PLGLB1 plasminogen like B1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLGLB1provided by HGNC
Official Full Name: plasminogen like B1provided by HGNC
Primary source: HGNC:HGNC:9072
See related: Ensembl:ENSG00000183281 MIM:173340; AllianceGenome:HGNC:9072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PLGL; PRGB; PLGP1; PRP-B
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver (RPKM 64.1) and skin (RPKM 1.9) See more
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Genomic context

Location:: 2p11.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (87010224..87021844, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (87015434..87027063, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (87237347..87248967, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

D11S2560 (e-PCR)
- UniSTS:37928

D15S1477 (e-PCR)
- UniSTS:474482

NoName (e-PCR)
- UniSTS:487287

PLGL_8545 (e-PCR)
- UniSTS:467836

RH80030 (e-PCR)
- UniSTS:87680

A007H01 (e-PCR)
- UniSTS:81025

RH79781 (e-PCR)
- UniSTS:89765

D2S2643 (e-PCR)
- UniSTS:1206

RH65147 (e-PCR)
- UniSTS:91607

Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plasminogen-like protein B

Names: plasminogen-related protein B; type B plasminogen related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032392.4 → NP_001027564.1 plasminogen-like protein B precursor

See identical proteins and their annotated locations for NP_001027564.1

Status: VALIDATED

Source sequence(s)

AC111200, AC125232

Consensus CDS

CCDS33238.1

UniProtKB/Swiss-Prot

Q02325, Q15195, Q580R1

Related

ENSP00000347933.3, ENST00000355705.4

Conserved Domains (1) summary

cd01099
Location:22 → 96

PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...