cd04974: Ig3_FGFR (this model, PSSM-Id:319280 is obsolete and has been replaced by 409363)
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
Ig3_FGFR: third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR). Fibroblast growth factors (FGFs) participate in morphogenesis, development, angiogenesis, and wound healing. These FGF-stimulated processes are mediated by four FGFR tyrosine kinases (FGRF1-4). FGFRs are comprised of an extracellular portion consisting of three Ig-like domains, a transmembrane helix, and a cytoplasmic portion having protein tyrosine kinase activity. The highly conserved Ig-like domains 2 and 3, and the linker region between D2 and D3 define a general binding site for FGFs.
Feature 1:polypeptide ligand binding site [polypeptide binding site]
Evidence:
Structure:1EV2_A; Fibroblast Growth Factor 2 (FGF2) complexed with the Ig-like domains D2 and D3 of FGF receptor 2 (FGFR2), contacts based on 3.5 A distance. - View structure with Cn3D
Jiyao W et al.(2023). "The conserved domain database in 2023.",