4DD8,3G5C


Conserved Protein Domain Family
Reprolysin

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pfam01421: Reprolysin (this model, PSSM-Id:279729 is obsolete and has been replaced by 426256)
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Reprolysin (M12B) family zinc metalloprotease
The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.
Statistics
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PSSM-Id: 279729
Aligned: 19 rows
Threshold Bit Score: 241.024
Created: 7-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4DD8_D         5 RYVELYVVVDNAEFQMLG-SEAAVRHRVLEVVNHVDKLYQK-LNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQAR 82  human
Q3TTE0       185 RFIMMDIIVDKKLFDYMGsDTEVVLQKVIQIIGFVNTMLSK-LKLTVLINSIEIWSKENRIRLSKAVDDLLVQFSIWKHE 263 house mouse
Q60718       184 HYLEIHIVVEKQMFEHIGaDTAIVTQKIFQLIGLANAIFAP-FNLTVILSSLEFWMDENKILTTGDANKLLYRFLKWKQS 262 house mouse
Q99965       178 KYIEMHVIVEKQLYNHMGsDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHTFLRWKTS 256 human
3G5C_B         7 KYIELMIVNDHLMFKKHRlSVVHTNTYAKSVVNMADLIYKDqLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRD 86  human
O75078       239 KYVELIVINDHQLFEQMRqSVVLTSNFAKSVVNLADVIYKEqLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRRE 318 human
O15204       218 KYIDLYLVLDNAFYKNYNeNLTLIRSFVFDVMNLLNVIYNT-IDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSS 296 human
Q63180       199 KFIELFVVADEFVYRRNSkPQNKLRKRIWGMVNFVNMIYKA-LNIRVTLTGMEIWSAGDEIEIVSNLESTLLHFSTWQET 277 Norway rat
Q28475       199 KYIELFIVADDTVYRRNShPHNKLRNRIWGMVNFVNMIYKT-LNIHVTLVGIEIWTHEDKIELHSNIETTLLRFSSWQER 277 crab-eating mac...
XP_002805363 187 RTLKIQIIMDKAMYDYMGsAVAVAVEKVFQIFGLINTMFSQ-LNITVMLSSLEIWSDQNKISTSGHADEILQRFLLWKQK 265 Rhesus monkey
4DD8_D        83 QRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSH-SSGAVNQDH-S-KNPVGVACTMAHEMGHNLGMDHDENv---QGC 156 human
Q3TTE0       264 YRS----QHVAYLLAFEEHPA-STGALYPGNLCKLeYNAAVALYP-KgLSLESFSVIVLQLLSIGMGLTYDTE-----NC 332 house mouse
Q60718       263 YLV-LRPHDMAFLLVYRNTTD-YVGATYQGKMCDKnYAGGVALHP-KaVTLESLAIILVQLLSLSMGLAYDDVn---K-C 335 house mouse
Q99965       257 YLV-LRPHDVAFLLVYREKSN-YVGATFQGKMCDAnYAGGVVLHP-RtISLESLAVILAQLLSLSMGITYDDI----NKC 329 human
3G5C_B        87 FIKEKS--DAVHLFSGSQFESSRSGAAYIGGICSLlKGGGVNEFG----KTDLMAVTLAQSLAHNIGIISDKRklasGEC 160 human
O75078       319 GLPEPS--DATHLFSGRTFQSTSSGAAYVGGICSLsHGGGVNEYG----NMGAMAVTLAQTLGQNLGMMWNKHrssaGDC 392 human
O15204       297 NLGKKI-HDHAQLLSGISFNNRRVGLAASNSLCSP-SSVAVIEAK-K-KNNVALVGVMSHELGHVLGMPDVPFn---T-- 367 human
Q63180       278 VLKKRKDFDHVILLSGKWLYTSMQGIAYPGGICQTlRSCSVVKDL-L-PDVNIIGNRMAHQLGHSLGMRHDDF-----PC 350 Norway rat
Q28475       278 ILKTRKDFDHVVLLSGKWIYTHVQGISYPAGMCLPyYSTSIIKDL-L-PDTNIIANRMAHQLGHNLGMQHDEF-----PC 350 crab-eating mac...
XP_002805363 266 LLFQR-SHDMTYLLIYRNHS-TYVGATYHGMACDPkFATGIALYPkK-ITVEAFSVVMAQLLGINLGLTYDDI----YNC 338 Rhesus monkey
4DD8_D       157 RCQerfEAGRCIMAGSIGSSFPR-M-FSDCSQAYLESFLERPQSVCLANAP 205 human
Q3TTE0       333 HC----TGEVCLMTPKAIYSGGVkD-FSTCTLDDFKYLSTRQDLRCLQDLP 378 house mouse
Q60718       336 QCG----VPVCVMNPEAPHSSGVrA-FSNCSMEDFSKFITSQSSHCLQNQP 381 house mouse
Q99965       330 QC----SGAVCIMNPEAIHFSGVkI-FSNCSFEDFAHFISKQKSQCLHNQP 375 human
3G5C_B       161 KCEd--TWSGCIMGD-TGYYLPK-K-FTQCNIEEYHDFLNSGGGACLFNKP 206 human
O75078       393 KCPd--IWLGCIMED-TGFYLPR-K-FSRCSIDEYNQFLQEGGGSCLFNKP 438 human
O15204       368 KC----PSGSCVMNQYLSSKFPK-D-FSTSCRAHFERYLLSQKPKCLLQAP 412 human
Q63180       351 TC----PLGKCVMG--AGSIPAI-K-FSKCSQTQYQQFLKNQKPACILNNP 393 Norway rat
Q28475       351 TC----PSGKCVM-DSDGSIPAL-K-FSKCSQNQYHQYLKDYKPTCMLNIP 394 crab-eating macaque
XP_002805363 339 YC----PGPTCIMNPDAIRSHGM-KfFSSCSMDEFKQIVLQPELKCFQDKt 384 Rhesus monkey
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