PMEPA1 prostate transmembrane protein, androgen induced 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PMEPA1provided by HGNC
Official Full Name: prostate transmembrane protein, androgen induced 1provided by HGNC
Primary source: HGNC:HGNC:14107
See related: Ensembl:ENSG00000124225 MIM:606564; AllianceGenome:HGNC:14107
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STAG1; TMEPAI
Summary: This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Expression: Broad expression in prostate (RPKM 54.2), fat (RPKM 28.9) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (57648396..57711472, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (59426291..59489466, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (56223452..56286528, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
Title: METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
Exploring the role of PMEPA1 in gastric cancer.
Title: Exploring the role of PMEPA1 in gastric cancer.
PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer.
Title: PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer.
PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway.
Title: PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway.
PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer.
Title: PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer.
PMEPA1 Stimulates the Proliferation, Colony Formation of Pancreatic Cancer Cells via the MAPK Signaling Pathway.
Title: PMEPA1 Stimulates the Proliferation, Colony Formation of Pancreatic Cancer Cells via the MAPK Signaling Pathway.
PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer.
Title: PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer.
Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression.
Title: Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression.
Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer.
Title: Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer.
PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1.
Title: PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of prostate transmembrane protein, androgen induced 1 (PMEPA1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein prostate transmembrane protein, androgen induced 1 (PMEPA1) in cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G19813 (e-PCR)
- UniSTS:35591

A001Z16 (e-PCR)
- UniSTS:35592

RH47916 (e-PCR)
- UniSTS:57938

Z94435 (e-PCR)
- UniSTS:52639

RH75521 (e-PCR)
- UniSTS:87775

MARC_5563-5564:1031676346:1 (e-PCR)
- UniSTS:269539

STS-F01898 (e-PCR)
- UniSTS:26351

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables R-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables R-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables WW domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in androgen receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	TAS Traceable Author Statement more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: protein TMEPAI

Names: solid tumor-associated 1 protein; solid tumor-associated gene 1; transmembrane, prostate androgen induced RNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_031951.1 RefSeqGene

Range

6522..68141

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001255976.2 → NP_001242905.1 protein TMEPAI isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AF305616, AL121913, BQ008707, BU196912

UniProtKB/TrEMBL

Q66K30

Related

ENSP00000401506.1, ENST00000414037.5
NM_020182.5 → NP_064567.2 protein TMEPAI isoform a

See identical proteins and their annotated locations for NP_064567.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AF305616, AL121913, BM846677, BQ008707

Consensus CDS

CCDS13463.1

UniProtKB/Swiss-Prot

Q5TDR6, Q8NER4, Q969W9, Q96B72, Q9UJD3

UniProtKB/TrEMBL

Q66K30

Related

ENSP00000345826.3, ENST00000341744.8
NM_199169.3 → NP_954638.1 protein TMEPAI isoform b

See identical proteins and their annotated locations for NP_954638.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AF224278, AF305616, AK296199, BQ008707

Consensus CDS

CCDS13462.1

UniProtKB/TrEMBL

Q5JY37, Q66K30

Related

ENSP00000344014.4, ENST00000347215.8
NM_199170.3 → NP_954639.1 protein TMEPAI isoform c

See identical proteins and their annotated locations for NP_954639.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.

Source sequence(s)

AF305616, AK296199, AY128643, BQ008707

Consensus CDS

CCDS13464.1

UniProtKB/TrEMBL

Q66K30

Related

ENSP00000379161.3, ENST00000395816.7

Conserved Domains (1) summary

cl21455
Location:102 → 159

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_199171.3 → NP_954640.1 protein TMEPAI isoform c

See identical proteins and their annotated locations for NP_954640.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.

Source sequence(s)

AF305616, AL732104, BQ008707

Consensus CDS

CCDS13464.1

UniProtKB/TrEMBL

Q66K30

Related

ENSP00000265626.4, ENST00000265626.8

Conserved Domains (1) summary

cl21455
Location:102 → 159

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases