CIT citron rho-interacting serine/threonine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: CITprovided by HGNC
Official Full Name: citron rho-interacting serine/threonine kinaseprovided by HGNC
Primary source: HGNC:HGNC:1985
See related: Ensembl:ENSG00000122966 MIM:605629; AllianceGenome:HGNC:1985
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CITK; CRIK; STK21; MCPH17
Summary: This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression: Broad expression in brain (RPKM 9.1), testis (RPKM 3.2) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.23

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (119685791..119877320, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (119673075..119864647, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (120123596..120315124, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase.
Title: Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase.
Novel circRNA_0071196/miRNA19b3p/CIT axis is associated with proliferation and migration of bladder cancer.
Title: Novel circRNA_0071196/miRNA‑19b‑3p/CIT axis is associated with proliferation and migration of bladder cancer.
Down-regulation of CIT can inhibit the growth of human bladder cancer cells.
Title: Down-regulation of CIT can inhibit the growth of human bladder cancer cells.
gene expression profile data set showed that MM patients with high CIT gene expression had significantly worse overall survival compared with MM patients with low CIT gene expression. CIT silencing in MM cell lines induced cytokinesis failure and resulted in decreased MM cell proliferation in vitro and in vivo.
Title: Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma.
CIT-K overexpression is associated with breast cancer.
Title: Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism.
CITK deletion decreased tumor growth and increased overall survival in these mice, with no apparent side effects. These results suggest that CITK can be a useful molecular target for medulloblastoma treatment.
Title: Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence.
in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.
Title: ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
Control of abscission requires Eph kinase activity, and Src and citron kinase (CitK) are downstream effectors in the Eph-induced signal transduction cascade
Title: Eph-mediated tyrosine phosphorylation of citron kinase controls abscission.
The striking phenotypic overlap between CIT-mutated individuals and the knockout mice and rats that are specifically deficient in the kinase domain supports the proposed causal link between CIT mutation and primary microcephaly in humans.
Title: Mutations in CIT, encoding citron rho-interacting serine/threonine kinase, cause severe primary microcephaly in humans.
Splice site variant in CIT, identified in this study, is predicted to abolish splice donor site. cDNA sequence of an affected individual showed retention of an intron next to the splice donor site. The study, presented here, revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family.
Title: CIT, a gene involved in neurogenic cytokinesis, is mutated in human primary microcephaly.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Microcephaly 17, primary, autosomal recessive MedGen: C4310723 OMIM: 617090 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 replication is enhanced by CIT expression, which is dependent on NEDD4L expression as shown through siRNA knockdown of NEDD4L	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 Gag polyubiquitination is enhanced by CIT (citron kinase)	PubMed
	gag	HIV-1 Gag interacts with the zinc finger, RhoA-binding, and leucine zipper domains of CIT (citron kinase) in HEK293T cells	PubMed
	gag	Ectopic expression of citron kinase leads to the formation of cytoplasmic structures containing citron kinase and HIV-1 Gag proteins	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH48058 (e-PCR)
- UniSTS:52233

G29083 (e-PCR)
- UniSTS:47377

D12S395 (e-PCR), detects polymorphism
- UniSTS:1044

D12S321 (e-PCR), detects polymorphism
- UniSTS:31006

RH45006 (e-PCR)
- UniSTS:48686

D12S321 (e-PCR), detects polymorphism
- UniSTS:68659

CIT_4577 (e-PCR)
- UniSTS:464470

G17631 (e-PCR)
- UniSTS:5763

D12S1666 (e-PCR), detects polymorphism
- UniSTS:5781

RH15678 (e-PCR)
- UniSTS:20886

G44706 (e-PCR)
- UniSTS:95181

G15656 (e-PCR)
- UniSTS:40911

D12S1993 (e-PCR)
- UniSTS:46297

G49179 (e-PCR)
- UniSTS:96233

PMC137543P1 (e-PCR)
- UniSTS:270835

PMC137543P2 (e-PCR)
- UniSTS:270836

PMC137543P3 (e-PCR)
- UniSTS:270837

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables scaffold protein binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in generation of neurons	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed

General protein information

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Preferred Names: citron Rho-interacting kinase

Names: citron (rho-interacting, serine/threonine kinase 21); serine/threonine kinase 21; serine/threonine-protein kinase 21

NP_001193928.1

EC 2.7.11.1

NP_009105.1

EC 2.7.11.1

XP_006719269.1

EC 2.7.11.1

XP_011536085.1

EC 2.7.11.1

XP_011536086.1

EC 2.7.11.1

XP_011536087.1

EC 2.7.11.1

XP_011536089.1

EC 2.7.11.1

XP_011536090.1

EC 2.7.11.1

XP_011536091.1

EC 2.7.11.1

XP_011536092.1

EC 2.7.11.1

XP_011536093.1

EC 2.7.11.1

XP_016874224.1

EC 2.7.11.1

XP_016874225.1

EC 2.7.11.1

XP_016874226.1

EC 2.7.11.1

XP_047284090.1

EC 2.7.11.1

XP_054226823.1

EC 2.7.11.1

XP_054226824.1

EC 2.7.11.1

XP_054226825.1

EC 2.7.11.1

XP_054226826.1

EC 2.7.11.1

XP_054226827.1

EC 2.7.11.1

XP_054226828.1

EC 2.7.11.1

XP_054226829.1

EC 2.7.11.1

XP_054226830.1

EC 2.7.11.1

XP_054226831.1

EC 2.7.11.1

XP_054226832.1

EC 2.7.11.1

XP_054226833.1

EC 2.7.11.1

XP_054226834.1

EC 2.7.11.1

XP_054226835.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029792.2 RefSeqGene

Range

5000..196529

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001206999.2 → NP_001193928.1 citron Rho-interacting kinase isoform 1

See identical proteins and their annotated locations for NP_001193928.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC004813, AY257469, AY681966

Consensus CDS

CCDS55891.1

UniProtKB/Swiss-Prot

O14578

Related

ENSP00000376306.2, ENST00000392521.7

Conserved Domains (6) summary

smart00036
Location:1635 → 1931

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 360

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1196
Location:474 → 1335

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1405 → 1453

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:95 → 422

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1486 → 1605

PH; PH domain
NM_007174.3 → NP_009105.1 citron Rho-interacting kinase isoform 2

See identical proteins and their annotated locations for NP_009105.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC004813, AY257469, AY681966

Consensus CDS

CCDS9192.1

UniProtKB/Swiss-Prot

O14578, Q2M5E1, Q6XUH8, Q86UQ9, Q9UPZ7

UniProtKB/TrEMBL

H7BYJ3

Related

ENSP00000261833.7, ENST00000261833.11

Conserved Domains (7) summary

smart00036
Location:1593 → 1889

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 360

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1340
Location:558 → 844

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

COG4942
Location:1083 → 1365

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1363 → 1411

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:95 → 422

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1444 → 1563

PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

119685791..119877320 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011537788.2 → XP_011536090.1 citron Rho-interacting kinase isoform X10

UniProtKB/TrEMBL

H7BYJ3

Conserved Domains (7) summary

smart00036
Location:1578 → 1874

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 360

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1340
Location:558 → 844

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

COG4942
Location:1083 → 1350

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1348 → 1396

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:95 → 422

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1429 → 1548

PH; PH domain
XM_011537787.2 → XP_011536089.1 citron Rho-interacting kinase isoform X9

See identical proteins and their annotated locations for XP_011536089.1

UniProtKB/TrEMBL

H7BYJ3

Conserved Domains (7) summary

smart00036
Location:1578 → 1874

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 360

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1340
Location:558 → 844

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

COG4942
Location:1083 → 1350

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1348 → 1396

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:95 → 422

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1429 → 1548

PH; PH domain
XM_047428134.1 → XP_047284090.1 citron Rho-interacting kinase isoform X8
XM_017018737.2 → XP_016874226.1 citron Rho-interacting kinase isoform X7
XM_006719206.3 → XP_006719269.1 citron Rho-interacting kinase isoform X6

Conserved Domains (6) summary

smart00036
Location:1620 → 1916

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 360

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1196
Location:474 → 1320

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1390 → 1438

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:95 → 422

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1471 → 1590

PH; PH domain
XM_017018736.2 → XP_016874225.1 citron Rho-interacting kinase isoform X5
XM_011537785.2 → XP_011536087.1 citron Rho-interacting kinase isoform X3

Conserved Domains (6) summary

smart00036
Location:1635 → 1931

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 360

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1196
Location:474 → 1320

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1390 → 1438

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:95 → 422

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1471 → 1590

PH; PH domain
XM_017018735.2 → XP_016874224.1 citron Rho-interacting kinase isoform X4
XM_011537784.2 → XP_011536086.1 citron Rho-interacting kinase isoform X2

Conserved Domains (5) summary

smart00109
Location:1405 → 1453

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00036
Location:1650 → 1946

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1486 → 1605

PH; Pleckstrin homology domain

COG1196
Location:474 → 1335

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:95 → 422

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_011537783.2 → XP_011536085.1 citron Rho-interacting kinase isoform X1

Conserved Domains (6) summary

smart00036
Location:1650 → 1946

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 360

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1196
Location:474 → 1335

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1405 → 1453

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:95 → 422

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1486 → 1605

PH; PH domain
XM_011537790.2 → XP_011536092.1 citron Rho-interacting kinase isoform X11

See identical proteins and their annotated locations for XP_011536092.1

UniProtKB/TrEMBL

A0A7I2V692

Conserved Domains (9) summary

smart00036
Location:1204 → 1500

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1040 → 1159

PH; Pleckstrin homology domain

COG4942
Location:679 → 961

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:2 → 641

PRK03918; chromosome segregation protein; Provisional

cd00029
Location:959 → 1007

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00169
Location:1040 → 1159

PH; PH domain

pfam00836
Location:231 → 319

Stathmin; Stathmin family

pfam09311
Location:462 → 743

Rab5-bind; Rabaptin-like protein

cl00788
Location:188 → 253

MttA_Hcf106; mttA/Hcf106 family
XM_011537789.2 → XP_011536091.1 citron Rho-interacting kinase isoform X11

See identical proteins and their annotated locations for XP_011536091.1

UniProtKB/TrEMBL

A0A7I2V692

Related

ENSP00000504849.1, ENST00000678652.1

Conserved Domains (9) summary

smart00036
Location:1204 → 1500

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1040 → 1159

PH; Pleckstrin homology domain

COG4942
Location:679 → 961

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:2 → 641

PRK03918; chromosome segregation protein; Provisional

cd00029
Location:959 → 1007

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00169
Location:1040 → 1159

PH; PH domain

pfam00836
Location:231 → 319

Stathmin; Stathmin family

pfam09311
Location:462 → 743

Rab5-bind; Rabaptin-like protein

cl00788
Location:188 → 253

MttA_Hcf106; mttA/Hcf106 family
XM_011537791.3 → XP_011536093.1 citron Rho-interacting kinase isoform X12

UniProtKB/TrEMBL

A0A7I2V692

Conserved Domains (9) summary

smart00036
Location:1184 → 1480

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1020 → 1139

PH; Pleckstrin homology domain

COG4942
Location:659 → 941

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:12 → 578

PRK03918; chromosome segregation protein; Provisional

cd00029
Location:939 → 987

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam00169
Location:1020 → 1139

PH; PH domain

pfam00836
Location:211 → 299

Stathmin; Stathmin family

pfam09311
Location:442 → 723

Rab5-bind; Rabaptin-like protein

cl00788
Location:168 → 233

MttA_Hcf106; mttA/Hcf106 family