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    fgfr3 fibroblast growth factor receptor 3 [ Danio rerio (zebrafish) ]

    Gene ID: 58129, updated on 26-May-2024

    Summary

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    Official Symbol
    fgfr3provided by ZNC
    Official Full Name
    fibroblast growth factor receptor 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000816-1
    See related
    Ensembl:ENSDARG00000004782 AllianceGenome:ZFIN:ZDB-GENE-000816-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc27h01; sb:eu563; wu:fc27h01
    Summary
    Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cranium; gut; nervous system; neural rod; and neural tube. Human ortholog(s) of this gene implicated in several diseases, including Crouzon syndrome-acanthosis nigricans syndrome; LADD syndrome; SADDAN; bone development disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See fgfr3 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (13213566..13294982, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (13081091..13163841, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene uncharacterized LOC108191973 Neighboring gene uncharacterized LOC108191974

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling. Sun X, et al. Theranostics, 2020. PMID 32641982, Free PMC Article
    2. fgfr3 and regionalization of anterior neural tube in zebrafish. Sleptsova-Friedrich I, et al. Mech Dev, 2001 Apr. PMID 11287195
    3. The expression of fgfr3 in the zebrafish head. Ledwon JK, et al. Gene Expr Patterns, 2018 Sep. PMID 29630949
    4. Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in neurodevelopmental disorders. Aksoy I, et al. Hum Mol Genet, 2017 Jan 15. PMID 28365779
    5. Identification of a novel insertion mutation in FGFR3 that causes thanatophoric dysplasia type 1. Lindy AS, et al. Am J Med Genet A, 2016 Jun. PMID 27028100

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/beta-catenin signaling.
      Title: Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling.
    2. Zebrafish FGFR3 is a negative regulator of interferon (IFN) production in the innate immune response by suppressing the activity of TANK-binding kinase 1 (TBK1) in the process of virus infection.
      Title: Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression.
    3. Study revealed spatial and temporal distribution of fgfr3 transcript in chondrocytes of the head cartilages, osteoblasts involved in bone formation, ventricular zone of the brain, undifferentiated mesenchymal cells of the skin, and lens epithelium of the eye.
      Title: The expression of fgfr3 in the zebrafish head.
    4. Leg1 plays a unique role in protecting liver development under different stress conditions by serving as a secreted signaling molecule/modulator.
      Title: Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fibroblast growth factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of macromolecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor receptor 3
    NP_571681.2
    XP_009305459.1
    XP_009305463.1
    XP_017214284.1
    XP_021336328.1
    XP_021336329.1
    XP_021336330.1
    XP_021336331.1
    XP_021336332.1
    XP_021336333.1
    XP_021336334.1
    XP_021336335.1
    XP_021336336.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131606.2 → NP_571681.2  fibroblast growth factor receptor 3 precursor

      Status: VALIDATED

      Source sequence(s)
      CR556722, CR559942, CU694230, LO018146
      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M1PBP7, F1QPA0
      Related
      ENSDARP00000011898.9, ENSDART00000013534.9
      Conserved Domains (7) summary
      cd04974
      Location:280 → 369
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:173 → 257
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:466 → 799
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:183 → 257
      IG; Immunoglobulin
      smart00410
      Location:272 → 368
      IG_like; Immunoglobulin like
      pfam07714
      Location:479 → 754
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      13213566..13294982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480656.1 → XP_021336331.1  fibroblast growth factor receptor 3 isoform X6

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M9QJU0
      Conserved Domains (4) summary
      cd05857
      Location:172 → 256
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:467 → 800
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type
      cd04974
      Location:279 → 366
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

    2. XM_009307184.3 → XP_009305459.1  fibroblast growth factor receptor 3 isoform X5

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M3B7V7
      Conserved Domains (7) summary
      cd04974
      Location:280 → 367
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:173 → 257
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:467 → 800
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:183 → 257
      IG; Immunoglobulin
      smart00410
      Location:272 → 367
      IG_like; Immunoglobulin like
      pfam07714
      Location:480 → 755
      Pkinase_Tyr; Protein tyrosine kinase

    3. XM_021480654.1 → XP_021336329.1  fibroblast growth factor receptor 3 isoform X2

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M9QFJ7
      Conserved Domains (4) summary
      cd05857
      Location:173 → 257
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:468 → 801
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type
      cd04974
      Location:280 → 367
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

    4. XM_021480658.1 → XP_021336333.1  fibroblast growth factor receptor 3 isoform X9

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M9Q9X2
      Conserved Domains (4) summary
      cd05857
      Location:168 → 252
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:275 → 364
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:463 → 796
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type

    5. XM_021480657.1 → XP_021336332.1  fibroblast growth factor receptor 3 isoform X7

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M9PY42
      Conserved Domains (4) summary
      cd05857
      Location:169 → 253
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:276 → 365
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:464 → 797
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type

    6. XM_021480655.1 → XP_021336330.1  fibroblast growth factor receptor 3 isoform X4

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M9QNI1
      Conserved Domains (4) summary
      cd05857
      Location:172 → 256
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:279 → 368
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:467 → 800
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type

    7. XM_021480661.1 → XP_021336336.1  fibroblast growth factor receptor 3 isoform X12

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M9QJU4
      Conserved Domains (3) summary
      cd05857
      Location:83 → 167
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:190 → 279
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:378 → 711
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

    8. XM_021480660.1 → XP_021336335.1  fibroblast growth factor receptor 3 isoform X11

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M9QNI4
      Conserved Domains (3) summary
      cd05857
      Location:84 → 168
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:191 → 280
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:379 → 712
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

    9. XM_021480659.1 → XP_021336334.1  fibroblast growth factor receptor 3 isoform X10

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M9QFK2
      Conserved Domains (4) summary
      cd05857
      Location:168 → 252
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:275 → 364
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:462 → 795
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type

    10. XM_009307188.3 → XP_009305463.1  fibroblast growth factor receptor 3 isoform X8

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M3B533
      Conserved Domains (7) summary
      cd04974
      Location:276 → 365
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:169 → 253
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:463 → 796
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:179 → 253
      IG; Immunoglobulin
      smart00410
      Location:268 → 364
      IG_like; Immunoglobulin like
      pfam07714
      Location:476 → 751
      Pkinase_Tyr; Protein tyrosine kinase

    11. XM_017358795.2 → XP_017214284.1  fibroblast growth factor receptor 3 isoform X3

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M6Z1R4

    12. XM_021480653.1 → XP_021336328.1  fibroblast growth factor receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9I8X3
      UniProtKB/TrEMBL
      A0A8M9Q9W6
      Conserved Domains (4) summary
      cd05857
      Location:173 → 257
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:280 → 369
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:468 → 801
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:67 → 121
      IGc2; Immunoglobulin C-2 Type

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395307.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      270317..294997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I8X3.1 GenPept UniProtKB/Swiss-Prot:Q9I8X3

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