2HGF,1BHT,1GP9,1I8N


Conserved Protein Domain Family
PAN_AP_HGF
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cd01099: PAN_AP_HGF 
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Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.
Links
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Statistics
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PSSM-Id: 238532
Aligned: 49 rows
Threshold Bit Score: 42.4569
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative binding site
Evidence:
  • Comment:charged pocket believed to be general protein/carbohydrate binding site in diverse family members
  • Citation:PMID 9493272
  • Structure:1BHT_A, binds SO4 ion
    - View structure with Cn3D
  • Comment:heparin thought to bind at sulfate ion position
  • Citation:PMID 9817840
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           # #            #                                           
2HGF         9 IHEFKKsakTTLIKidpaLKIKTKkv--nTADQCANRCTrnk---glpFTCKAFVFDkarKQCLWFPFnsm-----ssGV 78   human
1BHT_A       5 IHEFKKsakTTLIKidpaLKIKTKkv--nTADQCANRCTrnk---glpFTCKAFVFDkarKQCLWFPFnsm-----ssGV 74   human
T29557     110 SESGCFt--STPGKvl-iGIVDQLvrdvaTVNDCQAQCSnsqt--kydITCKSAMYYekdKECILASQska-----diPD 179  Caenorhabditis e...
T21967     121 KAPYSFe--RYPQSil-iGHAMKVlt-vdGLSDCLSKCAlsqr--sydFLCKSAIYYyetGECIMNRDnkfi--ypklFK 192  Caenorhabditis e...
NP_495968  430 SNFVAFrdySVRIEa--vEEFNDLpkgydGMQLCIELCVls-----tkFTCRSSTFNpitGQCRLMTEdsm-----tsPD 497  Caenorhabditis e...
NP_503097  317 NLAGCFi--KTPNRil-hKFEESRig-gvTLETCMRQCAqsl----qnFYCASINYSfglKICILNGGnl------hlNG 382  Caenorhabditis e...
NP_509443  552 KSDDCYv--ELNDFvl-eGTAIAVet-avTPEECKCKCAeghk--lygEECASFLYYydsKTCLINKQnrfsnpekfnFV 625  Caenorhabditis e...
NP_509443  424 KRDGCFe--VIDDHlm-vSVAGGLeh-dmSIEECQCMCAnsktsrryeFQCRSATYYhaeRDCILNLEdrni--ksklFE 497  Caenorhabditis e...
NP_508240  123 CAQTQFi--RVDQSvl-vGYAVNMtl-tdSIESCAAQCVq-------eADCKSAMYFyedGECITNKEsamt--kpagFT 189  Caenorhabditis e...
NP_740858  105 QSPFQFd--LFEQRil-vGFAREVvp-aaNIQICMAACLnafd--tfgFECESAMFYpvdQECILNTEdrld--rpslFV 176  Caenorhabditis e...

Feature 1                      
2HGF        79 KKEFgh--efDLYENK 92   human
1BHT_A      75 KKEFgh--efDLYENK 88   human
T29557     180 LFIDdd--ksLYLENS 193  Caenorhabditis elegans
T21967     193 TNILdt--lvDYFENN 206  Caenorhabditis elegans
NP_495968  498 SFEYdefqkaLYFENG 513  Caenorhabditis elegans
NP_503097  383 GDTLvgsrefDYFENT 398  Caenorhabditis elegans
NP_509443  626 PSINqs---rSYFEWT 638  Caenorhabditis elegans
NP_509443  498 KQFTdv--nvTYIGLA 511  Caenorhabditis elegans
NP_508240  190 KEENdk---vIYFQNG 202  Caenorhabditis elegans
NP_740858  177 EESDdt---vIYMDNN 189  Caenorhabditis elegans

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