(Submitter supplied) Individuals expressing alpha-1-antitrypsin mutant Z protein accumulate misfolded, mutant protein in the liver and are at risk for liver diseases including cirrhosis and hepatocellular carcinoma. Transgenic PiZ mice, a model for this liver disease, display similar pathologies to humans, including inflammation, increases in proliferation, autophagy and apoptosis, accumulation of globules and develop fibrosis and hepatocellular carcinoma with age.
more...- Organism:
- Mus musculus
- Type:
- Expression profiling by array
- Platforms:
- GPL340 GPL339
- 8 Samples
Download data: CEL