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Conserved domains on  [gi|1434520740|ref|NP_001352016|]
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sushi-repeat-containing protein SRPX isoform 2 precursor [Mus musculus]

Protein Classification

HYR and DUF4174 domain-containing protein( domain architecture ID 10034342)

protein containing domains HYR, CCP, and DUF4174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 248-367 4.89e-43

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


:

Pssm-ID: 463980  Cd Length: 120  Bit Score: 145.86  E-value: 4.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520740 248 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHVTVVELVGVFPTLIGRIRAKIMPPALALQLRLLLRIPL 327
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPDLIEELRKELGIPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1434520740 328 YSFSMVVVDKHGMDKERYVSLVTPMALFNLIDTFPLRKEE 367
Cdd:pfam13778  81 NYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 91-173 3.77e-33

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


:

Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 118.64  E-value: 3.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520740  91 VDLEPPRIKCPSVKERIAEPNKLTVRVSWESPEGRDTADGilTDVILKGLPPGSNFPEGDHKIEYTVYDRAENKGTCKFR 170
Cdd:pfam02494   1 VDTTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQ--AILVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFT 78


                  ...
gi 1434520740 171 VKV 173
Cdd:pfam02494  79 VTV 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 178-233 4.48e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 69.03  E-value: 4.48e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740 178 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSC 233
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 36-91 7.59e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 65.56  E-value: 7.59e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1434520740  36 CPTLTMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 91
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYsYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 248-367 4.89e-43

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 145.86  E-value: 4.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520740 248 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHVTVVELVGVFPTLIGRIRAKIMPPALALQLRLLLRIPL 327
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPDLIEELRKELGIPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1434520740 328 YSFSMVVVDKHGMDKERYVSLVTPMALFNLIDTFPLRKEE 367
Cdd:pfam13778  81 NYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 91-173 3.77e-33

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 118.64  E-value: 3.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520740  91 VDLEPPRIKCPSVKERIAEPNKLTVRVSWESPEGRDTADGilTDVILKGLPPGSNFPEGDHKIEYTVYDRAENKGTCKFR 170
Cdd:pfam02494   1 VDTTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQ--AILVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFT 78


                  ...
gi 1434520740 171 VKV 173
Cdd:pfam02494  79 VTV 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 178-233 4.48e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 69.03  E-value: 4.48e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740 178 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSC 233
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 36-91 7.59e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 65.56  E-value: 7.59e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1434520740  36 CPTLTMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 91
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYsYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 178-233 1.61e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 64.47  E-value: 1.61e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740  178 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSC 233
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 36-90 3.61e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 63.70  E-value: 3.61e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740   36 CPTLTMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 90
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYsYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
178-233 9.46e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.52  E-value: 9.46e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740 178 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSC 233
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
36-90 2.36e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.19  E-value: 2.36e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740  36 CPTLTMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 90
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYnYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 177-244 7.59e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 37.66  E-value: 7.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1434520740 177 RCgKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSCAAMNVNVGVRT 244
Cdd:PHA02831  140 RC-KYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKCVKDKVHNEIQP 206
 
Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 248-367 4.89e-43

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 145.86  E-value: 4.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520740 248 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHVTVVELVGVFPTLIGRIRAKIMPPALALQLRLLLRIPL 327
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPDLIEELRKELGIPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1434520740 328 YSFSMVVVDKHGMDKERYVSLVTPMALFNLIDTFPLRKEE 367
Cdd:pfam13778  81 NYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 91-173 3.77e-33

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 118.64  E-value: 3.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520740  91 VDLEPPRIKCPSVKERIAEPNKLTVRVSWESPEGRDTADGilTDVILKGLPPGSNFPEGDHKIEYTVYDRAENKGTCKFR 170
Cdd:pfam02494   1 VDTTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQ--AILVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFT 78


                  ...
gi 1434520740 171 VKV 173
Cdd:pfam02494  79 VTV 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 178-233 4.48e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 69.03  E-value: 4.48e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740 178 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSC 233
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 36-91 7.59e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 65.56  E-value: 7.59e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1434520740  36 CPTLTMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 91
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYsYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 178-233 1.61e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 64.47  E-value: 1.61e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740  178 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSC 233
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 36-90 3.61e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 63.70  E-value: 3.61e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740   36 CPTLTMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 90
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYsYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
178-233 9.46e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.52  E-value: 9.46e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740 178 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSC 233
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
36-90 2.36e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.19  E-value: 2.36e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1434520740  36 CPTLTMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 90
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYnYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 177-244 7.59e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 37.66  E-value: 7.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1434520740 177 RCgKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSCAAMNVNVGVRT 244
Cdd:PHA02831  140 RC-KYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKCVKDKVHNEIQP 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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