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    TENM2 teneurin transmembrane protein 2 [ Homo sapiens (human) ]

    Gene ID: 57451, updated on 6-Jun-2024

    Summary

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    Official Symbol
    TENM2provided by HGNC
    Official Full Name
    teneurin transmembrane protein 2provided by HGNC
    Primary source
    HGNC:HGNC:29943
    See related
    Ensembl:ENSG00000145934 MIM:610119; AllianceGenome:HGNC:29943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ODZ2; TEN2; TNM2; ten-2; TEN-M2
    Summary
    Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Located in cell-cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart (RPKM 7.7), brain (RPKM 2.7) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TENM2 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (166979029..168264157)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (167513669..168798988)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (166406034..167691162)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377706 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:166309500-166310699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:166405091-166405592 Neighboring gene long intergenic non-protein coding RNA 1947 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:166405593-166406092 Neighboring gene uncharacterized LOC101927908 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:166721659-166722858 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:166724659-166725364 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:166730399-166730914 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:166732502-166733336 Neighboring gene uncharacterized LOC124901126 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167000055-167000680 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167000681-167001306 Neighboring gene uncharacterized LOC124901127 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:167125182-167125888 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:167126594-167127299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167286415-167286982 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:167312930-167313167 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:167342965-167344164 Neighboring gene uncharacterized LOC105377709 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:167364582-167365781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:167372775-167373276 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:167420767-167421268 Neighboring gene uncharacterized LOC124900211 Neighboring gene Sharpr-MPRA regulatory region 1255 Neighboring gene NANOG hESC enhancer GRCh37_chr5:167474734-167475491 Neighboring gene NANOG hESC enhancer GRCh37_chr5:167537301-167537860 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:167551431-167552630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16593 Neighboring gene uncharacterized LOC124901128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23587 Neighboring gene microRNA 12125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16594 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16595 Neighboring gene TENM2 antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:167741294-167741817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167754608-167755524 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167755525-167756441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16597 Neighboring gene uncharacterized LOC124901129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167792124-167792657 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:167836336-167837535 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83602 Neighboring gene WW and C2 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23590 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83610 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83640 Neighboring gene arginyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones. Vysokov NV, et al. Elife, 2018 Nov 20. PMID 30457553, Free PMC Article
    2. Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells. Tews D, et al. Mol Cell Endocrinol, 2017 Mar 5. PMID 28088466
    3. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Silva JP, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21724987, Free PMC Article
    4. Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3. Vinatzer U, et al. Clin Cancer Res, 2008 Oct 15. PMID 18927281
    5. The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. Bagutti C, et al. J Cell Sci, 2003 Jul 15. PMID 12783990

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings reveal a novel mechanism of axonal pathfinding, whereby latrophilin-1 and Lasso mediate both short-range interaction that supports synaptogenesis, and long-range signaling that induces axonal attraction.
      Title: Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.
    2. TENM2 knockdown induces both UCP1 mRNA and protein expression upon adipogenic differentiation without affecting mitochondrial mass.
      Title: Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Gene rearrangements of ODZ2 is associated with mucosa-associated lymphoid tissue lymphoma.
      Title: Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.
    5. intracellular domain of teneurin-2 has a nuclear function and role in repressing zic-1-mediated transcription
      Title: The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog
    Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia.
    EBI GWAS Catalog
    Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
    EBI GWAS Catalog
    Genome-wide association study of periodontal pathogen colonization.
    EBI GWAS Catalog
    Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686A1568

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    teneurin-2
    Names
    neurestin alpha
    odd Oz/ten-m homolog 2
    odz, odd Oz/ten-m homolog 2
    protein Odd Oz/ten-m homolog 2
    tenascin-M2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080428.3 → NP_001073897.2  teneurin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and has multiple difference in the central coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB032953, AC093304, AK056053, AL137500, BF950845, BQ774782, BX648178, CR936703
      Consensus CDS
      CCDS83040.1
      UniProtKB/TrEMBL
      A0A8Q3SIB5, F8VNQ3
      Related
      ENSP00000427874.1, ENST00000520394.5
      Conserved Domains (12) summary
      COG3209
      Location:1450 → 2243
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:439 → 468
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1046 → 1095
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2152 → 2228
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:502 → 650
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1443 → 1481
      RHS_repeat; RHS Repeat
      pfam06484
      Location:16 → 183
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:348 → 370
      EGF_2; EGF-like domain
      pfam13715
      Location:700 → 784
      CarbopepD_reg_2; CarboxypepD_reg-like domain
      pfam15636
      Location:2453 → 2528
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1008 → 1331
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:523 → 564
      DSL; Delta serrate ligand

    2. NM_001122679.2 → NP_001116151.1  teneurin-2 isoform 1

      See identical proteins and their annotated locations for NP_001116151.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC008464, AC008601, AC008607, AC008637, AC008642, AC008705, AC011369, AC026689, AC093304
      UniProtKB/TrEMBL
      A0A8Q3SIB5
      Conserved Domains (10) summary
      COG3209
      Location:1946 → 2432
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:798 → 831
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1231 → 1270
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2382 → 2458
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1231 → 1561
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:1673 → 1709
      RHS_repeat; RHS Repeat
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2681 → 2758
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      pfam19232
      Location:575 → 734
      DUF5885; Family of unknown function (DUF5885)
      cl19567
      Location:755 → 796
      DSL; Delta serrate ligand

    3. NM_001368145.1 → NP_001355074.1  teneurin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008464, AC008634, AC008637, AC008705, AC011369, AC026689, AC093304
      UniProtKB/TrEMBL
      A0A8Q3SIB5

    4. NM_001368146.1 → NP_001355075.1  teneurin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008464, AC008634, AC008637, AC008705, AC011369, AC026689, AC093304
      Consensus CDS
      CCDS93819.1
      UniProtKB/TrEMBL
      A0A8Q3SI97, A0A8Q3SIB5
      Related
      ENSP00000512239.1, ENST00000695886.1

    5. NM_001395460.1 → NP_001382389.1  teneurin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008464, AC008601, AC008607, AC008637, AC008642, AC008705, AC011369, AC026689, AC026729, AC093304
      Consensus CDS
      CCDS93818.1
      UniProtKB/Swiss-Prot
      Q9NT68, Q9ULU2
      UniProtKB/TrEMBL
      A0A8Q3SIB5
      Related
      ENSP00000429430.1, ENST00000518659.6
      Conserved Domains (8) summary
      COG3209
      Location:1955 → 2441
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1240 → 1279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2391 → 2467
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1240 → 1570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:1682 → 1718
      RHS_repeat; RHS Repeat
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2690 → 2767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570 → 885
      exchanger_TraA; outer membrane exchange protein TraA

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      166979029..168264157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417418.1 → XP_047273374.1  teneurin-2 isoform X3

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    2. XM_017009661.2 → XP_016865150.1  teneurin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    3. XM_005265950.3 → XP_005266007.1  teneurin-2 isoform X2

      See identical proteins and their annotated locations for XP_005266007.1

      UniProtKB/TrEMBL
      A0A8Q3SIB5
      Conserved Domains (10) summary
      COG3209
      Location:1946 → 2432
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:798 → 831
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1231 → 1270
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2382 → 2458
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1231 → 1561
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:1673 → 1709
      RHS_repeat; RHS Repeat
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2681 → 2758
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      pfam19232
      Location:575 → 734
      DUF5885; Family of unknown function (DUF5885)
      cl19567
      Location:755 → 796
      DSL; Delta serrate ligand

    4. XM_011534604.3 → XP_011532906.1  teneurin-2 isoform X5

      UniProtKB/TrEMBL
      A0A8Q3SIB5
      Conserved Domains (11) summary
      COG3209
      Location:1618 → 2411
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:671 → 700
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1169 → 1208
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2320 → 2396
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:640 → 811
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1611 → 1649
      RHS_repeat; RHS Repeat
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:576 → 602
      EGF_2; EGF-like domain
      pfam13715
      Location:861 → 945
      CarbopepD_reg_2; CarboxypepD_reg-like domain
      pfam15636
      Location:2621 → 2696
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1169 → 1499
      NHL; NHL repeat unit of beta-propeller proteins

    5. XM_047417420.1 → XP_047273376.1  teneurin-2 isoform X8

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    6. XM_017009662.2 → XP_016865151.1  teneurin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    7. XM_047417419.1 → XP_047273375.1  teneurin-2 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    8. XM_017009665.2 → XP_016865154.1  teneurin-2 isoform X16

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    9. XM_047417427.1 → XP_047273383.1  teneurin-2 isoform X17

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    10. XM_017009669.2 → XP_016865158.1  teneurin-2 isoform X20

      UniProtKB/TrEMBL
      A0A8Q3SIA3, A0A8Q3SIB5

    11. XM_017009663.3 → XP_016865152.1  teneurin-2 isoform X6

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    12. XM_047417421.1 → XP_047273377.1  teneurin-2 isoform X9

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    13. XM_047417422.1 → XP_047273378.1  teneurin-2 isoform X10

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    14. XM_047417423.1 → XP_047273379.1  teneurin-2 isoform X11

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    15. XM_017009664.2 → XP_016865153.1  teneurin-2 isoform X12

      UniProtKB/TrEMBL
      A0A8Q3SIB5, G3V106
      Related
      ENSP00000428964.1, ENST00000519204.5
      Conserved Domains (12) summary
      COG3209
      Location:1568 → 2361
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:550 → 579
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1119 → 1158
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2270 → 2346
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:613 → 761
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1561 → 1599
      RHS_repeat; RHS Repeat
      pfam06484
      Location:44 → 253
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:459 → 481
      EGF_2; EGF-like domain
      pfam13715
      Location:811 → 895
      CarbopepD_reg_2; CarboxypepD_reg-like domain
      pfam15636
      Location:2571 → 2646
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1119 → 1449
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:634 → 675
      DSL; Delta serrate ligand

    16. XM_047417424.1 → XP_047273380.1  teneurin-2 isoform X13

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    17. XM_047417425.1 → XP_047273381.1  teneurin-2 isoform X14

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    18. XM_047417426.1 → XP_047273382.1  teneurin-2 isoform X15

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    19. XM_047417432.1 → XP_047273388.1  teneurin-2 isoform X21

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    20. XM_047417430.1 → XP_047273386.1  teneurin-2 isoform X19

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    21. XM_017009668.2 → XP_016865157.1  teneurin-2 isoform X20

      UniProtKB/TrEMBL
      A0A8Q3SIA3, A0A8Q3SIB5
      Related
      ENSP00000512289.1, ENST00000695961.1

    22. XM_047417431.1 → XP_047273387.1  teneurin-2 isoform X19

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    23. XM_047417428.1 → XP_047273384.1  teneurin-2 isoform X18

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    24. XM_047417429.1 → XP_047273385.1  teneurin-2 isoform X19

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    25. XM_047417433.1 → XP_047273389.1  teneurin-2 isoform X22

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    26. XM_005265952.3 → XP_005266009.1  teneurin-2 isoform X23

      UniProtKB/TrEMBL
      A0A8Q3SIB5
      Related
      ENSP00000512290.1, ENST00000695962.1
      Conserved Domains (11) summary
      COG3209
      Location:1293 → 2086
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:275 → 304
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:844 → 883
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:1995 → 2071
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:338 → 486
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1286 → 1324
      RHS_repeat; RHS Repeat
      pfam07974
      Location:184 → 206
      EGF_2; EGF-like domain
      pfam13715
      Location:536 → 620
      CarbopepD_reg_2; CarboxypepD_reg-like domain
      pfam15636
      Location:2296 → 2371
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:844 → 1174
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:359 → 400
      DSL; Delta serrate ligand

    27. XM_047417434.1 → XP_047273390.1  teneurin-2 isoform X24

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    28. XM_047417435.1 → XP_047273391.1  teneurin-2 isoform X25

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      167513669..168798988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352965.1 → XP_054208940.1  teneurin-2 isoform X3

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    2. XM_054352963.1 → XP_054208938.1  teneurin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    3. XM_054352964.1 → XP_054208939.1  teneurin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    4. XM_054352971.1 → XP_054208946.1  teneurin-2 isoform X5

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    5. XM_054352973.1 → XP_054208948.1  teneurin-2 isoform X8

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    6. XM_054352970.1 → XP_054208945.1  teneurin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    7. XM_054352972.1 → XP_054208947.1  teneurin-2 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    8. XM_054352978.1 → XP_054208953.1  teneurin-2 isoform X16

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    9. XM_054352979.1 → XP_054208954.1  teneurin-2 isoform X17

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    10. XM_054352985.1 → XP_054208960.1  teneurin-2 isoform X20

      UniProtKB/TrEMBL
      A0A8Q3SIA3, A0A8Q3SIB5

    11. XM_054352966.1 → XP_054208941.1  teneurin-2 isoform X26

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    12. XM_054352967.1 → XP_054208942.1  teneurin-2 isoform X27

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    13. XM_054352968.1 → XP_054208943.1  teneurin-2 isoform X28

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    14. XM_054352969.1 → XP_054208944.1  teneurin-2 isoform X29

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    15. XM_054352974.1 → XP_054208949.1  teneurin-2 isoform X12

      UniProtKB/TrEMBL
      A0A8Q3SIB5, G3V106

    16. XM_054352975.1 → XP_054208950.1  teneurin-2 isoform X13

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    17. XM_054352976.1 → XP_054208951.1  teneurin-2 isoform X14

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    18. XM_054352977.1 → XP_054208952.1  teneurin-2 isoform X15

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    19. XM_054352986.1 → XP_054208961.1  teneurin-2 isoform X21

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    20. XM_054352982.1 → XP_054208957.1  teneurin-2 isoform X19

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    21. XM_054352983.1 → XP_054208958.1  teneurin-2 isoform X19

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    22. XM_054352984.1 → XP_054208959.1  teneurin-2 isoform X20

      UniProtKB/TrEMBL
      A0A8Q3SIA3, A0A8Q3SIB5

    23. XM_054352980.1 → XP_054208955.1  teneurin-2 isoform X18

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    24. XM_054352981.1 → XP_054208956.1  teneurin-2 isoform X19

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    25. XM_054352987.1 → XP_054208962.1  teneurin-2 isoform X22

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    26. XM_054352988.1 → XP_054208963.1  teneurin-2 isoform X23

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    27. XM_054352989.1 → XP_054208964.1  teneurin-2 isoform X24

      UniProtKB/TrEMBL
      A0A8Q3SIB5

    28. XM_054352990.1 → XP_054208965.1  teneurin-2 isoform X25

      UniProtKB/TrEMBL
      A0A8Q3SIB5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NT68.3 GenPept UniProtKB/Swiss-Prot:Q9NT68

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