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Srpx sushi-repeat-containing protein [ Mus musculus (house mouse) ]

Gene ID: 51795, updated on 12-May-2024

Summary

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Official Symbol
Srpxprovided by MGI
Official Full Name
sushi-repeat-containing proteinprovided by MGI
Primary source
MGI:MGI:1858306
See related
Ensembl:ENSMUSG00000090084 AllianceGenome:MGI:1858306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
drs; DRS-1; DRS-2; drs-1; drs-2
Summary
Acts upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in autophagosome and endoplasmic reticulum. Is expressed in several structures, including otic capsule and skeleton. Orthologous to human SRPX (sushi repeat containing protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 23.2), bladder adult (RPKM 15.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 4.62 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (9904216..9983879, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (10037977..10117640, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 5 Neighboring gene H2A histone family member L3 Neighboring gene STARR-seq mESC enhancer starr_46716 Neighboring gene predicted gene 5754 Neighboring gene STARR-seq mESC enhancer starr_46717 Neighboring gene predicted gene, 33844 Neighboring gene retinitis pigmentosa GTPase regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy. Inoue Y, et al. Acta Neuropathol, 2017 Oct. PMID 28478503
  2. The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B. Tambe Y, et al. Mol Carcinog, 2016 Jan. PMID 25620379
  3. Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway. Tambe Y, et al. Cancer Lett, 2012 Jan 1. PMID 21983129
  4. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs. Tambe Y, et al. Carcinogenesis, 2007 Apr. PMID 17088259
  5. Isolation of a novel mouse variant of the drs tumor suppressor gene. Kawai T, et al. Cancer Lett, 2002 Sep 8. PMID 12049817

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40.
    Title: Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy.
  2. drs regulates glucose metabolism via LDH-B. Downregulating drs may contribute to the Warburg effect, which is closely associated with malignant progression of cancer cells.
    Title: The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
  3. Drs suppresses viral replication via mTOR-dependent pathway.
    Title: Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway.
  4. drs is involved in the maturation process of autophagy from autophagosomes to autolysosomes
    Title: The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.
  5. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs
    Title: Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.
  6. Isolation of a novel variant of the tumor suppressor gene (mDRS-2)
    Title: Isolation of a novel mouse variant of the drs tumor suppressor gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Potential readthrough

Included gene: Rpgr

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell proliferation involved in contact inhibition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phagolysosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phagolysosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sushi-repeat-containing protein SRPX
Names
sushi-repeat-containing protein, X-chromosome

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365087.1 → NP_001352016.1  sushi-repeat-containing protein SRPX isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BX005236
    Consensus CDS
    CCDS90696.1
    UniProtKB/TrEMBL
    A2BE45
    Related
    ENSMUSP00000111205.3, ENSMUST00000115543.3
    Conserved Domains (3) summary
    cd00033
    Location:178 → 233
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam02494
    Location:91 → 173
    HYR; HYR domain
    pfam13778
    Location:248 → 367
    DUF4174; Domain of unknown function (DUF4174)

  2. NM_016911.5 → NP_058607.1  sushi-repeat-containing protein SRPX isoform 1 precursor

    See identical proteins and their annotated locations for NP_058607.1

    Status: VALIDATED

    Source sequence(s)
    BX005236
    Consensus CDS
    CCDS30013.1
    UniProtKB/Swiss-Prot
    A2BE46, A2BE47, Q9R0M2, Q9R0M3
    UniProtKB/TrEMBL
    A2BE45
    Related
    ENSMUSP00000047926.4, ENSMUST00000044789.10
    Conserved Domains (3) summary
    cd00033
    Location:262 → 317
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam02494
    Location:175 → 257
    HYR; HYR domain
    pfam13778
    Location:332 → 449
    DUF4174; Domain of unknown function (DUF4174)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    9904216..9983879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0M3.1 GenPept UniProtKB/Swiss-Prot:Q9R0M3

Gene LinkOut

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