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    PLGLA plasminogen like A (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 285189, updated on 10-Oct-2023

    Summary

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    Official Symbol
    PLGLAprovided by HGNC
    Official Full Name
    plasminogen like A (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:9074
    See related
    Ensembl:ENSG00000291125 MIM:612212; AllianceGenome:HGNC:9074
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRGA; PLGP2; PLGLA1
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver (RPKM 55.0) and kidney (RPKM 2.5) See more
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    Genomic context

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    Location:
    2q12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (106382114..106391395)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (106842876..106852158)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (106998570..107007851)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16340 Neighboring gene ILRUN pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11848 Neighboring gene ANAPC1 pseudogene 6 Neighboring gene RANBP2 like and GRIP domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:107056244-107056460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:107060799-107061300 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:107084140-107084332 Neighboring gene anaphase-promoting complex subunit 1-like Neighboring gene CD8B family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pseudogene PLGLA exerts anti-tumor effects on hepatocellular carcinoma through modulating miR-324-3p/GLYATL1 axis. Bao L, et al. Dig Liver Dis, 2022 Jul. PMID 34782279
    2. Homologous plasminogen N-terminal and plasminogen-related gene A and B peptides. Characterization of cDNAs and recombinant fusion proteins. Lewis VO, et al. Eur J Biochem, 1999 Feb. PMID 10092845
    3. Characterization of the 5'-flanking regions of plasminogen-related genes A and B. Kida M, et al. FEBS Lett, 1997 Mar 3. PMID 9074645
    4. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. Ichinose A. Biochemistry, 1992 Mar 31. PMID 1554698
    5. Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. Ichinose A, et al. Proc Natl Acad Sci U S A, 1991 Jan 1. PMID 1986355, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pseudogene PLGLA exerts anti-tumor effects on hepatocellular carcinoma through modulating miR-324-3p/GLYATL1 axis.
      Title: Pseudogene PLGLA exerts anti-tumor effects on hepatocellular carcinoma through modulating miR-324-3p/GLYATL1 axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • plasminogen pseudogene 2
    • plasminogen-like A
    • plasminogen-like A1
    • plasminogen-related protein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003506.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114755, DA634686, U67178
      Related
      ENST00000484422.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      106382114..106391395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      106842876..106852158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases