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    VWF von Willebrand factor [ Felis catus (domestic cat) ]

    Gene ID: 493760, updated on 5-Mar-2024

    Summary

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    Official Symbol
    VWF
    Official Full Name
    von Willebrand factor
    Primary source
    VGNC:VGNC:97686
    See related
    EnsemblRapid:ENSFCTG00005025212
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    See VWF in Genome Data Viewer
    Location:
    chromosome: B4
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (41211845..41349251, complement)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (41119862..41257079, complement)

    Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene anoctamin 2 Neighboring gene uncharacterized LOC109501435 Neighboring gene 60S ribosomal protein L34-like Neighboring gene uncharacterized LOC123386820 Neighboring gene uncharacterized LOC123386515 Neighboring gene uncharacterized LOC123386514

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence on mammalian phylogeny from sequences of exon 28 of the von Willebrand factor gene. Porter CA, et al. Mol Phylogenet Evol, 1996 Feb. PMID 8673300
    2. Highly congruent molecular support for a diverse superordinal clade of endemic African mammals. Stanhope MJ, et al. Mol Phylogenet Evol, 1998 Jun. PMID 9667998
    3. Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. Dang LT, et al. J Biol Chem, 2011 Jul 22. PMID 21592973, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    von Willebrand factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001246279.1 → NP_001233208.1  von Willebrand factor precursor

      See identical proteins and their annotated locations for NP_001233208.1

      Status: PROVISIONAL

      Source sequence(s)
      BK007986
      UniProtKB/TrEMBL
      A0A061DD19, A0A337S7R6
      Related
      ENSFCTP00005050979.1, ENSFCTT00005071894.1
      Conserved Domains (12) summary
      smart00041
      Location:2727 → 2808
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:2431 → 2494
      VWC; von Willebrand factor (vWF) type C domain
      smart00215
      Location:350 → 394
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:377 → 540
      VWD; von Willebrand factor (vWF) type D domain
      smart00327
      Location:1277 → 1449
      VWA; von Willebrand factor (vWF) type A domain
      smart00832
      Location:1053 → 1127
      C8; This domain contains 8 conserved cysteine residues
      pfam00092
      Location:1498 → 1643
      VWA; von Willebrand factor type A domain
      pfam00094
      Location:35 → 179
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:295 → 348
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2135 → 2199
      C8; C8 domain
      pfam16164
      Location:1198 → 1276
      VWA_N2; VWA N-terminal
      cl17735
      Location:2582 → 2644
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      41211845..41349251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045060755.1 → XP_044916690.1  von Willebrand factor isoform X1

      UniProtKB/TrEMBL
      A0A337S7R6
      Conserved Domains (8) summary
      smart00041
      Location:2727 → 2808
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:2431 → 2494
      VWC; von Willebrand factor (vWF) type C domain
      smart00215
      Location:350 → 394
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:377 → 540
      VWD; von Willebrand factor (vWF) type D domain
      smart00327
      Location:1691 → 1857
      VWA; von Willebrand factor (vWF) type A domain
      smart00832
      Location:1053 → 1127
      C8; This domain contains 8 conserved cysteine residues
      cd01450
      Location:1497 → 1645
      vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl17735
      Location:2582 → 2644
      VWC; von Willebrand factor type C domain
    Nucleotide Protein
    Heading Accession and Version

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