J Cell Sci, 2015 Sep 1. PMID 26169395, Free PMC Article
    5. CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Sharma M, et al. Nat Cell Biol, 2011 Jan. PMID 21151134

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SGTA associates with intracellular aggregates in neurodegenerative diseases.
      Title: SGTA associates with intracellular aggregates in neurodegenerative diseases.
    2. In conclusion, this thorough investigation of SGTA-null mutation reports a mild phenotype of reduced body size.
      Title: Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice.
    3. the binding of SGTA to Rpn13 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation.
      Title: Binding of SGTA to Rpn13 selectively modulates protein quality control.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC6336

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BAT3 complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TRC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    small glutamine-rich tetratricopeptide repeat-containing protein alpha
    Names
    alpha-SGT
    small glutamine-rich tetratricopeptide repeat (TPR) containing protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358549.2 → NP_001345478.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC152500
      Consensus CDS
      CCDS35990.1
      UniProtKB/Swiss-Prot
      Q8BGA6, Q8BJU0, Q99L52
      Conserved Domains (3) summary
      sd00006
      Location:92 → 120
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerisation domain of SGTA
      cl26005
      Location:106 → 212
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    2. NM_001358550.2 → NP_001345479.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152500
      Consensus CDS
      CCDS88056.1
      UniProtKB/TrEMBL
      Q3TN35
      Related
      ENSMUSP00000151949.2, ENSMUST00000218208.2
      Conserved Domains (3) summary
      PLN03088
      Location:105 → 211
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:91 → 119
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerization domain of SGTA

    3. NM_001428937.1 → NP_001415866.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC152500

    4. NM_001428938.1 → NP_001415867.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152500

    5. NM_001428939.1 → NP_001415868.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152500

    6. NM_024499.3 → NP_078775.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1

      See identical proteins and their annotated locations for NP_078775.1

      Status: VALIDATED

      Source sequence(s)
      AC152500
      Consensus CDS
      CCDS35990.1
      UniProtKB/Swiss-Prot
      Q8BGA6, Q8BJU0, Q99L52
      Related
      ENSMUSP00000005067.6, ENSMUST00000005067.6
      Conserved Domains (3) summary
      sd00006
      Location:92 → 120
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerisation domain of SGTA
      cl26005
      Location:106 → 212
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    RNA

    1. NR_190542.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC152500

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80879905..80896105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513877.2 → XP_006513940.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

      UniProtKB/TrEMBL
      Q3TN35
      Conserved Domains (3) summary
      PLN03088
      Location:105 → 211
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:91 → 119
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerization domain of SGTA

    2. XM_030245176.2 → XP_030101036.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X2

      Conserved Domains (2) summary
      PLN03088
      Location:4 → 110
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:23 → 53
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJU0.2 GenPept UniProtKB/Swiss-Prot:Q8BJU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous