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    Adam28 ADAM metallopeptidase domain 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290344, updated on 2-May-2024

    Summary

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    Official Symbol
    Adam28provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 28provided by RGD
    Primary source
    RGD:727820
    See related
    Ensembl:ENSRNOG00000014518 AllianceGenome:RGD:727820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable endopeptidase activity and metallopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in mitochondrion. Predicted to be active in plasma membrane. Orthologous to human ADAM28 (ADAM metallopeptidase domain 28). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 9.8), Uterus (RPKM 7.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adam28 in Genome Data Viewer
    Location:
    15p11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (50184286..50250605, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (43774463..43840726, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (50356745..50425911, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosome biogenesis regulator 1 homolog, pseudogene 13 Neighboring gene septin 2, pseudogene 1 Neighboring gene ribosomal protein L7a, pseudogene 3 Neighboring gene stanniocalcin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-574-3p inhibits the malignant behavior of liver cancer cells by targeting ADAM28. Zha Z, et al. Oncol Lett, 2020 Sep. PMID 32782619, Free PMC Article
    2. Selective Inhibition of ADAM28 Suppresses Lung Carcinoma Cell Growth and Metastasis. Mochizuki S, et al. Mol Cancer Ther, 2018 Nov. PMID 30190423
    3. Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor. Lv YL, et al. Med Oncol, 2012 Dec. PMID 22354764
    4. ADAM23 is a cell-surface glycoprotein expressed by central nervous system neurons. Goldsmith AP, et al. J Neurosci Res, 2004 Dec 1. PMID 15505805
    5. Catalytic activity of ADAM28. Howard L, et al. FEBS Lett, 2001 Jun 1. PMID 11389903

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 28
    Names
    a disintegrin and metallopeptidase domain 28
    a disintegrin and metalloprotease domain 28
    a disintegrin and metalloproteinase domain 28
    NP_001381600.1
    XP_017455117.1
    XP_038949072.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394671.1 → NP_001381600.1  disintegrin and metalloproteinase domain-containing protein 28 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6A4L8
      Conserved Domains (3) summary
      smart00050
      Location:419 → 493
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:496 → 623
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:206 → 400
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

    RNA

    1. NR_172143.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      50184286..50250605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093144.2 → XP_038949072.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4L8
      Related
      ENSRNOP00000085690.1
      Conserved Domains (4) summary
      smart00050
      Location:419 → 493
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:496 → 623
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:206 → 400
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01562
      Location:31 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_017599628.3 → XP_017455117.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4L8, A6HTG5
      Related
      ENSRNOP00000076864.1
      Conserved Domains (5) summary
      smart00050
      Location:419 → 493
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:496 → 623
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:206 → 400
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:206 → 402
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42 → 156
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein Strain
    Heading Accession and Version

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